• Marwa Shukr Department of pharmaceutics, National Organization for Drug Control and Research, Egypt.
  • Amal Abdel Rahim Department of pharmaceutics, National Organization for Drug Control and Research, Egypt.


Ketorolac tromethamine, Adhesive buccal tablets, Mucoadhesive polymers


Objective: The aim of the present study was to develop and evaluate buccal mucoadhesive tablets of ketorolac tromethamine.

Methods: The tablets were prepared by direct compression using bioadhesive polymers such as carbobpl 934 with hydroxylpropyl methylcellulose K4M and sodium carboxymethyl cellulose. The prepared tablets were characterized by different parameters such as weight uniformity, content uniformity, hardness, swelling index, in vitro drug release studies, ex- vivo residence time and ex- vivo permeation study.

Results: F7 formulation containing Carbopol 934 and SCMC (at the ratio 1:3, respectively) showed good swelling, a convenient residence time as well as the highest amount of drug released within 6 hrs. Stability studies in natural saliva for 6 hrs, indicated that optimized F7 formulation has good stability in human saliva. In addition to the good correlation obtained between in vitro drug release and ex-vivo drug permeation study.

Conclusion: The buccal mucoadhesive tablet of ketorolac could be an alternative route to reduce the pronounced gastrointestinal irritations, reduce dosing frequency to improve patient complains.


Download data is not yet available.


Singh B, Chakkal S K, Ahuja N. Formulation and Optimization of Controlled Release Mucoadhesive Tablets of Atenolol Using Response Surface Methodology. J AAPS Pharm Sci Tech 2006;7:1.

Hao J, Heng PWS. Buccal delivery systems Drug Dev. Ind Pharm 2003;29(8):821-32.

Patel VM, Prajapati BG, Patel M M. Formulation, evaluation, and comparision of bilayered and multilayered mucoadhesive buccal devices of propranolol hydrochloride. J AAPS Pharm Sci Tech 2007;8:1.

Hoogstraate JAH, Wertz PW. Drug delivery via the buccal the buccal mucosa. J Pharm Sci Tech Today 1998;1:(7):309-16.

5 Metia PK, Bandyopadhyay AK. In-vitro Evaluation of Novel Mucoadhesive Buccal Tablets of Oxytocin prepared with Diospyros Peregrine Fruits Mucilages. YAKUGAKU ZASSHI. The J Pharm Society of Japan 2008;128(4):603-9.

Angeles Gonzalez-Fernandez M. Appropriateness of Ketorolac use in a trauma hospital. J Rev Calid Asist 2009;24:115-23.

Catapano MS. The analgesic efficacy of ketorolac for acute pain. J Emerg Med 1996;14:67-75.

Vitale MG, Choe JC, Hwang MW, Bauer RM, Hyman JE, Lee FY, Roye DP. Use of ketorolac tromethamine in children undergoing scoliosis surgery:an analysis of complications. Spine J 2003;3:55-62.

Bottenberg P, Cleymaet R, Muynek CD, Remon JP, Coomans D, Slop D. Development and testing of bioadhesive, fluoride-containing slow-release tablets for oral use. J Pharm Pharmacol 1991;43:457-64.

Parodi B, Russo E, Caviglioli G, Cafaggi S, Bignardi G. Development and characterization of a buccoadhesive dosage form of oxycodone hydrochloride. J Drug Dev Ind Pharm 1996;22:445-50.

Yamagar M, Kadam V, Hirlekar R. Design and evaluation of buccoadhesive drug delivery system of Metoprolol Tartrate. Int J Pharm Tech Res 2010;2(1):453â€62.

Samani SM, Najafi RB, Yousefi G. Formulation and in vitro evaluation of prednisolone buccoadhesive tablets. J Il Farmaco 2005;60:339–44.

Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. J Pharm Acta Helv 1985;60:110-11.

Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13(2):123–33.

Han RY, Fang JY, Sung KC, Hu OYP. Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery:effect of formulation variables on drug release and mucoadhesive performance. Int J Pharm 1999;177(2):201-9.

Yamsani VV, Gannu R, Kolli C, Rao MEB, Yamsani MR. Development and in vitro evaluation of buccoadhesive carvedilol tablets. J Acta Pharm 2007;57:185â€97.

Peh KK, Wong CW. Polymeric films as vehicle for buccal delivery:swelling, mechanical, and bioadhesive properties. J Pharm Pharm Sci 1999;2(2):53-61.

Mortazavi SA, Aboofazeli R. Preparation and in-vitro assessment of various mucosa delivery J DARU 2000;8:9-18

Deasy PB, O,Neill CT. Bioadhesive dosage form for peroral administration of timolol base. J Pharm Acta Helv 1989;64:231.



How to Cite

Shukr, M., and A. A. Rahim. “DEVELOPMENT AND EVALUATION OF KETOROLAC TROMETHAMINE MUCOADHESIVE BUCCAL TABLETS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 294-8,



Original Article(s)