SIMULTANEOUS DETERMINATION OF FLURBIPROFEN AND PANTOPRAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETER
Objective: A simple, rapid, precise and accurate spectrophotometric method has been developed for determination of Flurbiprofen and Pantoprazole by simultaneous equation method in combined dosage form
Methods: The 6.8 pH phosphate buffer was selected as solvent for developing spectral characteristics of both drugs. The method was validated for recovery studies.
Results: The Î»max of Flubiprofen was found to be 230 nm and Pantoprazole was found to be 270 nm. The method obeyed Beerâ€™s law in the concentration range of 10-100 Î¼g/ml for Flurbiprofen and 10-100 Î¼g/ml for Pantoprazole. The percentage recovery of Flubiprofen was found to be 99.16 and Pantoprazole was found to be 99.46.
Conclusion: The proposed method was validated and can be used for analysis of combined tablet formulation containing Flurbiprofen and Pantoprazole.
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