• Vasudeva Reddy Nagavelli Department of Chemistry, Kakatiya University, Warangal 506009 India.
  • Kumaraswamy B Department of Chemistry, Kakatiya University, Warangal 506009 India.
  • Ranjith Kumar T Department of Chemistry, Kakatiya University, Warangal 506009 India.
  • Narsimha S Department of Chemistry, Kakatiya University, Warangal 506009 India.


Objective: Synthesis and antimicrobial evaluation of some new amides of Thiomorpholine caboxylate.

Methods: A series of new amides of Thiomorpholine caboxylate were synthesized by reacting 4-tert-butyl 2-methyl thiomorpholine-2,4-dicarboxylate 1,1-dioxide with primary amines in presence of Trimethyl aluminum in toluene at ambient temperature in good yields. 4-tert-butyl 2-methyl thiomorpholine-2,4-dicarboxylate 1,1-dioxide was synthesized by reacting tert-butyl thiomorpholine-4-carboxylate 1,1-dioxide with methyl chloroformate in presence of LiHMDS (1M in THF) at -78oC for the first time. The newly synthesized compounds were characterized by IR, 1HNMR, 13C NMR, Mass spectral studies and elemental analysis.

Results: A series of new amides of Thiomorpholine carboxylate were synthesized in good yields and all the compounds were screened for their In-vitro antimicrobial activities.

Conclusion: Preliminary results revealed that the synthesized compounds were showed moderate to good antibacterial and antifungal activity.

Keywords: Antimicrobial activity, Thiomorpholine, Trimethylaluminum, LiHMDS.


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Author Biography

Vasudeva Reddy Nagavelli, Department of Chemistry, Kakatiya University, Warangal 506009 India.


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How to Cite
Nagavelli, V. R., K. B, R. K. T, and N. S. “SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIMICROBIAL EVALUATION OF SOME NEW AMIDES OF THIOMORPHOLINE CARBOXYLATE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 9, 1, pp. 418-21,
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