PRO-INFLAMMATORY CYTOKINES ELICIT INFLAMMATORY RESPONSE IN BLOOD LEUKOCYTES OF POST DIALYTIC CHRONIC RENAL PATIENTS THROUGH HEME OXYGENASE-1 ACTIVATION
Objective: Inflammation is common in patients with chronic renal failure and has been associated with the increased production of pro-inflammatory cytokines. The aim of the investigation is to assess the levels of the pro-inflammatory cytokines, TGF- Î², ILâ€1Î² and TNFâ€Î± and correlate it with HO-1 expression in the leukocytes of renal failure patients.
Methods: Cytokine profile was analyzed in 53 South Indian patients suffering from ESRD under post dialysis condition (2 hrs after dialysis). Augmented production of TGF- Î², ILâ€1Î² and TNFâ€Î± was observed in the peripheral blood leukocytes of the patient population.
Results: An increase in the expression of HO-1 in the leukocytes was demonstrated from our earlier studies.
Conclusion: our study hypothesized that the inflammatory reaction in the leukocytes of the post dialytic renal failure cases might be due to the elevation in HO-1 levels brought about by altered pro-inflammatory cytokine levels.
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