SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF 1, 3, 4-THIADIAZOLE DERIVATIVES

Authors

  • Arup Naskar Jadavpur University
  • Tanushree Singha Jadavpur University
  • Tanmoy Guria Jadavpur University
  • Jagadish Singh Guru Ghasidas Vishwavidyalaya
  • Ashok Kumar B ASIA Metropolitan University
  • Tapan Kumar Maity Jadavpur University

Keywords:

1, 3, 4-Thiadiazole, Anticancer activity, Tumor cell count, Tumor weight inhibition

Abstract

Objective: N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine derivatives: Synthesis and anticancer activity.

Methods: In the present study five new derivatives of N-benzylidene-5-phenyl-1, 3, 4-thiadiazol-2-amine (Schiff bases containing 1, 3, 4-thiadiazole) were synthesized according to the literature methods and were characterized by FT-IR, 1H NMR spectroscopy and C, H, N analysis. Anticancer activity was evaluated in Male Swiss albino mice using Ehrlich's Ascites carcinoma cells. Compounds were administered at a dose of 25 mg/kg, body weight intraperitoneally.

Results: The compounds were found to reduce tumor volume, viable cell count and increase the tumor weight (%) inhibition, ascites cells (%) inhibition, non-viable cell count and increase in life span (%ILS). All the compounds exhibited significant (P< 0.01) anticancer activity compared to control and the compound 2d & 4d was found to be most potent.

Conclusion: It is concluded that synthesized Schiff bases of 2-amino-5-aryl-1, 3, 4-thiadiazoles derivatives are biologically active and developed into useful anticancer agents.

 

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Published

01-03-2015

How to Cite

Naskar, A., T. Singha, T. Guria, J. Singh, A. K. B, and T. K. Maity. “SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTICANCER ACTIVITY OF SOME NEW SCHIFF BASES OF 1, 3, 4-THIADIAZOLE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 3, Mar. 2015, pp. 397-02, https://innovareacademics.in/journals/index.php/ijpps/article/view/2538.

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