THE BENEFICIAL EFFECT OF 20% SUNFLOWER SEED OIL CREAM ON MILD ATOPIC DERMATITIS IN CHILDREN

  • Reiva Farah Dwiyana Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Hartati Purbo Darmadji Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Risa Miliawati Nurul Hidayah Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Fitra Hergyana Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Srie Prihiantini Gondokaryono Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Inne Arline Diana Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Catherina Jessica Sutantoyo Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia
  • Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Pasteur 38, Bandung, West Java 40161, Indonesia

Abstract

Objective: The objective of this study was to evaluate the beneficial effect of topical applications of 20% sunflower seed oil (SSO) in decreasing the transepidermal water loss (TEWL) and scoring of atopic dermatitis (SCORAD) index value in mild atopic dermatitis (AD) pediatric patients in Bandung, Indonesia.


Methods: This was a randomized study involving 20 children with mild AD (SCORAD<25) in Bandung, Indonesia. They were divided into 2 groups: the experimental group treated with 20% SSO cream and the control group treated with a common moisturizing cream for four weeks. The TEWL score including SCORAD index was evaluated at baseline, week 1, week 2, and week 4.


Results: A total of 20 participants completed the study. In the first week, the control group had TEWL score decrement by 36.62% while the experimental group by 28.89% (p=0.88). In the fourth week, the TEWL decrements of the experimental and control group were by 56.94% and 52.50%, respectively (p=0.20), and this was followed by an improvement of SCORAD index in both treatment groups.


Conclusion: The 20% SSO cream has a beneficial effect in decreasing the TEWL score and improving SCORAD indices. Therefore, it can be considered as an alternative treatment for mild AD among children.

Keywords: Atopic dermatitis, Moisturizer, Sunflower seed oil, Transepidermal water loss

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Dwiyana, R. F., H. P. Darmadji, R. M. N. Hidayah, F. Hergyana, S. P. Gondokaryono, I. A. Diana, C. J. Sutantoyo, and H. Gunawan. “THE BENEFICIAL EFFECT OF 20% SUNFLOWER SEED OIL CREAM ON MILD ATOPIC DERMATITIS IN CHILDREN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 11, no. 2, Jan. 2019, pp. 100-3, doi:10.22159/ijpps.2019v11i2.30707.
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