SYNTHESIS OF DESGLYMIDODRINE FROM MIDODRINE BY CONVENTIONAL AMIDE HYDROLYSIS METHOD


S. T. Narenderan, Srikanth Jupudi, P. Vanaja, S. N. Meyyanathan

Abstract


Objective:  The term prodrug involves chemically modifying inert compound which upon administration releases the active parent drug to elicit its pharmacological response within the body. Acting as a α-adrenergic agonist, desglymidodrine an active metabolite of amide prodrug midodrine is used for the treatment of essential and orthostatic hypotension. In the present study synthesis of desglymidodrine from midodrine was reported.

Methods:  The synthesis was done by the conventional amide hydrolysis method.

Results:  A novel synthesis of desglymidodrine was successfully achieved and spectrally elucidated by infrared spectroscopy (IR), 1H, 13C nuclear magnetic resonance (NMR) and mass analysis.

Conclusion:  The acquired results were found to be accurate, the synthetic route appeared to be simple, cost-effective and time efficient. Hence the synthesized desglymidodrine can be as a reference standard for the estimation of the same.


Keywords


Midodrine, Desglymidodrine, Amide hydrolysis

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About this article

Title

SYNTHESIS OF DESGLYMIDODRINE FROM MIDODRINE BY CONVENTIONAL AMIDE HYDROLYSIS METHOD

Keywords

Midodrine, Desglymidodrine, Amide hydrolysis

DOI

10.22159/ijpps.2018v10i2.23251

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 2, 2018 Page: 168-170

Online ISSN

0975-1491

Authors & Affiliations

S. T. Narenderan
Department of Pharmaceutical Analysis ,JSS College of Pharmacy, Ootacamund, Jagadguru Sri Shivarathreeshwara University, Mysore-643001, India
India

Srikanth Jupudi
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, Jagadguru Sri Shivarathreeshwara University, Mysore-643001, India
India

P. Vanaja
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund, Jagadguru Sri Shivarathreeshwara University, Mysore-643001, India
India

S. N. Meyyanathan
Department of Pharmaceutical Analysis ,JSS College of Pharmacy, Ootacamund, Jagadguru Sri Shivarathreeshwara University, Mysore-643001, India
India


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