Bebee Pathare, Vrushali Tambe, Vandana Patil


Determination of dissociation constant for a drug capable of ionization within a pH range of 1 to 10 is important since solubility and consequently absorption, can be altered by orders of magnitude with changing pH. The dissociation constant [pKa] value, are essential for understanding many fundamental reactions in chemistry. These values reveal the deprotonation state of a molecule in a particular solvent. There is great interest in using experimental methods to calculate the pKa values for many different types of molecules. In this review the most valuable methods for determining accurate pKa values are presented. There are many diverse strategies for determining dissociation constant, so the main aim of the review is to discuss the available analytical methods.



Dissociation constant, pH, potentiometric measurement, capillary electrophoresis, Deprotonation.

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Dissociation constant, pH, potentiometric measurement, capillary electrophoresis, Deprotonation.



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International Journal of Pharmacy and Pharmaceutical Sciences
Vol 6, Issue 8, 2014 Page: 26-34

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Authors & Affiliations

Bebee Pathare
Department of pharmaceutics, P. E. S’s, Modern College of Pharmacy [for ladies], Borhadewadi, Moshi, Pune 412105 India

Vrushali Tambe
Department of pharmaceutics, P. E. S’s, Modern College of Pharmacy [for ladies], Borhadewadi, Moshi, Pune 412105 India

Vandana Patil
Department of pharmaceutics, P. E. S’s, Modern College of Pharmacy [for ladies], Borhadewadi, Moshi, Pune 412105 India

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