ANALYSIS OF VIPAKA (METABOLIC TRANSFORMATION) OF AN EXTRA-PHARMACOPOEIAL DRUG-BRIDELIA STIPULARIS (L.) BLUME

  • HARITHA N Department of Dravyagunavijnana, V. P. S. V. Ayurveda College, Kottakkal, Kerala
  • SUDHAKAR BHAT Department of Pharmacology, SDM Centre for Ayurveda and Allied Sciences, Udupi, Karnataka
  • N MANOJ KUMAR Department of Dravyagunavijnana, V. P. S. V. Ayurveda College, Kottakkal, Kerala

Abstract

Objective: The objective of the present study is to explore the vipaka of an extra-pharmacopoeia drug Bridelia stipularis (L.) Blume belongs to the Euphorbiaceae family.


Methods: 12 Wistar strain albino rats were selected and divided into 2 groups; Group A-Control, Group B-Test group. Each rat was kept in separate metabolic cages provided with a constant amount of water and food per day. Assessment of vipaka was done based on the consumption of food, consumption of water, the quantity of faecal matter, urine output, and quantity of water content of expelled faecal matter per day. Assessment of Vipaka was done on the basis of consumption of food; consumption of water; the quantity of faecal matter, urine output and quantity water content of expelled faecal matter per day. Assessment of Vipaka was done on the basis of consumption of food; consumption of water; the quantity of faecal matter, urine output and quantity water content of expelled faecal matter per day.


Results: Absolute values of Group B or test group exhibited significant increase in water consumption (p<0.01), wet faecal matter (p<0.05), dry faecal matter (p<0.001), and food conversion ratio (p<0.05), and non-significant increase in food consumption, urine output, faecal water, and body weight.


Conclusion: Based on the preliminary analysis it may be concluded that the drug Bridelia stipularis (L.) Blume possess Madhura vipaka (Sweet metabolic transformation).

Keywords: Bridelia stipularis, Vipaka, Vipaka assessment

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N, H., S. BHAT, and N. M. KUMAR. “ANALYSIS OF VIPAKA (METABOLIC TRANSFORMATION) OF AN EXTRA-PHARMACOPOEIAL DRUG-BRIDELIA STIPULARIS (L.) BLUME”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 3, Jan. 2020, pp. 23-27, doi:10.22159/ijpps.2020v12i3.36030.
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