A ROLE FOR PHALERIA MACROCARPA (SCHEFF) BOERL. EXTRACTS IN THE MANAGEMENT OF WOMEN’S PATHOLOGICAL CONDITIONS: A RESEARCH REVIEW


Raymond Rubianto Tjandrawinata, Hanna Christabel Rouli

Abstract


Phaleria macrocarpa (Scheff) Boerl is a medicinal plant that originates from West Papua, Indonesia. The fruit of this plant is known to contain numerous different compounds that produce different bioactivities. Many of these bioactivities are related to women pathological conditions. The purpose of this review is to evaluate the effect of P. macrocarpa fruit extract in the management of these conditions. Different studies have proven that P. macrocarpa extract helps regulate hormone imbalance in women with problems relating to their menstruation cycle, especially during premenstrual syndrome. It helps alleviate symptoms of primary dysmenorrhea and endometriosis through its bioactivity as anti-inflammation, apoptosis inducer, anti-angiogenic and anti-oxidant agent. P. macrocarpa fruit extract also showed selective anti-proliferative, anti-inflammatory, and anti-angiogenic activity on breast and cervical cancer cells. It regulates cancer cell progression through numerous different pathways, making it highly favourable to be developed as a cancer treatment, whether as a single treatment or as an adjunct therapy. In conclusion, P. macrocarpa extract has great potential to be developed into treatments for women’s pathological conditions. However, further study, both preclinical and clinical studies are needed to ascertain its use in women to be effective and safe.


Keywords


Phaleria macrocarpa, Premenstrual syndrome, Endometriosis, Breast cancer, Cervical cancer, Hormone imbalance

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About this article

Title

A ROLE FOR PHALERIA MACROCARPA (SCHEFF) BOERL. EXTRACTS IN THE MANAGEMENT OF WOMEN’S PATHOLOGICAL CONDITIONS: A RESEARCH REVIEW

Keywords

Phaleria macrocarpa, Premenstrual syndrome, Endometriosis, Breast cancer, Cervical cancer, Hormone imbalance

DOI

10.22159/ijpps.2017v9i3.16001

Date

03-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 3, 2017 Page: 7-12

Online ISSN

0975-1491

Statistics

169 Views | 115 Downloads

Authors & Affiliations

Raymond Rubianto Tjandrawinata
Dexa Laboratories of Biomolecular Sciences, Industri Selatan V Block PP no. 7, Kawasan Industri Jababeka II, Cikarang 17550, Indonesia
Indonesia

Hanna Christabel Rouli
Dexa Laboratories of Biomolecular Sciences, Industri Selatan V Block PP no. 7, Kawasan Industri Jababeka II, Cikarang 17550, Indonesia
Indonesia


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