• Oleg Shpychak Doctor of Pharmacy, Professor


Objective: The purpose of the research is to optimize a technology for producing a magneto controllable nanocomposite Ag@Fe3O4, which meets modern physicochemical and therapeutic requirements using methods of mathematical design of the experiment.

Methods: Synthesis of Ag@Fe3O4 samples: Fe (II) and Fe (III) salt solutions have been mixed, an ammonia solution has been introduced, and then a reducing agent and silver nitrate have been added.

To optimize the synthesis process, the method of factor experiment has been used. Mathematical calculations have been performed using the STATISTICA 10 StatSoft Inc. system and Excel spreadsheet processor of MS Office 2019 Professional Plus.

Results: 16 samples of the nanocomposite Ag@Fe3O4 with a molar ratio of Fe3O4 : Ag 1: 0.5 have been obtained; the main characteristics of which (the average nanoparticle size was ~30 nm, the silver was located on the surface is in the form of islands, the thickness of the silver layer was 0.5 – 2 nm, the area of silver islands was ~40% of the total surface area of the particles) have been established by modern physicochemical methods.

As a result of calculations, we have obtained a regression equation of the synthesis process Ag@Fe3O4: Y = 106.415 + 0.038X1 + 4.448Х2 + 1.806Х3 – 1.593Х4 – 18.945Х5 – 109.980Х6. By the use of this equation we have optimized the synthesis parameters with a help of steepest ascent method.

Conclusions: A rational one-pot synthesis method has been developed, which makes possible to obtain Ag@Fe3O4 with a certain particle size, on the surface of which silver clusters are in the form of islands, while the magnetic controlled properties of the target product are completely preserved.

Using mathematical design of the experiment, a technology has been developed for producing Ag@Fe3O4, which meets modern physicochemical and therapeutic requirements.

It has been found that the maximum yield of Ag@Fe3O4 can be achieved under the following conditions: X1 (magnetite synthesis time, min) – 40; X2 (glucose content in solution,%) – 10; X3 (temperature of the Tollens reaction, °С) – 65; X4 (magnetite silver coating time, min) – 30; X5 (pH, units) – 8.5; X6 (rate of addition of ammonia, mol/min) – 0.36.

Keywords: synthesis, technology, nanoparticles, silver shell, magneto controllable composite system, methods of mathematical design, regression and correlation analysis, response surface methodology.


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How to Cite
Shpychak, O. “OPTIMIZATION OF THE TECHNOLOGY FOR PRODUCING A MAGNETO CONTROLLABLE NANOCOMPOSITE USING MATHEMATICAL DESIGN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 1, Nov. 2019, https://innovareacademics.in/journals/index.php/ijpps/article/view/35870.
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