TRITERPENOID SAPONINS: A REVIEW ON BIOSYNTHESIS, APPLICATIONS AND MECHANISM OF THEIR ACTION


Vasudeva Reddy Netala, Sukhendu Bikash Ghosh, Pushpalatha Bobbu, Dandu Anitha, Vijaya Tartte

Abstract


Saponins are the potential bioactive compounds secreted by plants, endophytic fungi and marine organisms. Saponins are the glycosides containing non sugar portion, aglycone (sapogenin) attached to sugar moiety by glycosidic linkage. Depending on the chemical nature of aglycone, saponins are of triterpenoid and steroid saponins. The present review gives an overview of the biosynthesis pathway of triterpenoid saponins and mechanism of the biosynthesis. The review discusses the biomedical and pharmaceutical importance of triterpenoid saponins as they possess different activities including antimicrobial, haemolytic, hypolipidemic, immunomodulating and cytotoxic activities. The review also focuses on the mechanism of their action towards various activities.

 


Keywords


Triterpenoid saponins, Biomedical importance, Cell cytotoxicity, Immunomodulating activity.

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About this article

Title

TRITERPENOID SAPONINS: A REVIEW ON BIOSYNTHESIS, APPLICATIONS AND MECHANISM OF THEIR ACTION

Keywords

Triterpenoid saponins, Biomedical importance, Cell cytotoxicity, Immunomodulating activity.

Date

17-11-2014

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 1, 2015 Page: 24-28

Online ISSN

0975-1491

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3020 Views | 1621 Downloads

Authors & Affiliations

Vasudeva Reddy Netala
Sri Venkateswara University
India

Sukhendu Bikash Ghosh
Nuclear Agriculture and Biotechnology Division
India

Pushpalatha Bobbu
Sri Venkateswara University
India

Dandu Anitha
Sri Venkateswara University
India

Vijaya Tartte
Sri Venkateswara University
India


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