ANTI-HYPERGLYCEMIC EFFECT OF TERMINALIA CATAPPA FRUIT EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS


Tapan Behl, Anita Kotwani

Abstract


Objective: To explore the anti-hyperglycemic effect of fruit extract of Terminalia catappa (Indian almond), a potential medicine from plant origin in a diabetic rat model.

Methods: Streptozotocin-induced chronic diabetic rat model was utilized in the study. Three doses of test drug, hydro-alcoholic fruit extract of Terminalia catappa in 20 mg/kg, 30 mg/kg and 40 mg/kg and a standard anti-diabetic drug, glibenclamide (10 mg/kg) was used. The study had a total of nine groups with eight animals in each group. Drugs were given orally every day for 12 w. Blood glucose, body weight and urine volume were measured weekly, glycosylated hemoglobin (HbA1c) was estimated at 12th week in all groups. Data for all parameters were analyzed using one-way ANOVA repeated measures followed by Mann-Whitney test.

Results: Hydro-alcoholic fruit extract of T. catappa significantly decreased blood glucose, urine volume and increased body weight in a dose-dependent manner in diabetic rats. At 12th week, blood glucose level in control, diabetic control, glibenclamide, T. catappa (40 mg/kg) group was 96.25±2.05 mg/dl, 599.75±0.25 mg/dl, 248.25±11.45 mg/dl, 115.00±3.78 mg/dl respectively. Effect of T. catappa in 30 mg/kg and 40 mg/kg dose was significantly more than glibenclamide. At 12th week, HbA1c level in control, diabetic control, glibenclamide, T. catappa (40 mg/kg) was 2.94±0.33 mmol/l, 4.94±0.49 mmol/l, 3.61±0.28 mmol/l, 3.21±0.27 mmol/l. Treatment with T. catappa 30 mg/kg, 40 mg/kg and glibenclamide brought back the level of HbA1c to normal levels. The addition of glibenclamide to T. catappa (40 mg/kg) did not produce any additional effect on blood glucose and HbA1c levels compared to the effect of T. catappa (40 mg/kg) in diabetic rats.

Conclusion: Terminalia catappa fruit extract exhibited a significant anti-hyperglycemic effect in diabetic rats and has a great potential to be used in diabetes.


Keywords


Anti-diabetic activity, Blood sugar, Experimental diabetes, Indian badam, Glycosylated hemoglobin

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About this article

Title

ANTI-HYPERGLYCEMIC EFFECT OF TERMINALIA CATAPPA FRUIT EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Keywords

Anti-diabetic activity, Blood sugar, Experimental diabetes, Indian badam, Glycosylated hemoglobin

DOI

10.22159/ijpps.2017v9i4.17593

Date

03-03-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 4, 2017 Page: 212-217

Online ISSN

0975-1491

Statistics

126 Views | 37 Downloads

Authors & Affiliations

Tapan Behl
Department of Pharmacology V. P.Chest Institute University of Delhi Delhi 110007
India

Anita Kotwani
Department of Pharmacology V. P. Chest Institute University of Delhi
India


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