A STUDY ON EVALUATION OF POTASSIUM ABNORMALITIES IN A TERTIARY CARE HOSPITAL

  • K. RAWHEENA MAYEE Department of Pharmacy Practice, Sri Venkateshwara College of Pharmacy, Affiliated Osmania University, Hyderabad, Telangana, India
  • Vidhya Maheshwaram Sri Venkateshwara College of Pharmacy
  • Sahithya Kamjula Sri Venkateshwara College of Pharmacy
  • K. Srujana Sri Venkateshwara College of Pharmacy
  • Naveen Kumar Vasa Sri Venkateshwara College of Pharmacy
  • Aparna Yerramilli Department of Pharmacy Practice, Sri Venkateshwara College of Pharmacy, Affiliated Osmania University, Hyderabad, Telangana, India
  • Sanjeev Sharma Clinical Pharmacologist, Apollo Hospitals, Hyderabad, Telangana, India

Abstract

Objective: To study the occurrence, causes, predisposing factors and management of potassium abnormalities in a tertiary care hospital.


Methods: Inour studywhich was for aduration of six months, we recorded patient demographics, electrolyte levels, complete blood picture, liver function tests, renal parameters, comorbid conditions,medication reconciliation and electro cardio gram (ECG) changes. The data was analyzed to find out the cause for potassium abnormality and was categorize based on their severity.


Results:A total of 200 cases of potassium abnormalities was normalized during the study period. We observed158(80%)cases with hypokalemia, 37 (17%) cases with hyperkalemia and 5 (3%) caseswith subsequentPotassium abnormalities. We observed the majority of hypokalemiaarewith disease induced 87(55.06%) cases and 118 (74.0%)cases were with mild hypokalemia. Syruppotassium chloride was usedto normalize the serum potassium levels. Majority of the hyperkalemia cases were disease induced and was found in 19(51.35%)cases and 22 (59.45%) casescome under mild categorywhich was managed with injection calciumgluconate.


Conclusion: Hypokalemia was the most common potassium abnormality seen in hospitalized patients.Disease inducedpotassium abnormalitieswas found to be more common in both hypo and hyperkalemia. The potassium levels were normalized with no major negative outcomes. Continuous monitoring of electrolyte levels is required for the patient to prevent further complications.

Keywords: Hypokalemia, Hyperkalemia, Disease induced, Drug-induced, Potassium supplements

Downloads

Download data is not yet available.

References

1. OlubunmiCOjo, ModupeFAsaolu. Status of plasma electrolytes, urea, creatinine, andc-reactive protein in cancer patients. Asian J Pharm Clin Res2018;11:268-70.
2. Lawrence JAppel, David H, Baker Potassium. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, dc: the national academies Press; 2005. p. 186-268.
3. RobertJ luft, Friedrich C Shirley.Pathophysiology and management of hypokalemia: a clinical perspective.National Rev Nephrol 2011;10:2010-75.
4. Marjorie JArca, Brian Kenney. The management of hyperkalemia in the emergency department.J Accident Emergency Med2010;17:181-92.
5. Cohn JN, Kowey PR, Whelton PK, Prisant LM. New guidelines for potassium replacement in clinical practice a contemporary review by the national council on potassium in clinical practice. Arch Intern Med2000;160:2429–36.
6. Matsui H, Shimosawa T, Uetake Y, Wang H, Ogura S, Kaneko T, et al. Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction. Hypertension2006;48:225-31.
7. Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ,et al. AHA dietary guidelines. Revision 2000:a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Stroke 2000;31:2751-66.
8. David B Mount. Fluid and electrolyte disturbances. ln: Jameson Fauci, Braunwald, Kasper. editors. Harrison’s principles of internal medicine.20thed.New York: McGraw-Hill, Medical Pub. Division; 2005;46:281-96.
9. HarikeshMaurya. Tirath Kumar.A review on comprehensive overview in the management of nephrotic disorders. J Critical Rev 2016;3:34-43.
Statistics
188 Views | 179 Downloads
Citatons
How to Cite
MAYEE, K. R., V. Maheshwaram, S. Kamjula, K. Srujana, N. K. Vasa, A. Yerramilli, and S. Sharma. “A STUDY ON EVALUATION OF POTASSIUM ABNORMALITIES IN A TERTIARY CARE HOSPITAL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 4, Mar. 2019, pp. 104-7, doi:10.22159/ijpps.2019v11i4.28033.
Section
Original Article(s)