HESPERIDIN HYDROGEL FORMULATION USING PECTIN-CHITOSAN POLYMER COMBINATION


Andhi Fahrurroji, Dea Thendriani, Hafrizal Riza

Abstract


Objective: Hesperidin is flavonoid glycosides that proven to have therapeutic activity to any desease, one of them is colon disease; but, its low solubility (< 100 mg/L) makes small absosption inside the body so it needs delivery system that could deliver hesperidin to the therapy target. The objective of this research is to get optimum formula from hydrogel with polimer pectin-chitosan combination that can control in vitro hesperidin release.

Method: Optimum hydrogel formula determination using Design Expert 7.0.0 with factorial method design, resulted in formula plans with pectin-chitosan consentration comparison of (P3% : C1%), (P3% : C2%), (P5% : C1%), (P5% : C2%) respectively.

Result: Optimum formula with pectin : chitosan concentration comparison (5% : 1%) has entrapment efficiency about 96.658%; k(/hour) swelling index at pH 5.0, 6.8, and 7.4, about 34.917, 15.766, and 8.146 respectively; drug release at pH 5.0, 6.8, and a medium contained 2% mouse’s caecum  about 0.461, 20.116, and 52.955% respectively; and the mucoadhesive strength about 0.184 N/cm2.

Conclusion: The combination of pectin-chitosan polymer in hydrogel muchoadhesive matrix can control hesperidin in vitro release with the drug release value at the highest concentration of pectin in medium contained 2% mouse’s saecum that could release drug about 56%. Hesperidin hydrogel release mechanism follows Higuchi kinetic.


Keywords


Hesperidin, Hydorgel, Chitosan, Colon, Pectin

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About this article

Title

HESPERIDIN HYDROGEL FORMULATION USING PECTIN-CHITOSAN POLYMER COMBINATION

Keywords

Hesperidin, Hydorgel, Chitosan, Colon, Pectin

DOI

10.22159/ijpps.2017v9i12.19816

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 12, 2017 Page: 98-104

Online ISSN

0975-1491

Statistics

20 Views | 4 Downloads

Authors & Affiliations

Andhi Fahrurroji
Departement of Pharmaceutical Technology, Pharmacy Subject, Faculty of Medicine, Tanjungpura University
Indonesia

Dea Thendriani
Undergradute Program of Pharmacy Department Tanjungpura University
Indonesia

Hafrizal Riza
Departement of Chemical Pharmacy, Pharmacy Subject, Faculty of Medicine, Tanjungpura University
Indonesia


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