NANOSTRUCTURED LIPID CARRIERS (NLCS): A PROMINENT TOPICAL DELIVERY SYSTEM FOR COENZYME Q10 AND MYRICA ESCULENTA LEAVES EXTRACT FOR ANTI-AGING POTENTIAL

  • Prashant Kumar Department of Pharmaceutical Sciences, Kumaun University Bhimtal, Uttarakhand, India 263136
  • Anita Singh Department of Pharmaceutical Sciences, Kumaun University Bhimtal, Uttarakhand, India 263136

Abstract

Objective: In this study, Myrica esculenta (ME) leaves extract along with Coenzyme Q10 was entrapped in nanostructured lipid carriers (NLCs). The formulation variables were successfully optimized using 23 factorial design.

Methods: Preparation of NLC was carried out by solvent injection technique. The formulation of NLC was consisting of the methanolic extract of Myrica esculenta leaves and Coenzyme Q10 as key ingredients. Oleic Acid (OA) was taken as liquid lipid, Precirol ATO 5 (PATO) as solid lipid, and Poloxamer 407 (P407). The formulation variables were statically optimized using 23 factorial design, followed by the characterization of the formulation.

Results: The results demonstrated that the best optimized NLC formulation F5 of Coenzyme Q10 and plant extract exhibited the smallest size 169.46 nm and highest entrapment efficiency 90.06±0.171 %. Furthermore, it showed good physical stability at 28 d after preparation.

Conclusion: The developed NLCs of Q10-ME extract from this study could be explored as the effective anti-ageing formulation.

Keywords: Anti-aging cosmetics, Antioxidant activity, Factorial design nanostructured lipid carriers

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Kumar, P., and A. Singh. “NANOSTRUCTURED LIPID CARRIERS (NLCS): A PROMINENT TOPICAL DELIVERY SYSTEM FOR COENZYME Q10 AND MYRICA ESCULENTA LEAVES EXTRACT FOR ANTI-AGING POTENTIAL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 10, no. 8, Aug. 2018, pp. 106-12, doi:10.22159/ijpps.2018v10i8.27745.
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