• Liew Kai Bin Faculty of Pharmaceutical Sciences, UCSI University. No 1, Jalan Menara Gading, UCSI Height, 56000 Cheras, Kuala Lumpur
  • Anand Gaurav Faculty of Pharmacy, Cyberjaya University College of Medical Sciences. Persiaran Bestari, 63000 Cyberjaya, Selangor
  • Uttam Kumar Mandal Department of pharmaceutical sciences & Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, Punjab 151001, India


There is no single-component excipient fulfills all the requisite performance to allow an active pharmaceutical ingredient to be formulated into a specific dosage form. Co-processed excipient has received much more attention in the formulation development of various dosage forms, specially for tablet preparation by direct compression method. The objective of this review is to discuss the emergence of co-processed excipients as a current and future trend of excipient technology in pharmaceutical manufacturing. Co-processing is a novel concept of combining two or more excipients that possess specific advantages that cannot be achieved using a physical admixture of the same combination of excipients. This review article discusses the advantages of co-processing, the need of co-processed excipient, general steps in developing co-processed excipient, limitation of co-processed excipient, technologies used in developing co-processing excipients, co-processed excipients in the literature, marketed products and future trends. With advantages offered by the upcoming newer combination of excipients and newer methods of co-processing, co-processed excipients are for sure going to gain attraction both from academia and pharmaceutical industry. Furthermore, it opens the opportunity for development and use of single multifunctional excipient rather than multiple excipients in the formulation.

Keywords: Orally disintegrating tablet, Oral drug delivery, Co-processed excipient, Direct compression


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1. Godbole AM, Somnache SN, Thakker SP, Iliger SR, Patel BV, Suryawanshi SD. Coprocessed directly compressible excipients: a review. Uni J Pharm 2013;2:57-70.
2. Atul P, Subrata K, Ganga S. A review on co-processed excipients: a novel approach in formulation development. IJRAPI 2013;3:25-41.
3. The International Pharmaceutical Excipient Council Excipient Composition Guide. Europe; 2009.
4. Chaudhari PD, Phatak AA, Desai U. A review: co-processed excipients–an alternative to novel chemical entities. Int J Pharm Chem Sci 2012;1:1480-98.
5. Chukwu A. Key points in pharmaceutical formulation and industrial pharmacy. Nsukka: Mike Social Press; 2001. p. 1-5.
6. Nachegari SK, Bansal AK. Coprocessed excipients for solid dosage forms. Pharm Tech 2004;28:52-64.
7. Okore VC, Adikwu MU. Application of polymers in pharmaceutical sciences. In: Polymers and polymer applications. Nsukka: Jolyn Publishers; 2009. p. 49-63.
8. Reimerdes D, Aufmuth KP. Tableting withcoprocessed lactose-cellulose excipient. Manufac Chem 1992;63:23-4.
9. Patel SS, Patel NM. Recent trends in direct compression technology. Pharma Buzz 2007;2:24-34.
10. Pakhale BA, Shinkar DM, Saudagar RB. Co-processed excipient: an overview. World J Pharm Res 2014;4:454-69.
11. Tobyn MJ, McCarthy GP, Staniforth JN, Edge S. Physicochemicalcomparison between microcrystalline cellulose and silicified microcrystalline cellulose. Int J Pharm 1998;169:183–94.
12. Ugoeze KC, Nkoro VO. The physico-technical properties of a multicomponent Lentinus tuberregium based co-processed excipient (Fizlent). Am J Pharma Pharmacol 2015;2:13-20.
13. Michael J, Tobyn GP, McCarthy I, John N, Staniforth SE. Physicochemical comparison between microcrystalline cellulose and silicified microcrystalline cellulose. Int J Pharm 1998;169:183-94.
