HYPOGLYCEMIC ACTIVITY OF COPERNICIACERIFERA MART.L.EAF POWDER EXTRACT IN THE TREATMENT OF ALLOXAN-INDUCED DIABETIC MICE

  • Paula Alves Salmito Rodrigues Laboratory of Human Biochemistry of the State University of Ceará (1700 Silas Munguba Avenue, Block D, Itaperi Campus, 60740-000)
  • Izabel Florindo Guedes Laboratory of Human Biochemistry of the State University of Ceará (1700 Silas Munguba Avenue, Block D, Itaperi Campus, 60740-000)
  • MÁrcia Maria Mendes Marques Laboratory of Human Biochemistry of the State University of Ceará (1700 Silas Munguba Avenue, Block D, Itaperi Campus, 60740-000)
  • Isaac Neto Goes Da Silva Laboratory of Veterinary Clinical Pathology of the State University of Ceará (1700 Silas Munguba Avenue, Itaperi Campus, 60740-000)
  • Ícaro GusmÃo Pinto Vieira Laboratory of Natural Products (1700 Silas Munguba Avenue, Itaperi Campus, 60740-000)

Abstract

Objective: This study characterizeesters from carnauba crude powder and evaluates its hypoglycemic effect on the treatment of diabetic animals.

Methods: Groups of diabetic micewere induced by alloxan and treated with carnauba crude powder. Blood samples were collected to determine the glucose serum level.

Results: The compound was identified and characterized as diester of the 4-methoxycinnamic acid (PCO-C) and presented hypoglycemic effect in the concentrations of 100 and 150 mg/kgbody weight (b.w. )The concentration 150 mg/kg b.w..o.f PCO-C presented the best effect on controlling glucose levels (p<0.05),when compared to the reference drug.

Conclusion: The results indicate that the PCO-C is a promising therapeutic compound with hypoglycemic effect. This action can be justified by the presence of the diester of 4- methoxycinnamic acid.

 

Keywords: Carnauba wax, Cinnamic acid esters, Diabetes Mellitus.

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Rodrigues, P. A. S., I. F. Guedes, M. M. Mendes Marques, I. N. G. D. Silva, and Pinto Vieira Ícaro G. “HYPOGLYCEMIC ACTIVITY OF COPERNICIACERIFERA MART.L.EAF POWDER EXTRACT IN THE TREATMENT OF ALLOXAN-INDUCED DIABETIC MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 10, 1, pp. 115-8, https://innovareacademics.in/journals/index.php/ijpps/article/view/2256.
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