INTERLEUKIN-17INHIBITION WITH SECUKINUMAB IMPROVES SUDOMOTOR DYSFUNCTION IN PSORIATIC ARTHRITIS

  • Ashit Syngle Maharishi Markandeshwar College of Pharmacy, M M University, Ambala, Haryana, India, Fortis Multi Specialty Hospital, Mohali, India,
  • Inderjeet Verma Maharishi Markandeshwar College of Pharmacy, M M University, Ambala, Haryana, India,
  • Sudeep Kaur Department of Kayachikitsa, Postgraduate School of Ayurveda and Research Mandi Gobindgarh, Punjab, India,
  • Tanya Syngle Healing Touch Foundation, Chandigarh, India

Abstract

Psoriatic arthritis (PsA) is a relapsing inflammatory disease, most commonly a seronegative oligoarthritis found in patients with psoriasis, characterized by the absence of rheumatoid factor in serum, with differentiating features of distal joint involvement and in extreme cases of arthritis mutilans (which is a destructive form of PsA). Cardiovascular autonomic and peripheral sympathetic neuropathy occurs in PsA. However, there is no specific treatment recommendation for autonomic neuropathy (AN) in psoriatic diseases. Secukinumab, a recently approved therapeutic advancement for psoriasis and psoriatic arthritis, is an immunoglobulin G (IgG) 1k fully monoclonal antibody that selectively inhibits the effector function of interleukin (IL)-17A. Its effect on sudomotor dysfunction in PsA has not yet been reported. This is the first reported observation of improvement in peripheral sympathetic autonomic neuropathy with secukinumab in PsA. We report a case of a 52-year-old male with PsA on methotrexate 15 mg/week with severe disease activity treated with the addition of subcutaneous secukinumab 150 mg once a week for 5 w followed by once a month dose. We found significant improvement in sudomotor dysfunction after 4 and 8 w of treatment.

Keywords: Psoriatic arthritis, Sudomotor dysfunction, Secukinumab, Autonomic neuropathy, Psoriasis

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References

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How to Cite
Syngle, A., I. Verma, S. Kaur, and T. Syngle. “INTERLEUKIN-17INHIBITION WITH SECUKINUMAB IMPROVES SUDOMOTOR DYSFUNCTION IN PSORIATIC ARTHRITIS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, no. 3, Mar. 2018, pp. 167-9, doi:10.22159/ijpps.2018v10i3.22660.
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