HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT


E. Sovia, W. Ratwita, D. Wijayanti, D. R. Novianty

Abstract


Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.

Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.

Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups.

Conclusion: In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.


Keywords


Annona muricata, Hypoglycemic, Hypolipidemic, Phytochemical, Alloxan

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About this article

Title

HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ANNONA MURICATA L. LEAF ETHANOL EXTRACT

Keywords

Annona muricata, Hypoglycemic, Hypolipidemic, Phytochemical, Alloxan

DOI

10.22159/ijpps.2017v9i3.16402

Date

03-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 3, 2017 Page: 170-174

Online ISSN

0975-1491

Statistics

85 Views | 56 Downloads

Authors & Affiliations

E. Sovia
Pharmacology Laboratory, Faculty of Medicine, Universitas Jenderal Achmad Yani, Jl Terusan Jenderal Sudirman,Cimahi, West Java, Indonesia
Indonesia

W. Ratwita
Pharmacology Laboratory, Faculty of Medicine, Universitas Jenderal Achmad Yani, Jl Terusan Jenderal Sudirman,Cimahi, West Java, Indonesia
Indonesia

D. Wijayanti
Indonesia

D. R. Novianty
Indonesia


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