PREPARATION AND CHARACTERISATION OF IBUPROFEN LOADED POLYMERIC NANOPARTICLES BY SOLVENT EVAPORATION TECHNIQUE

Authors

  • VUTPALA SREELOLA M. Pharmacy Student, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad
  • Abbaraju Krishna Sailaja Associate Professor, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad

Keywords:

Nanoparticles, Ethyl cellulose, Eudragit, Solvent evaporation, Drug release

Abstract

Objective: In the present study Ibuprofen loaded nanoparticles were prepared by solvent evaporation technique. Comparative study was done among the formulations to know the best stabilizer and the polymer for ibuprofen loaded nanoparticles.

Methods: Four formulations F1, F2, F3 and F4 were prepared by solvent evaporation technique by changing the polymers and the stabilizers. The polymers used were Ethyl cellulose and Eudragit S-100 and the stabilizers were tween 80 and 0.4% PVA.The drug and the polymers was dissolved in solvent mixture of DCM and methanol in 1:1 ratio and added to the aqueous stabilizers. Comparative study was done to know the better formulation for EC with 0.4% PVA and tween 80, and also for Eudragit S-100 with Tween 80 and 0.4%PVA.Further Comparative study was performed between the best formulation of EC (F2) and Eudragit S-100 (F3).The effect of stabilizer and the polymer on nanoparticle size, stability, loading capacity, encapsulation efficiency and In vitro drug release was studied.

Results: Ibuprofen nanoparticles.F1,F2,F3 and F4 were prepared by using EC with tween 80 and 0.4% PVA and Eudragit with the same stabilzers. The particle size and stability of the formulations was determined by Horiba SZ 100 series particle size analyzer. Encapsulation efficiency and loading capacity were determined by ELTEK NP 400 Ultracentrifuge. The drug content was found to be 87%,88.72%,81.05% and 80.6%,encapsulation efficiency was found to be 56.25%,88.36%,71.7% and 55.9 %,loading capacity was found to be 28.8%,39.2%,33% and 28.4% respectively for F1,F2,F3 and F4. The average particle size was found to be 320.9 nm for F2 and 694.8 nm for F3.The zeta potential was found to be optimum for both the formulations.

Conclusions: On comparison F2 was considered to be the best formulation for the preparation of Ibuprofen loaded nanoparticles because of the smaller particle size and greater stability, greater loading capacity and encapsulation efficiency. The drug release was sustained till 8 hrs for nanoparticles in F2.

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Published

31-08-2014

How to Cite

SREELOLA, V., and A. K. Sailaja. “PREPARATION AND CHARACTERISATION OF IBUPROFEN LOADED POLYMERIC NANOPARTICLES BY SOLVENT EVAPORATION TECHNIQUE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 416-21, https://innovareacademics.in/journals/index.php/ijpps/article/view/1721.

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