14. Sudhir B, Vinay J, Shailesh S. Orally disintegrating tablets: a review. Drug Invent Today 2010;2:81-8.
15. Moreton RC. Tablet excipients to the year 2001: a look into thecrystal ball. Drug Dev Ind Pharm 1996;22:11-23.
16. Rasenack N, Muller BW. Crystal habit and tableting behavior. Int J Pharm 2002;244:45-57.
17. Liew KB, Peh KK, Tan YTF. Orally disintegrating dosage forms: breakthrough solution for non-compliance. Int J Pharm Pharm Sci 2013;5:4-8.
18. Shangraw RF, Leiberman HA, Lachman L, Schwatz JB. Pharmaceutical dosage forms: tablets. New York: Marcel Dekker; 1990. p. 195-246.
19. Shangraw RF, Demarest DA. A survey of current industrial practicesin the formulation and manufacture of tablets and capsules. Pharm Tech 1993;17:32-44.
20. Norman AA. Tablet manufactured by direct compression. Encyclopedia of pharmaceutical technology. New York: Informa Healthcare USA; 2007;6:3673.
21. Banker UV. Role of ingredients and excipients in developing pharmaceuticals. Manufact Chem 1994;65:32-4.
22. Rubinstein MH. Tablets pharmaceutics: the science of dosage of form. 1st edition. UK: Churchill; 1998. p. 304-21.
23. York P. Crystal engineering and particle design for the powder compaction process. Drug Dev Ind Pharm 1992;18:677-721.
24. Marwaha M, Sandhu D, Marwaha RK. Coprocessing of excipients: a review on excipient development for improved tabletting performance. Int J Appl Pharm 2010;2:41-2.
25. Flores LE, Arellano RL, Esquivel JJD. Study of load capacity of Avicel PH200 and cellactose, two direct compression excipients, using an experimental design. Drug Dev Ind Pharm 2000;26:465–9.
26. Jivraj M, Martini LG, Thomson CM. An overview of the different excipients useful for the direct compression of tablets. Pharm Sci Technol Today 2000;3:58-63.
27. Sherwood BE, Becker JW. A new class of high functionality excipients: silicified microcrystalline cellulose. Pharm Tech 1988;22:78–88.
28. Smewing J. Powder flow analysis-the solution. Manufact Chem 2002;73:32-3.
29. Ambore SM, Tekale J, Gattani SG. Investigation of novel multifunctional co-processed excipient for direct compression. World Appl Sci J 2014;31:801-10.
30. Belda PM, Mielck JB. The tableting behavior of Cellactose compared with mixtures of celluloses with lactoses. Eur J Pharm Biopharma 1996;42:325–30.
31. Patel RP, Bhavsar M. Direcetly compressible materials via co-processing. Iran J Pharm Res 2009;1:745-53.
32. Reimerdes D. The near future of tablet excipients. Manufact Chem 1993;64:14–5.
33. Armstrong NA, Palfrey LP. The effect of machine speed on the consolidation of four directly compressible tablet diluents. J Pharm Pharmacol 1989;41:149.
34. Marwaha M, Sandhu D, Marwaha RK. Coprocessing of excipients: a review on excipient development for improved tableting performance. Int J Appl Pharm 2010;2:41-7.
35. Panda B, Raot A, Kilor V. Co-processed excipients: an overview of formulation aspects, physical characteristics, and role as a pharmaceutical aid. Pharmatutor Art 1049; 2010.
36. Limwong V, Sutanthavibul N, Kulvanich P. Spherical composite particles of rice starch and microcrystalline cellulose: a new co-processed excipient for direct compression. AAPS PharmSciTech 2004;5:40-9.
37. Gohel MC, Parikh RK, Brahmbhatt BK, Shah AR. Preparation and assessment of novel co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate: a technical note. AAPS PharmSciTech 2007;8:63-9.
38. Jacob S, Shirwaikar AA, Joseph A, Srinivasan KK. Novel coprocessed excipients of mannitol and microcrystalline cellulose for preparing fast dissolving tablets of glipizide. Indian J Pharm Sci 2007;69:633-9.
