• D. Sivakumar PPG College of Pharmacy, Saravanampatti, Coimbatore, Tamilnadu, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamilnadu
  • G. Geetha PPG College of Pharmacy, Saravanampatti, Coimbatore, Tamilnadu, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamilnadu



Thiadiazole derivatives, molecular docking, Schroodinger software, ligand binding energy, protein kinase G enzyme, mycobacterium tuberculosis


Objective: In the present study, a novel series of 1, 3, 4-thiadiazole derivatives were docked against the mycobacterium tuberculosis protein kinase G. 1, 3, 4–thiadiazole derivatives with a modified primary amine group at 5th position were used for docking studies.

Methods: The three-dimensional structure of the protein was obtained from PDB, and its active sites were predicted. The structures of all the compounds were drawn using chemdraw software version 8.0. The docking studies were done by using schrödinger software against the enzyme protein kinase G. Totally eighteen compounds was synthesized based on glide score

Results: In this Docking study the thiadiazole analogues were showing good binding energy. The amino acids residues GLU588, SER412, GLY410 and GLU 628 in the kinase domain active site form hydrogen bonds with the ligand.

Conclusion: The compounds D34, D16, D7, D25, D15, and D27 showed better interaction with protein kinase G (pknG) more than the other drug molecules


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How to Cite

Sivakumar, D., and G. Geetha. “MOLECULAR DOCKING STUDIES ON THIADIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 10, no. 12, Dec. 2018, pp. 70-74, doi:10.22159/ijpps.2018v10i12.28948.



Original Article(s)