• Parthraj Kshirsagar Department of Botany, Shivaji University, Kolhapur 416004, (MS) India,
  • Tanaji More Department of Biochemistry, Shivaji University, Kolhapur 416004, (MS) India.
  • Akalpita Arvindekar Department of Biochemistry, Shivaji University, Kolhapur 416004, (MS) India.
  • Nikhil Gaikwad Department of Botany, Shivaji University, Kolhapur 416004, (MS) India,


Objective: Oxidative stress and Advanced Glycation End-products have been associated with diabetic complications. Therefore, natural compounds or extracts that possess both antioxidant and anti-glycation activities might have great therapeutic potential for treating diabetic complications.

Methods: The main purpose of this study was to evaluate the total phenolics, total flavonoids, antioxidant, antihyperglycemic and anti-glycation properties of aqueous extracts of some Swertia species from Western Ghats.

Results: The present study revealed that the S. Minor showed the highest amount of total phenolics, total flavonoids and antioxidant activities as compared to other species under study. Swertia angustifolia var. pulchella showed prominent decrease in blood glucose level and the S. lawii distillate showed the highest reduction in fructosamine content with greater anti-glycation property.

Conclusion: All the Swertia species distillate analyzed in this study has exhibited potent hypoglycemic activity. Our study tends to support the traditional use of these medicinally important species and alternative source of diabetic medicines. Further study required to analyze the phytochemicals and their mechanism related to antioxidant, antidiabetic and antiglycation properties.


Keywords: Swertia, Antioxidant, Antihyperglycemic, Anti-glycation.


