LC-MS/MS STUDY OF THE TRACE LEVEL IMPURITIES OF IRBESARTAN AN ANGIOTENSIN II RECEPTOR ANTAGONIST MOLECULE TO ITS ORIGIN THROUGH nMS2 TECHNIQUE

  • S. Saravanan Research and Development Centre, Bharathiar University, Coimbatore, India
  • A. Taminum Ansari Indian Institute of Chromatography & Mass Spectrometry, Spinco Biotech, Spinco Towers, Chennai, India

Abstract

Objective: The mass characterization of five trace level related impurities of Irbesartan was performed through the “nMS2†technique of triple quadrupole mass spectrometer and also to Correlated to the impurity origin.

Methods: A simple & effective patented process was applied to get the impurity profile, and mass characterization was performed through the “nMS2†technique of triple quadrupole mass spectrometer analyser.

Results: The simple production scan in differential collision energies is coined as “nMS2†technique of the triple quadrupole analyzer. The molecular ion fragmentation occurs with multiple collision energies and provides meaningful MSMS fragments for characterizing five trace level impurities less than 0.5% of angiotensin II receptor antagonist-Irbesartan. The origin of the impurity formation in the synthetic process was successfully related to the Spiro ketones.

Conclusion: The results obtained in this research clearly indicates the approach of “nMS2†technique was very useful in the identification and structural prediction of trace level related impurities of Irbesrtan.

Keywords: nMS2technique, Irbesartan, LCMSMS of Irbesartan, Impurity Characterization

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How to Cite
Saravanan, S., and A. Ansari. “LC-MS/MS STUDY OF THE TRACE LEVEL IMPURITIES OF IRBESARTAN AN ANGIOTENSIN II RECEPTOR ANTAGONIST MOLECULE TO ITS ORIGIN THROUGH NMS2 TECHNIQUE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 1, Jan. 2019, pp. 38-43, doi:10.22159/2019v11i1.29037.
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