ANTICANCER ACTIVITIES OF THIOSEMICARBAZIDES/THIOSEMICARBAZONES: A REVIEW


Shefali Arora, Shilpi Agarwal, Shailey Singhal

Abstract


There have been tremendous development in the chemotherapy of cancer and researches are still developing new and more effective drugs to combat this disease. Thiosemicarbazides and thiosemicarbazone possess a wide range of biological applications. This key biological role is often related with their capability to inhibit the enzyme ribonucleotide reductase, similar to what is observed with potent anticancer drugs such as triapine and methisazone. Recent studies have revealed that thiosemicarbazones can inhibit topoisomerase II enzyme. This review discusses current advances of an emerging ‘new wave’ of thiosemicarbazide/thiosemicarbazone and their metal complexes as potent anticancer agents, mode of action and toxicity caused by them.

 


Keywords


Anticancer, Antineoplastic, Antitumor, Thiosemicarbazide, Topoisomerase.

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About this article

Title

ANTICANCER ACTIVITIES OF THIOSEMICARBAZIDES/THIOSEMICARBAZONES: A REVIEW

Keywords

Anticancer, Antineoplastic, Antitumor, Thiosemicarbazide, Topoisomerase.

Date

01-10-2014

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 6, Issue 9, 2014 Page: 34-41

Online ISSN

0975-1491

Statistics

2258 Views | 342 Downloads

Authors & Affiliations

Shefali Arora
Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007 (Uttarakhand), India
India

Shilpi Agarwal
Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007 (Uttarakhand), India
India

Shailey Singhal
University of Petroleum & Energy Studies, Dehradun (Uttarakhand), India
India


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