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1. Altan VM. The pharmacology of diabetic complications. Curr Med Chem 2003;10:1317.
2. Haller H, Drab M, Luft FC. The role of hyperglycemia and hyperinsulinemia in the pathogenesis of diabetic angiopathy. Clin Nephrol 1996;46:246.
3. Vadivelan R, Dipanjan M, Umasankar P, Dhanabal SP, Satishkumar MN, Antony S, et al. Hypoglycemic, antioxidant and hypolipidemic activity of Asparagus racemosus on streptozotocin-induced diabetic in rats. Advan Appl Sci Res 2011;2:179.
4. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405.
5. Bambolkar S, Sainani GS. Evaluation of oxidative stress in diabetics with or without vascular complications. J Assoc Phys India 1995;43:10.
6. Djeridane A, Yousfi M, Nadjemi B, Bouassouna D, Stocker P, Vidal N. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem 2006;97:654.
7. Wais M, Nazish I, Samad A, Beg S, Abusufyan S, Ajaz AS, et al. Herbal drugs for diabetic treatment: an updated review of patents. Recent Pat Anti-Infect Drug Discov 2012;7:53.
8. Nakamura K, Yamagishi SI, Matsui T, Adachi H, Takeuchi M, Imaizumi T. Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are correlated with AGEs in both diabetic and non-diabetic subjects. Clin Exp Med 2007;7:188.
9. Gul A, Rahman MA, Salim A, Simjee SU. Advanced glycation end products in senile diabetic and nondiabetic patients with cataract. J Diab Compli 2009;23:343.
10. Chen Y, Roan H, Lii C, Huang Y, Wang T. Relationship between antioxidant and antiglycation ability of saponins, polyphenols, and polysaccharides in Chinese herbal medicines used to treat diabetes. J Med Plant Res 2011;5:2322.
11. Chhetri DR, Parajuli P, Subba GC. Antidiabetic plants used by Sikkim and Darjeeling Himalayan tribes, India. J Ethnopharmacol 2005;99:199.
12. Li WL, Zheng HC, Bukuru J, Kimpe ND. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004;92:1.
13. Ghosal S, Biswas K, Jaiswal DK. Chemical constituents of Gentianaceae, Part 27, Xanthone and flavonol constituents of Swertia hookeri. Phytochem 1980;19:123.
14. Renu A, Kumar S, Kumar D, Malik A, Kumar T. Antidiabetic activity of ethanolic extract of Swertia chirayita Buch-Ham. Int Res J Pharm 2011;2:230.
15. Alam KD, Ali MS, Mahjabeen S, Hassan MR, Rahman MF, Chowdhury RMAA. Potential hypoglycemic effect of Swertia chirata-an Indian subcontinent herb with important medicinal value. Pharmacologyonline 2011;2:642.
16. Verma VK, Sarwa KK, Zaman MK. Antihyperglycemic activity of Swertia chirayita and Andrographis paniculata plant extracts in streptozotocin-induced diabetic rats. Int J Pharm Pharm Sci 2013;5:305.
17. Basnet P, Kadota S, Shimizu M, Namba T. Bellidifolin: a potent hypoglycemic agent in streptozotocin-induced diabetic rats from Swertia japonica. Planta Med 1994;60:507.
18. Tian LY, Bai X, Chen XH, Fang JB, Liu SH, Chen JC. Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl, and its potential mechanism. Phytomedicine 2010;17:533.
19. Joshi P, Dhawan V. Swertia chirayita-an overview. Curr Sci 2005;89:635.
20. Phoboo S, Jha PK. Trade and Sustainable Conservation of Swertia chirayita (Roxb. ex Fleming) h. Karst in Nepal. Nepal J of Sci and Tech 2010;11:125.
21. Ghosal S, Sharma PV, Chaudhur RK. Tetra and pentaoxygenated xanthones of Swertia lawii. Phytochem 1975;14:1393.
22. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagent. Am J Enol Vitic 1965;16:144.
23. Chang C, Yang M, Wen H, Chen J. Estimation of total flavonoids content in propolis by two complementary colorimetric methods. J Food Drug Analysis 2002;10:178.
24. Lee HC, Kim JH, Jeong SM, Kim DR, Ha JU, Nam KC. Effect of far infrared radiation on the antioxidant activity of rice hulls. J Agri and Food Chem 2003;51:4400.
25. Benzie IFF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”:the FRAP assay. Anal Biochem 1996;239:70.
26. Wu JW, Hsieh CL, Wang HY, Chen HY. Inhibitory effects of guava (Psidium guajava L. ) leaf extracts and its active compounds on the glycation process of protein. Food Chem 2009;113:78.
27. Baker JR, Zyzak DV, Thorpe SR, Baynes JW. Chemistry of the fructosamine assay: D-glucosone is the product of oxidation of Amadori compounds. Clin Chem 1994;40:1950.
28. Selvameena P, Baluprakash T, Arumugasamy K, Kokilavani K, Danya U, Udyashankar MR. Studies on the hypoglycemic and hypolipidemic effect of Swertia minor (Griseb. ) Knobl. (Gentianaceae) – an endemic and endangered medicinal plant from the Nigiris. South Asian J Biol Sci 2011;1:21.
29. Ardestani A, Yazdanparast R. Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. Food Chem Toxicol 2007;45:2402.
30. Shield JP, Poyser K, Hunt L, Pennock CA. Fructosamine and glycated haemoglobin in the assessment of long term glycaemic control in diabetes. Arch Dis Child 1994;71:443.
31. Kedage VV, Tilak JC, Dixit GB, Devasagayam TP, Mhatre M. A study of antioxidant properties of some varieties of grapes (Vitis vinifera L. ). Crit Rev Food Sci Nutr 2007;47:175.
32. Pawar N, Pai S, Nimbalkar M, Dixit G. RP-HPLC analysis of phenolic antioxidant compound 6-gingerol from different ginger cultivars. Food Chem 2011;126:1330.
33. Tung Y, Wu J, Hsieh C, Chen P, Chang S. Free radical-scavenging phytochemicals of hot water extracts of Acacia confusa leaves detected by an on-line screening method. Food Chem 2009;115:1019.
34. Jung M, Park M, Lee HC, Kang Y, Kang ES, Kim SK. Antidiabetic agents from medicinal plants. Curr Med Plants 2006;13:1203.
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How to Cite
Kshirsagar, P., T. More, A. Arvindekar, and N. Gaikwad. “ANTIOXIDANT, ANTIHYPERGLYCEMIC AND ANTIGLYCATION PROPERTIES OF SOME SWERTIA SPECIES FROM WESTERN GHATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 9, 1, pp. 303-6,
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