EXPLORING THE COMPETENCE OF PHYTOCHEMICAL COMPOUNDS TO COMBAT ANTHRACNOSE DISEASE OF CUCUMBER -AN IN SILICO APPROACH

Authors

  • K. Priyadharsini Department of Plant Molecular Biology and Bioinformatics, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, India.
  • S. Saravanakumar Department of Plant Molecular Biology and Bioinformatics, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, India.
  • N. Bharathi Department of Plant Molecular Biology and Bioinformatics, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, India.
  • J. Ramlingam Department of Plant Molecular Biology and Bioinformatics, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, India.

Keywords:

Anthracnose, Colletotrichum lagenarium, Melanin, Scytalone dehydratase, Phytochemical

Abstract

Objective: Anthracnose is one of the diseases of cucumber caused by the fungus Colletotrichum lagenarium. The enzymes of fungal melanin biosynthesis pathway act as a potential target for the synthetic fungicides. The present study aims to identify the rational phytochemical compound that exhibits inhibitory activity towards a key enzyme scytalone dehydratase (SCD) of melanin biosynthesis pathway.

Methods: Phytochemical compounds with antifungal activity were screened from the conventionally used medicinal plants and docked with the target enzyme SCD.

Results: The interaction amongst phytocompounds and the target SCD were evaluated. Five out of 20 compounds exhibited higher binding affinity compared to that of synthetic fungicide carpropamid.

Conclusion: The current study revealed that the compounds exhibiting significant interaction with SCD might act as an efficient fungicide for the control of anthracnose disease of cucumber.

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Published

31-08-2014

How to Cite

Priyadharsini, K., S. Saravanakumar, N. Bharathi, and J. Ramlingam. “EXPLORING THE COMPETENCE OF PHYTOCHEMICAL COMPOUNDS TO COMBAT ANTHRACNOSE DISEASE OF CUCUMBER -AN IN SILICO APPROACH”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 255-8, https://innovareacademics.in/journals/index.php/ijpps/article/view/2773.

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