EFFICACY OF WATTAKAKA VOLUBILIS AGAINST ALUMINIUM SULPHATE INDUCED IN LIVER TOXICITY


Usharani S., Anuradha R.

Abstract


Objective: The modulation of membrane-bound ATPases, carbohydrate metabolizing enzymes and mitochondrial TCA cycle enzymes in Wattakaka volubilis on aluminium sulphate induced liver toxicity.

Methods: Medicinal therapy requires careful assessment of effective treatment offering an acceptable safety over human health. Experimental animals were divided into five groups (Untreated, negative and positive control, hepatic group and the hepatic group fed on Wattakaka volubilis), Metabolising enzymes level, estimation of DNA, RNA and quantification of DNA fragmentation and gene expression were investigated. These altered enzyme levels were ameliorated significantly by administration of Wattakaka volubilis at the concentration of 200 mg/kg in drug-treated animals.

Results: Results showed that treatment with methanol extract of Wattakaka volubilis normal level of enzymes which are compared with silymarin. This was evident from the significant increase in p<0.05, p<0.01, p<0.001 enzyme levels. Aluminium sulphate induced rats showed decreased the activities of metabolising enzymes and increased DNA fragmentation in the liver. This clearly explained the reason for the hepatoprotective activity of Wattakaka volubilis leaf extract.

Conclusion: The methanolic leaf extract of W. volubilis showed high protective activity against aluminium sulphate-induced hepatotoxicity.


Keywords


Metabolising enzymes, DNA, RNA, DNA fragmentation, W. Volubilis

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About this article

Title

EFFICACY OF WATTAKAKA VOLUBILIS AGAINST ALUMINIUM SULPHATE INDUCED IN LIVER TOXICITY

Keywords

Metabolising enzymes, DNA, RNA, DNA fragmentation, W. Volubilis

DOI

10.22159/ijpps.2018v10i2.23461

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 2, 2018 Page: 136-141

Online ISSN

0975-1491

Authors & Affiliations

Usharani S.
PG & Research Department of Biochemistry, Sengamala Thayaar Educational Trust, Mannargudi 614001 Tamil Nadu, India
India

Anuradha R.
PG & Research Department of Biochemistry, Sengamala Thayaar Educational Trust, Mannargudi 614001 Tamil Nadu, India


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