EFFECT OF MOMORDICA CHARANTIA AND SYZYGIUM CUMINI EXTRACT ON SERUM ELECTROLYTES IN ALLOXAN INDUCED DIABETIC RATS

  • G. Navya Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001, Telangana, India
  • Y. Shirisha Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001, Telangana, India
  • P. Girija Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001, Telangana, India
  • K. Venkateshwarlu Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001, Telangana, India
  • K. Sirisha Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001, Telangana, India

Abstract

Objective: Diabetes is a group of disorders characterized by high blood glucose levels. Disturbances in serum electrolytes like sodium (Na+) and potassium (K+) are found in diabetes. The purpose of the study was to investigate the disturbances in concentrations of serum electrolytes in hyperglycemic crisis and the effect of syzygium cumini and momordica charantia standardized aqueous extracts on serum electrolytes (Na+and K+) in normal and diabetic rats.

Methods: Diabetes is induced by intraperitoneal injection of alloxan at a dose of 120 mg/kg b. w in rats. Rats were divided into 5 groups (normal control, disease control, metformin, test 1 and test 2). In test groups 1 and 2, SASESC (standardized aqueous seed extract of syzygium cumini) and SAFEMC (standardized aqueous fruit extract of momordica charantia) were respectively administered orally to alloxan induced diabetic rats, and their serum electrolyte levels were observed at 1st, 4th, 7th and 14th days.

Results: By the 14thday, the Na+ and K+ levels in groups 4 and 5 were almost normal. However, in group 3 (standard), Na+levels were relatively lower and K+ levels were relatively higher than groups 4 and 5 (test). In group 2 (disease control) as compared to group 1 (normal control), a decrease in Na+ and increase in K+ levels was observed even on day 14.

Conclusion: Treatment with anti diabetic drugs like metformin, syzygium cumini (test-1), momordica charantia (test-2) restored the electrolyte levels almost back to normal over a period of study (14 d). There was significant (**P<0.01, *P<0.05) normalization of electrolyte levels in diabetic rats. It was concluded that syzygium cumini and momordica charantia showed better efficiency in restoring the electrolyte imbalance as compared to metformin during our study.

Keywords: Syzygium cumini, Momordica charantia, Metformin, Diabetes, Electrolyte, Alloxan

Downloads

Download data is not yet available.

Author Biography

G. Navya, Department of Pharmaceutical Analysis, Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal-506001, Telangana, India
Department of Pharmacuetical Analysis

References

1. Clinical practice guidelines expert committee. Diagnosis, classification, and diagnosis of diabetes, pre-diabetes and metabolic syndrome. Can J Diabetes 2013;37:S8-11.
2. Diagnosis and classification and diagnosis of diabetes mellitus. Diabetes Care 2010;33:S62-9.
3. Wikipedia contributors. Wikipedia, the Free Encyclopedia. San Francisco: Wikimedia Foundation, Inc; 2004.
4. Talabani N. Serum electrolytes and lipid profile in non–insulin dependent diabetes mellitus patients. Asian J Med Sci 2014;6:38-1.
5. Liamis G, Liberopoulos E, Barkas F, Elisaf M. Diabetes mellitus and electrolyte disorders. World J Clin Cases 2014;2:488-6.
6. Sotirakopoulos N, Kalogiannidou I, Tersi M, Armentzioiou K, Sivridis D, Mavromatidis Kl. Acid–base and electrolyte disorders in patients with diabetes mellitus. Saudi J Kidney Diseases Transplantation 2012;23:58-2.
7. Biff FP, Deborah JC. Electrolyte and acid–base disturbance in patients with diabetes mellitus. New Eng J Med 2015;373:548-9.
8. Husain F, Arif Maan M, Sheikh MA, Nawaz H, Jamil A. Trace elements status in type 2 diabetes. Bangladesh J Med Sci 2009;8:52–6.
9. Lowery JM, Eichberg J, Saubermann AJ, LoPachin RM. Distribution of elements and water in peripheral nerve of streptozocin-induced diabetic rats. Diabetes 1990;39:1498-3.
10. Nabeel MS. Effect of an extract of phoenx dactylifera palm leaves on some blood serum electrolytes in alloxan induced female rats. Int J Adv Res 2014;2:731-6.
11. Agoda PO, Braide VB. Effect of dietary garcinia kola seed on serum electrolytes and trace elements in male albino rats. J Physiol Sci 2011;24:53-7.
12. Omigie IO, Agoreyo FO. Effects of citrullus lanatus seed on blood glucose and electrolyte parameters in diabetic induced Wistar rats. J Appl Environ Management 2014;18:231-3.
13. Singh N, Gupta M. Ethanolic extract of syzygium cumini seed powder on pancreatic islets of alloxan diabetic rats. Indian J Exp Biol 2007;45:861-7.
14. Kitabchi AE, Umpierre GE, Murphy MB, Kriesberg RA. Hyperglycemic crisis in adult patients with diabetes: a consensus statement from the American diabetes association. Diabetes Care 2006;29:2739–8.
15. Wang S, Hou XH, Liu Y, Lu HJ, Wei L, Bao YQ, et al. Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus. Cardiovasc Diabetol 2013;12:146-6.
16. Haglin L, Backman L, Tornkvist B. A structural equation model for assessment of links between changes in serum triglycerides, urate, and glucose and changes in serum calcium, magnesium, and phosphate in type 2 diabetes and non-diabetes metabolism. Cardiovasc Diabetol 2011;10:116-4.
17. Uribarri J, Oh MS, Carroll HJ. Hyperkalemia in diabetes mellitus. J Diabet Complications 1990;4:3-7.
18. Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K. Use of gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;130:281-4.
19. Sheweita SA, Newairy AA, Mansour HA, Yousef MI. Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats. Toxicology 2002;174:131-9.
20. Srikanta S, Gando O, Eisenbarth G, Stoeldner J. Islet-cell antibodies and beta-cell function in monozygotic tripleta and twins initially discordant for type I diabetes mellitus. N Engl J Med 1983;388:322-5.
21. Torres IC, Suarez JC. A preliminary study of hypoglycemic activity of lythrum salicaria. J Nat Prod 1980;43:559-3.
22. Veiga F, Fernandes C, Teixeira F. Oral bioavailability and hypoglycemic activity of tolbutamide/cyclodextrin inclusion complexes. Int J Pharm 2000;202:165-1.
23. Liamis G, Liberopoulos E, Barkas F, Elisaf M. Diabetes mellitus and electrolyte disorders. World J Clin Cases 2014;2:488-6.
24. Ngugi MP, Njagi MJ, Kibiti MC, Ngeranwa JNJ, Njagi NME, Njue MW, et al. Herbal management of diabetes mellitus. Int J Curr Pharm Res 2012;2:1-4.
Statistics
123 Views | 328 Downloads
Citatons
How to Cite
Navya, G., Y. Shirisha, P. Girija, K. Venkateshwarlu, and K. Sirisha. “EFFECT OF MOMORDICA CHARANTIA AND SYZYGIUM CUMINI EXTRACT ON SERUM ELECTROLYTES IN ALLOXAN INDUCED DIABETIC RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, no. 11, Nov. 2018, pp. 24-27, doi:10.22159/ijpps.2018v10i11.24963.
Section
Original Article(s)