39. Barakat NS, Elbagory IM, Almurshedi AS. Controlled release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. Drug Delivery 2009;16:57-65.
40. Kumari MS, Prasanthi CH, Sudha Bhargavi CH, Kumari MP, Ushasri S. Reassessment of novel co-processed multifunctional excipients. IRJPAS 2013;3:122-8.
41. Gohel MC, Jogani PD. A review of co-processed directly compressible excipients. J Pharm Pharm Sci 2005;8:76-93.
42. Adeyeye MC. Roller compaction and milling pharmaceutical unit processes: Part I. Am Pharm Rev 2000;3:37–42.
43. Teng Y, Qiu ZH, Wen H. Systematical approach of formulation and process development using roller compaction. Eur J Pharm Biopharm 2009;73:219–29.
44. Bauer K, Kleeli K. Product based on polysaccharides co-processed with an insolubledisintegrant, process for its preparation and the use. EP1167433; 2002.
45. Bauer KH. Coprocessed polysaccharide product with insolublecarboxymethylcellulose. EP1070740, 2001.
46. Bauer K, Streb M. Coprocessed granules of disintegrating agents. EP1201709; 2002.
47. Hapgood KP, Tan MXL, Chow DWY. A method to predict nuclei size distributions for use in models of wet granulation. Adv Powder Technol 2009;20:293–7.
48. York FP, Rowe RC. Process control and scale-up of pharmaceutical wetgranulation processes: a review. Eur J Pharm Biopharm 2000;52:269–77.
49. Liu JP, Zhang F, McGinity JW. Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot melt extrusion. Eur J Pharm Biopharm 2001;52:181-90.
50. Bone A, Izebound E. Excipients on the move. IPEC Europe news. Available from: http://www.ipec-europe.org/UPLOADS/ 2004_October.pdf. [Last accessed on 15 Aug 2015]
51. Patel RP, Patel MP, Suthar AM. Spray drying technology: an overview. Indian J Sci Technol 2009;2:44-5.
52. Meggelaars MM, Biggelaar HA, Kussendrager, KD. Tabletingexcipient. US5534555, 1996.
53. Staniforth J. Pharmaceutical superdisintegrant. US20050100600; 2005.
54. Staniforth J. Pharmaceutical superdisintegrant. US6660303; 2003.
55. Rao VU, Balasubramaniam J, Haldar RK. Coprocessedexcipient compositions. US20120178822; 2012.
56. Gohel MC, Jogani PD. An investigation in direct compression characteristics of co-processed lactose-starch using an experimental design. Indian J Pharm Sci. 2003;65:31-8.
57. Cucula EJ, Luengo MG, Ortega AS. Modified calcium phosphateexcipient. US7364755; 2008.
58. Mehra DK, West KP, Wiggins DJ. Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation. EP0193984; 1986.
59. Lang S. Direct tableting auxillary US5006345; 1991.
60. Menon A, Gillece T, Chakrabarti S. Co-processing method for making a free-flowing compressible powder and tablet, US 5560927 A; 1996.
61. Sherwood BE, Hunter EA, Staniforth JH. Pharmaceutical excipient having improved compressibility. US5585115; 1996.
62. Ratnaraj S, Reilly Jr. WJ. Chewable pharmaceutical tablets. US5686107; 1997.
63. Bowe KE. Recent advances in sugar-based excipients. Pharma Sci Technol Today 1998;1:166–73.
64. Augello M, Vladyka RS, Dell SM. Taste masked pharmaceutical composition. US5904937; 1999.
65. Augello M, Reier GE. Microcrystalline cellulose/alginate wet granulation excipient/binder, US5985323; 1999.
66. Ibrahim N, Saraiya M. Co-processed botanical plant composition. US6232351; 2001.
67. Buliga GS, Tuason DC, Venables AC. Texture and stabilizer compositions. US6440474; 2002.
68. Cucula EJ, Luengo MG, Lana IM. Extended-release venlafaxine besylate tablets. US20060018963; 2006.
69. Norman GT, Nuguru KS, Amin AF, Chandar S. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms. US7118765; 2006.
70. Haldar R, Ray DB, Bee TG, Etienne S, Cheng S. Synergistic binder compositions, a method for making same, and tablets of an active and said binder having advantageous hardness and friability. US20070122472; 2007.
