OPTIMIZATION OF THE TECHNOLOGY FOR PRODUCING A MAGNETO CONTROLLABLE NANOCOMPOSITE Ag@Fe3O4 USING MATHEMATICAL DESIGN

  • ОLEG S. KRYSKIV National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • TETYANA M. CHAN National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • ALLA O. KOVAL National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • OLEG S. SHPYCHAK National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • KATERYNA P. ROMAS National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • OLEKSANDRA S. KRAN National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • TETIANA V. MARTYNIUK National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002
  • OLGA V. ANTONENKO National University of Pharmacy, 53, Pushkinska St., Kharkiv, Ukraine, 61002

Abstract

Objective: The purpose of the research was to optimize technology for producing a magneto controllable nanocomposite Ag@Fe3O4 with modern physicochemical and therapeutic requirements using methods of mathematical design of the experiment.


Methods: To optimize the synthesis process of the nanocomposite Ag@Fe3O4, the method of factor experiment was used. Mathematical calculations were performed using the STATISTICA 10 StatSoft Inc. system and Excel spreadsheet processor of MS Office 2019 Professional Plus.


Results: Based on the study of technological parameters of nanocomposite synthesis Ag@Fe3O4 (16 experiments) a regression equation was obtained: Y = 106.415+0.038X1+4.448Х2+1.806Х3–1.593Х4–18.945Х5–109.980Х6. By the use of this equation the synthesis parameters were optimized with the help of steepest ascent method. It was found that the maximum yield of Ag@Fe3O4 can be achieved under the following conditions: X1 (magnetite synthesis time, min)–40; X2 (glucose content in solution,%)–10; X3 (temperature of the Tollens reaction, °С)–65; X4 (magnetite silver coating time, min)–30; X5 (pH, units)–8.5; X6 (rate of addition of ammonia, mol/min)–0.36.


Conclusion: Using mathematical design of the experiment, a technology was developed for producing Ag@Fe3O4 with modern physicochemical and therapeutic requirements.

Keywords: Synthesis, Technology, Nanoparticles, Silver shell, Magneto controllable composite system, Methods of mathematical design, Regression and correlation analysis, Response surface methodology

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KRYSKIVО. S., T. M. CHAN, A. O. KOVAL, O. S. SHPYCHAK, K. P. ROMAS, O. S. KRAN, T. V. MARTYNIUK, and O. V. ANTONENKO. “OPTIMIZATION OF THE TECHNOLOGY FOR PRODUCING A MAGNETO CONTROLLABLE NANOCOMPOSITE Ag@Fe3O4 USING MATHEMATICAL DESIGN”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 1, Nov. 2019, pp. 26-30, doi:10.22159/ijpps.2020v12i1.35870.
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