• Jyoti Nehra Department of Pharmacology, Pt. B. D. Sharma PGIMS, Rohtak
  • Jyoti Kaushal Department of Pharmacology, Pt. B. D. Sharma PGIMS, Rohtak
  • Savita Rani Singhal Department of Obstetrics & Gynaecology, Pt. B. D. Sharma PGIMS, Rohtak
  • Veena Singh Ghalaut Department of Biochemistry, Pt. B. D. Sharma PGIMS, Rohtak



PCOS, BMI, WHR, Myo-inositol, Metformin, Anthropometric


Objective: The objective of the study was to evaluate and compare the effect of insulin sensitizers i.e. metformin and myoinositol on anthropometric parameters in patients of the Polycystic ovarian syndrome (PCOS).

Methods: A prospective, open-labeled, randomized, comparative, clinical study was conducted on 60 patients. The patients were randomly divided into two groups of 30 each to receive either of the following two treatments: group A: Tablet myoinositol 1g twice daily. group B: Tablet metformin 500 mg thrice daily for 24 w. Anthropometric parameters were assessed by measuring body weight, Body mass index (BMI), waist circumference, hip circumference, waist-hip ratio (WHR) at baseline and subsequently at the end of 12 w and 24 w.

Results: In both the groups, there was a statistically significant improvement in over a period of 24 w. In group A, the values for weight at baseline, 12 w and 24 w expressed in mean±SEM are 63.96±.90, 62.33±.88 and 61.20±.85 while in group B the values were 63.58±1.88, 62.26±1.74 and 60.86±1.65. In group A, the values for BMI at baseline, 12 w and 24 w were 26.45±.41, 25.78±.42 and 25.31±.40 while in group B the values were 26.09±.76, 25.53±.71 and 24.96±.68 respectively. In group A, WHR values were 0.79±.007, 0.78±.007 and 0.78±.007 while in group B 0.79±.010, 0.79±0.108, 0.79±.011 at baseline, 12 w and 24 w respectively. However, on comparing both the groups at 12 and 24 w, no statistically significant difference was observed in all the parameters.

Conclusion: There was a definite improvement in anthropometric parameters with both metformin and myoinositol but on comparing these drugs, no significant difference was observed. Thus, myoinositol can also be used as an alternative to metformin for the treatment of PCOS.


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How to Cite

Nehra, J., J. Kaushal, S. R. Singhal, and V. S. Ghalaut. “COMPARISION OF MYO-INOSITOL VERSUS METFORMIN ON ANTHROPOMETRIC PARAMETERS IN POLYCYSTIC OVARIAN SYNDROME IN WOMEN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 4, Apr. 2017, pp. 144-8, doi:10.22159/ijpps.2017v9i4.16359.



Original Article(s)