DIURETIC EFFECT OF THE ETHANOL EXTRACTS OF PHYLLANTHUS ACIDUS L (SKEELS) LEAVES IN WISTAR RATS


Suci Nar Vikasari, Elin Yulinah Sukandar, Afifah Bambang Sutjiatmo, Soraya Riyanti

Abstract


Objective: The objective of this study is to test diuretic effect of ethanol extract of P. acidus leaves in female Wistar rats using modification of Lipschitz method.

Methods: The doses of the extract were 22.5, 45 and 90 mg/kg bw. Parameter of diuretic effect was cumulative urine volume during 6 and 24 hours after administration of the extract. Sodium and potassium level in urine were analyzed using atomic absorption spectrophotometry (AAS). The results were analyzed with Student-t test.

Results: The ethanol extracts of P. acidus at doses of 22.5, 45, and 90 mg/kg bw could accelerate the urinary in rats since 60 minutes after oral administration compared to the control and furosemide 3.6 mg/kg bw (P<0.05). The level of sodium on 24 hour urine of the ethanol extracts of P. acidus at doses 22.5 and 45 mg/kg bw significantly higher than control group (P<0.05), but significantly lower than furosemide 3.6 mg/kg bw (P<0.05). The level of potassium on 24 hour urine of the ethanol extracts of P. acidus at doses 45 and 90 mg/kg bw significantly higher than control group (P<0.05), but significantly lower than furosemide 3.6 mg/kg bw (P<0.05).

Conclusion: It can be concluded that the ethanol extract of P. acidus at doses of 22.5 mg/kg bw, 45 mg/kg bw and 90 mg/kg bw had significantly diuretic and saluretic effect compared to control group (P<0.05), but significantly less than furosemid 3.6 mg/kg bw (P<0.05).


Keywords


Phyllanthus acidus, Ceremai, Diuretic, Saluretic, Sodium, Potassium.

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About this article

Title

DIURETIC EFFECT OF THE ETHANOL EXTRACTS OF PHYLLANTHUS ACIDUS L (SKEELS) LEAVES IN WISTAR RATS

Keywords

Phyllanthus acidus, Ceremai, Diuretic, Saluretic, Sodium, Potassium.

Date

11-11-2014

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 1, 2015 Page: 120-123

Online ISSN

0975-1491

Statistics

390 Views | 50 Downloads

Authors & Affiliations

Suci Nar Vikasari
Department of Pharmacy, University of General Achmad Yani, Cimahi, Indonesia Center of Life Sciences, Institut Teknologi Bandung, Bandung, Indonesia
Indonesia

Elin Yulinah Sukandar
School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia

Afifah Bambang Sutjiatmo
Department of Pharmacy, University of General Achmad Yani, Cimahi, Indonesia Center of Life Sciences, Institut Teknologi Bandung, Bandung, Indonesia

Soraya Riyanti
Department of Pharmacy, University of General Achmad Yani, Cimahi, Indonesia


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