SIMULTANEOUS DETERMINATION OF FLURBIPROFEN AND PANTOPRAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETER

  • Varaprasad Adepu Department of Pharmaceutical Analysis, JNTUK, Kakinada, AP533003
  • K. E. V Nagoji Department of Pharmaceutical Analysis, Srivenkateswara college of Pharmacy, Srikakulam, AP 532410
  • V. Girijasastry Department of Pharmaceutical Chemistry, Andhra University, Visakhapatnam, AP 530003

Abstract

Objective: A simple, rapid, precise and accurate spectrophotometric method has been developed for determination of Flurbiprofen and Pantoprazole by simultaneous equation method in combined dosage form

Methods: The 6.8 pH phosphate buffer was selected as solvent for developing spectral characteristics of both drugs. The method was validated for recovery studies.

Results: The λmax of Flubiprofen was found to be 230 nm and Pantoprazole was found to be 270 nm. The method obeyed Beer’s law in the concentration range of 10-100 μg/ml for Flurbiprofen and 10-100 μg/ml for Pantoprazole. The percentage recovery of Flubiprofen was found to be 99.16 and Pantoprazole was found to be 99.46.

Conclusion: The proposed method was validated and can be used for analysis of combined tablet formulation containing Flurbiprofen and Pantoprazole.


 

Keywords: Flurbiprofen, Pantoprazole, Simultaneous equation method, and Validation.

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How to Cite
Adepu, V., K. E. V. Nagoji, and V. Girijasastry. “SIMULTANEOUS DETERMINATION OF FLURBIPROFEN AND PANTOPRAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETER”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 9, 1, pp. 31-33, https://innovareacademics.in/journals/index.php/ijpps/article/view/2042.
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