STABILITY INDICATING RP HPLC METHOD FOR THE ESTIMATION OF ARMODAFINIL IN TABLET DOSAGE FORM

Authors

  • P. Vivek Sagar Department of Pharmaceutical Analysis Care College of pharmacy, Oglapur (v), Atmakur (M), Warangal Telangana, India
  • Nelofer Bagum Department of Pharmaceutical Analysis Care College of pharmacy, Oglapur (v), Atmakur (M), Warangal, Telangana, India
  • S. Shobha Rani Department of Pharmaceutical Analysis Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

Keywords:

Armodafinil, RP HPLC, Stability indicating assay, Validation

Abstract

Objective: To develop simple reverse phase HPLC method for the estimation of Armodafinil in tablet dosage form.

Methods: Chromatography was performed by isocratic elution on a Stainless steel Hibar C18 column with dimensions 4.6 x 250 mm, packed with octadecylsilane bonded to porous silica (C18) with particle size 5 micron. Acetonitrile and water in the ratio of 50:50 v/v is used as mobile phase. The flow rate is 1.0 ml/ min and effluent is monitored at 220 nm. Armodafinil was eluted at a retention time of 3.8 minutes.

Results: The standard curve of Armodafinil was linear over a working range of 1–700 µg/ml and gave an average correlation coefficient of 0.999. The limit of quantitation (LOQ) of the drug is 0.1 µg/ ml. Recovery studies were carried out by standard addition method and the recoveries are found satisfactory within the range of 99.3 to 101.5 %. The method is precise with % RSD below

Conclusion: The method is validated in terms of robustness and forced degradation studies were carried out and this method can be applied for routine degradation studies ans quantification in regular laboratories.

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Published

31-08-2014

How to Cite

Sagar, P. V., N. Bagum, and S. S. Rani. “STABILITY INDICATING RP HPLC METHOD FOR THE ESTIMATION OF ARMODAFINIL IN TABLET DOSAGE FORM”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 604-9, https://innovareacademics.in/journals/index.php/ijpps/article/view/2766.

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