FORMULATION AND EVALUATION OF TIME-RELEASE COMPRESSION COATED TABLET CONTAINING ACEBROPHYLLINE FOR CHRONOTHERAPY OF ASTHMA.
Objective: The aim of present research was to develop compression coated tablet for pulsatile drug delivery of Acebrophylline used for chronotherapy of asthma. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of asthma.
Methods: The compression coated tablets containing Acebrophylline in the inner core were formulated by direct compression method with an outer coating of different amounts of HPMC K4M.
Results: The release profile of press coated tablet exhibited a lag time depending upon the amount of HPMC K4M in compression coating, followed by burst release. Optimization was done using 32 factorial design considering two independent factors at three levels. Data was evaluated statistically by Stat Ease Design Expert 7.0.0 software. The optimized batch F6 gave a lag time of 6 hr and drug release of 94% in which the concentration of HPMC K4M is 40% and the concentration of SSG is 2.5 %.
Conclusion: The chronodelivery of Acebrophylline was achieved by formulating the tablet by compression coating technique.
2. Gandhi BR, Mundada AS, Gandhi PP, Chronopharmaceutics: as a clinically relevant drug delivery system. Drug Del 2011;18:1-18.
3. Bi-Botti C Youan. Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery. J of Controlled Release 2004;98:337â€“ 53.
4. Asim SM, Nikhil B, Kazi MK, Arijit G, Sugata C, Mamata B. Drug delivery system based on chronobiology-A review. J of Controlled Release 2010;147:314â€“25.
5. Ashwini R, Bushetti SS, Archana G. Formulation and Evaluation of compression coated tablets based on modified okra mucilage. Int J Pharm Pharm Sci 2012;4:660-7.
6. Alessandra M, Lucia Z, Maria DDC, Giulia L, Andrea G. Oral pulsatile delivery: rationale and chronopharmaceutical formulations. Int J of Pharm 2010;398:1â€“8.
7. Dharmarajsinh C, Shrenik S. Formulation and Evaluation of Pulsatile Drug Delivery System of Aceclofenac for treatment of rheumatoid arthritis. Int J Pharmacy and Pharm Sci 2012;4:507-12.
8. Bose S, Bogner RH. Solventless pharmaceutical coating processes: a review. Pharm Dev Technol 2007;12:115â€“31.
9. Picker KM, Influence of tableting on the enzymatic activity of different amylases using various excipients. Eur J Pharm Biopharm 2002;53:181â€“5.
10. Maggi L, Conte U, Giunchedi P, Colombo P. Press-coated tablets for the sequential pulsed administration of two different drugs. Int J Pharm 1993;99:173â€“9.
11. Waterman KC, Fergione MB. Press-coating of immediate release powders onto coated controlled release tablets with adhesives. J Control Release 2003;89:387â€“95.
12. Halsas M, Pentinen P, Veski H, JÃ¼rjenson H, Marvola M, Time controlled release pseudoephedrine tablets: bioavailability and in vitro/in vivo correlations. Pharmazie 2003;56:718â€“23.
13. Conte U, Maggi L, Torre ML, Giunchedi P, Manna AL. Press-coated tablets for time-programmed release of drugs. Biomaterials 1993;14:1017â€“23.
14. Sirkia T, Salonen H, Veski P, JÃ¼rjenson H, Marvola M. Biopharmaceutical evaluation of new prolonged-release press-coated ibuprofen tablets containing sodium alginate to adjust drug release. Int J Pharm 1994;107:179â€“87.
15. Wu B, Shun N, Wei X. Characterization of 5-fluorouracil release from hydroxypropyl-methylcellulose compression-coated tablets. Pharm Dev Technol 2007;12:203â€“10.
16. Fukui E, Uemura K, Kobayashi M. Studies on applicability of press-coated tablets using hydroxyl propyl cellulose (HPC) in the outer shell for timed-release preparations. J Control Release 2000;68:215â€“23.
17. Sawada T, Kondo H, Nakashima H, Sako K, Hayashi M. Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy. Int J Pharm 2004;280:103â€“11.
18. Lin SY, Lin KH, Li MJ. Micronized ethylcellulose used for designing a directly compressed time-controlled disintegration tablet. J Control Release 2001;70:321â€“8.
19. Lin SY, Lin KH, Li MJ. Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets. J Pharm Sci 2002;91:2040â€“6.
20. Gonzalez-Rodriguez ML, Maestrelli, Mura P, Rabasco AM. In vitro release of sodium diclofenac from a central core matrix tablet aimed for colonic drug delivery. Eur J Pharm Sci 2003;20:125â€“31.
21. Peerapattana J, Otsuka K, Otsuka M. Time-controlled pulse-drug release from dry-coated wax matrix tablets for colon drug delivery. Biomed Mater Eng 2004;14:293â€“301.
22. Streubel A, Siepmann J, Peppas NA, Bodmeier R. Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design. J Control Release 2000;69:455â€“68.
23. Lopes CM, Lobo JM, Pinto JF, Costa PC. Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen. AAPS Pharm Sci Tech 2007;8:E76.