71. Li J, Carlin B, Ruszkay T. Co-processed microcrystalline and sugar alcohol as an excipient for tablet formulations. US20080131505; 2008.
72. Gandhi AS, Bagde P, Morvekar HN, Pilgaonkar PS, Rustomjee MT. Orally disintegrating tablets. US20090208576; 2009.
73. Nagendrakumar D, Raju SA, Shirsand SB, Para MS. Design of fast dissolving granisetron HCL tablets using novel co-processed superdisintegrants. J Biosci Technol 2009;1:8-14.
74. Ayyappan J, Umapathi P, Quine D. Development and evaluation of a directly compressible co-processed multifunction sustained release agent for tablets. Int J Pharm Pharm Sci 2010;2:201-5.
75. Dey NS, Panda BP, Rao MEB. Effect of co-processed direct compressible vehicles on fast dissolving tablets. Int J Phytother Res 2010;2:771-83.
76. Davar N, Kavalakatt P, Pather I, Ghosh S. Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same. US20100266682; 2010.
77. Adnan B, Iyad R, Mayyas ALR, Stephen AL, Babur ZC. A novel multifunctional pharmaceutical excipient: Modification of the permeability of starch by processing with magnesium silicate. Int J Pharm 2011;411:18-26.
78. Akram M, Naqvi SBS, Gauhar S. Development of co-processed micro granules for direct compression. IJPPS 2011;3:64-9.
79. Al Omari MM, Badwan AA, Daragmeh NH. Pharmaceutical excipient, a method for its preparation and use thereof. EP2384742; 2011.
80. Deorkar N, Farina J, Miinea L, Randive S. Directly compressible high functionality granular dibasic calcium phosphate-based co-processed excipient. US20110229527; 2011.
81. Olowosulu AK, Avosuahi O, Isah AB, Ibrahim MA. Formulation and evaluation of novel co-processed excipients of maize starch and acacia gum (StarAc) for direct compression tabletting. IJPRI 2011;2:39-45.
82. Thoorens G, Leclercq B, Ruszkay T. Microcrystalline celluloseand calcium phosphate compositions useful as pharmaceutical excipients. WO2011056775; 2011.
83. Gangurde AB, Amin PD. Formulation development and evaluation of metformin hydrochloride sustained release matrix tablet by using directly compressible co-processed excipient. World J Pharm Pharm Sci 2013;2:5296-308.
84. Pawar AY, Patil SH, Jadhav KR, Baviskar SR. Formulation and evaluation of matrix tablet of venlafaxine HCl by using directly compressible co-processed excipient. Int J Pharm Pharm Sci 2014;6:504-11.
85. Schmidt PC, Rubensdorfer CJ. Evaluation of ludipress as a multipurpose excipient for direct compression. Part 1. Powder characteristics and tableting properties. Drug Dev Ind Pharm 1994;20:2899-925.
86. Casalderrey M, Souto C, Concheiro A, Gomea Amoza JL, Martinez Pacheco R. A comparison of cellactose with TwoAd hoc processed lactose-cellulose blends as direct compression excipients. Chem Pharm Bull 2000;48:458-63.
87. Rizzuto AB, Chen AC, Veiga ME. Modification of the sucrose crystals structure to enhance pharmaceutical properties of excipient and drug substance. Pharm Tech 1984;8:32-9.
