COMPARATIVE STUDY ON THE EFFICACY OF MOMETASONE AND FLUTICASONE NASAL SPRAYS FOR TREATMENT OF ALLERGIC RHINITIS


Mahshid Sadat Mirmoezzi, Mohammad Shurideh Yazdi, Omid Gholami

Abstract


Objective: Allergic rhinitis is the most prevalent of allergic diseases in the world. Nasal corticosteroids are the most applicable drugs for the treatment of allergic rhinitis. In this study, we compared the efficacy of fluticasone propionate (FP) and mometasone furoate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.

Methods: For this study, 75 allergic rhinitis patients based on skin prick test and inclusion criteria were randomly assigned to two groups: FP and MF groups. FP group received 200 µg dose of FP nasal spray (1 spray/nostril) daily and the MF group received 100 mg dose of MF nasal spray (1 spray/nostril) daily for 8 w. The effects of the two agents were compared based on TNSS questionnaire in 0, 4 and 8 w after the beginning of the treatment.

Results: Results showed that patients in both groups exhibited significant improvement in their TNSS (P Value<0.001). A detailed TNSS analysis showed MF to be more effective for relieving all symptoms than FP. The most difference is in decreasing postnasal discharge (PND) symptom. However, the difference for relieving all symptoms is not significant (P value>0.05).

Conclusion: In conclusion, FP and MF are significantly effective in relieving of allergic rhinitis symptoms. Even though, the difference between the two is not significant for 8 w therapy. 


Keywords


Fluticasone Propionate, Mometaseone Furoate, Allergic Rhinitis, Total Nasal Symptom Score (TNSS) questionnaire

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About this article

Title

COMPARATIVE STUDY ON THE EFFICACY OF MOMETASONE AND FLUTICASONE NASAL SPRAYS FOR TREATMENT OF ALLERGIC RHINITIS

Keywords

Fluticasone Propionate, Mometaseone Furoate, Allergic Rhinitis, Total Nasal Symptom Score (TNSS) questionnaire

DOI

10.22159/ijpps.2017v9i3.15958

Date

03-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 3, 2017 Page: 211-214

Online ISSN

0975-1491

Statistics

57 Views | 68 Downloads

Authors & Affiliations

Mahshid Sadat Mirmoezzi
Medical Student at the Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Iran, Islamic Republic of

Mohammad Shurideh Yazdi
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

Omid Gholami
Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

 

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