PRO-INFLAMMATORY CYTOKINES ELICIT INFLAMMATORY RESPONSE IN BLOOD LEUKOCYTES OF POST DIALYTIC CHRONIC RENAL PATIENTS THROUGH HEME OXYGENASE-1 ACTIVATION

  • Sathyapriya Kandavelu Post-Graduate Department of Biochemistry, Bharathi Women’s College, Chennai 600108
  • Parameswari Chetenchery Somasundaram Post-Graduate Department of Biochemistry, Bharathi Women’s College, Chennai 600108
  • Binuclara John Department of Biochemistry, University of Madras, Chennai 600025
  • Ravikumar Rajendran Department of Biochemistry, University of Madras, Chennai 600025

Abstract

Objective: Inflammation is common in patients with chronic renal failure and has beenassociated with the increased production of pro-inflammatory cytokines. Theaim of the investigation is to assess the levels of the pro-inflammatory cytokines,TGF-β,IL-1βand TNF-α and correlate it with HO-1 expression in the leukocytes of renal failurepatients.
Methods: Cytokine profile was analyzed in53South Indianpatients suffering from ESRD under post dialysis condition (2 hrs after dialysis).
Results: Augmented production of TGF-β,IL-1βand TNF-α was observed in the peripheral bloodleukocytes of the patient population.Anincrease in the expression of HO-1 in the leukocytes was demonstrated from our earlier studies.
Conclusion: Thus,our study hypothesized that the inflammatory reaction in the leukocytes of the post dialytic renalfailure cases might be due to the elevation in HO-1 levels brought about by altered pro-inflammatory cytokine levels

Keywords: Pro-inflammatory cytokines, HO-1, Dialysis, Leukocytes, Renal failure, Blood.

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Kandavelu, S., P. C. Somasundaram, B. John, and R. Rajendran. “PRO-INFLAMMATORY CYTOKINES ELICIT INFLAMMATORY RESPONSE IN BLOOD LEUKOCYTES OF POST DIALYTIC CHRONIC RENAL PATIENTS THROUGH HEME OXYGENASE-1 ACTIVATION”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 9, 1, pp. 111-5, https://innovareacademics.in/journals/index.php/ijpps/article/view/3213.
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