A MUCOADHESIVE GASTRORETENTIVE DOSAGE FORM FOR VALACYCLOVIR
Objective: The objective of the present work was to formulate a gastroretentive dosage form of Valacyclovir, an anti viral drug.
Methods: Valacyclovir gastroretentive mucoadhesive tablets were prepared using polymers such as Carbopol 974P and hydroxy propyl methyl cellulose (HPMC) K4M, in different proportions by wet granulation technique. Compatibility studies were performed by FTIR spectroscopy. The prepared granules were evaluated for bulk density, Carr's index, Hausner's ratio, friability, drug content uniformity, hardness, thickness and post compression parameters.
Results: Results revealed that all the formulated tablets have acceptable physical properties. Based on the in vitro release profile, the formulation B3, containing HPMC (46%), Carbopol (15%) with a drug release of 96.98% was chosen as the optimized batch. The B3 formulation was subjected for zero order and first order kinetics, Higuchi matrix and peppa's model. It was found to be adherent to the Higuchi model, as the r2 value was higher thereby following Fickian diffusion. Results of in vitro gastric retention time study indicated that the tablet remained adhered to the stomach mucosa and could be seen at the same position after 24h of administration.
Conclusion: The present formulation, i.e. a gastroretentive drug delivery system can be used as an alternative to conventional dosage forms of Valacyclovir with a prospect to increase its residence time in the stomach and decrease its degradation in the intestine thereby increasing its bioavailability.
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