ROLE OF MICHELIA CHAMPACA IN MEMORY ENHANCEMENT AND ACUTE NOISE STRESSED MALE WISTAR ALBINO RATS


Malathi S., Vidyashree ., Ravindran Rajan

Abstract


Objective: To identify the memory enhancing role of Michelia champaca in acute noise stressed animals.

Methods: Male Wistar albino rats were used in this study. Animals were exposed to noise for 4 h before testing for memory. Thereafter, the plasma corticosterone level and acetylcholinesterase activity were estimated in the discrete regions of the brain, and the memory related behavior were assessed by eight arm radial maze.

Results: Our results showed that Michelia champaca enhances the memory activity and decreases the corticosterone concentrations in acute noise stress animals treated with M. champaca. Moreover, it also decreased brain acetylcholinesterase activity when compared with the acute stress group (p<0.05). Furthermore, behavioral tests indicate that working memory, is enhanced by acute stress and decreases the error levels in all the parameters studied in the behavior aspects when compared to control animals.

Conclusion: These findings suggest that Michelia champaca enhances the memory in albino rats and might be useful therapeutically for cognitive related dysfunctions. This could be due to the presence of memory boosting compounds and its antistressor and anti-acetylcholinesterase activity, thereby reduces the levels of serum corticosterone and inhibition of cholinesterase enzyme significantly.


Keywords


Keywords: M.champaca, memory, corticosterone, acute noise stress, acetylcholinesterase activity, Eight-arm radial maze.

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About this article

Title

ROLE OF MICHELIA CHAMPACA IN MEMORY ENHANCEMENT AND ACUTE NOISE STRESSED MALE WISTAR ALBINO RATS

Keywords

Keywords: M.champaca, memory, corticosterone, acute noise stress, acetylcholinesterase activity, Eight-arm radial maze.

DOI

10.22159/ijpps.2018v10i2.22605

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 2, 2018 Page: 129-135

Online ISSN

0975-1491

Authors & Affiliations

Malathi S.
Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai 600113, Tamil Nadu, India
India

Vidyashree .
Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai 600113, Tamil Nadu, India

Ravindran Rajan
Department of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai 600113, Tamil Nadu, India
India


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