DERIVATIVE UV SPECTROSCOPIC APPROACHES IN MULTICOMPONENT ANALYSIS–A REVIEW

  • Gummadi Sowjanya Department of Pharmaceutical Analysis, Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India
  • GANAPATY S. Department of Pharmaceutical Analysis, Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India
  • SARA ALMAS Department of Pharmaceutical Analysis, Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India

Abstract

The spectrophotometric multi-component analysis involves spectrum recording and mathematical equations. However, spectral interference poses a major limitation when mixture samples are encountered. To overcome this derivative spectrophotometry (DS) has been introduced for the resolution of overlapping peaks.


In this review modified methods like derivative quotient spectra, double divisor ratio spectra derivative method, double divisor means centering of ratio spectra method, derivative subtraction coupled with the constant multiplication method (DS-CM), amplitude subtraction (AS), modified amplitude subtraction (MAS), amplitude factor method (P-Factor), amplitude modulation method (AM), amplitude summation method (A-Sum), simultaneous derivative ratio spectrophotometry (S1DD), derivative compensation ratio via regression equation, differential dual wavelength (D1 DWL), differential derivative ratio (D1DR), successive derivative subtraction method (SDS) and derivative transformation (DT) of derivative spectrophotometry theories and applications are reviewed.


These methods were applied to solve different complex pharmaceuticals mixtures. These developed methods were simple and cost-effective.

Keywords: Multicomponent analysis, Derivative spectrophotometry, Overlapping peaks, Derivative quotient spectra, Derivative subtraction, Simultaneous derivative ratio spectrophotometry, Derivative transformation, Complex pharmaceutical mixtures

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Author Biography

Gummadi Sowjanya, Department of Pharmaceutical Analysis, Institute of Pharmacy, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India

Assistant Professor,

GITAM Institute of Pharmacy

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How to Cite
Sowjanya, G., G. S., and S. ALMAS. “DERIVATIVE UV SPECTROSCOPIC APPROACHES IN MULTICOMPONENT ANALYSIS–A REVIEW”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 2, Dec. 2018, pp. 1-11, doi:10.22159/ijpps.2019v11i2.30510.
Section
Review Article(s)