88. Bolhuis GK, Veen B, Wu YS, Zuuraman K, Frijlink HW. Compaction mechanism and tablet strength of unlubricated and lubricated silicified microcrystalline cellulose. Eur J Pharm Biopharm 2005;59:133-8.
89. Rojas J, Kumar V. Comparative evaluation of silicified microcrystalline cellulose as a direct compression vehicle. Int J Pharm 2011;416;120-8.
90. Uma Rani G, Begum N. Overview of co-processed excipients used to improve tabletting performance. J Adv Drug Delivery 2014;1:1-6.
91. Michoel A, Rombaut P. Comparative evaluation of co-processed lactose and microcrystalline cellulose with their physical mixtures in the formulation of folic acid tablets. Pharm Dev Technol 2002;7:79-87.
92. Bolhuis GK, Chowhan ZT. Materials for direct compression, pharmaceutical powder compaction technology, USA: Marcel Dekker; 1996;7:419-99.
93. Monedero Perales MC, Munoz Ruiz A, Velasco Antequera MV, Jimenez-Castellanos MR. Study of the compaction mechanisms of lactose-based direct compression excipients using indentation hardness and heckel plot. J Pharm Pharmacol 1994;46:177-81.
94. Soujanya B, Pavani PG, Murthy TEGK. Co-processing of excipients: A review on excipient development for improved tabletting performance. RJPDFT 2015;7:149-55.
95. Desai U, Chavan R, Mhatre P, Chinchole R. A review: co-processed excipients. Int J Pharm Sci Rev Res 2012;12:93-105.
96. Bolhuis GK, Zuurman K. Tableting proper¬ties of experimental and commercially available lactose granulations for direct compression. Drug Dev Ind Pharm 1995;21:2057-71.
97. Hauschild K, Picker KM. Evaluation of a new co-processed compound based on lactose and maize starch for tablet formulation. AAPS Pharm Sci 2004;6:1-12.
98. Muzikova J, Eimerova I. A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. Drug Dev Ind Pharm 2011;37:576-82.
99. Brniak W, Jachowicz R, Krupa A, Skorka T, Niwinski K. Evaluation of co-processed excipients used for direct compression of orally disintegrating tablets (ODT) using novel disintegration apparatus. Pharm Dev Technol 2013;18:464-74.
100. Schlack H, Bauer Brandl A, Schubert R, Becker D. Properties of fujicalin®, a new modified anhydrous dibasic calcium phosphate for direct compression: comparison with dicalcium phosphate dihydrate. Drug Dev Ind Pharm 2001;27:789-801.
101. Kanojia N, Kaur L, Nagpal M, Bala R. Modified excipients in novel drug delivery: the need of the day. IJTRM 2013;1:81–107.
102. Garg N, Dureja H, Kaushik D. Co-processed excipients: a patent review. Recent Pat Drug Delivery Formula 2013;7:73-83.
103. Kumare MM, Marathe RP, Kawade RM, Ghante MH, Shendarkar GR. Design of fast dissolving tablet of atenolol using novel co-processed. Asian J Pharm Clin Res 2013;6:81-5.
104. Parfati N, Rani KC, Meilany M. The effect of coprocessed superdisintegrants ratio (crospovidone-sodium starch glycolate) to the physicochemical characteristics of atenolol orally disintegrating tablets. Asian J Pharm Clin Res 2018;11:318-24.
105. Parfati N, Rani KC, Charles N, Geovany V. Preparation and evaluation of atenolol-β-cyclodextrin orally disintegrating tablets using co-process crospovidone-sodium starch glycolate. Int J Appl Pharm 2018;10:190-4.
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How to Cite
Bin, L., A. Gaurav, and U. Mandal. “A REVIEW ON CO-PROCESSED EXCIPIENTS: CURRENT AND FUTURE TREND OF EXCIPIENT TECHNOLOGY”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 1, Jan. 2019, pp. 1-9, doi:10.22159/ijpps.2019v11i1.29265.
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