A REVIEW ON ANTI-INFLAMMATORY POTENTIAL OF SUBSTITUTED PYRAZOLINE DERIVATIVES SYNTHESISED FROM CHALCONES


Muralidharan V., Asha Deepti C., Raja S.

Abstract


  1. The pyrazoline ring is a ubiquitous structural feature of many natural and synthetic compounds with potent anti-inflammatory activity. The creation of novel pyrazoline derivatives and examination of their chemical and biological behaviour have gained additional focus in the current decade. Pyrazolines and its fused heterocyclic derivatives tested with anti-inflammatory activity constitute a significant class of compounds for novel drug evolution. Pyrazoline nucleus when linked with different substituents like alkyl, aromatic, heterocyclic rings and many other groups at different positions on the ring shows considerable to more effective anti-inflammatory activity. This article presents a comprehensive review of the anti-inflammatory activity of some novel derivatives of pyrazoline ring.


Keywords


Pyrazolines, Chalcones, Phenylhydrazine, Thiosemicarbazide, Anti-inflammatory activity, Carrageenan and Cyclooxygenase

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About this article

Title

A REVIEW ON ANTI-INFLAMMATORY POTENTIAL OF SUBSTITUTED PYRAZOLINE DERIVATIVES SYNTHESISED FROM CHALCONES

Keywords

Pyrazolines, Chalcones, Phenylhydrazine, Thiosemicarbazide, Anti-inflammatory activity, Carrageenan and Cyclooxygenase

DOI

10.22159/ijpps.2018v10i2.23772

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 2, 2018 Page: 9-14

Online ISSN

0975-1491

Statistics

71 Views | 25 Downloads

Authors & Affiliations

Muralidharan V.
Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam 530045, AndhraPradesh, India
India

Asha Deepti C.
Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam 530045, Andhra Pradesh, India
India

Raja S.
Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam 530045, Andhra Pradesh, India


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