ANALYSIS OF VIPAKA (METABOLIC TRANSFORMATION) OF AN EXTRA-PHARMACOPOEIAL DRUG-BRIDELIA STIPULARIS (L.) BLUME
Objective: The objective of the present study is to explore the vipaka of an extra-pharmacopoeia drug Bridelia stipularis (L.) Blume belongs to the Euphorbiaceae family.
Methods: 12 Wistar strain albino rats were selected and divided into 2 groups; Group A-Control, Group B-Test group. Each rat was kept in separate metabolic cages provided with a constant amount of water and food per day. Assessment of vipaka was done based on the consumption of food, consumption of water, the quantity of faecal matter, urine output, and quantity of water content of expelled faecal matter per day. Assessment of Vipaka was done on the basis of consumption of food; consumption of water; the quantity of faecal matter, urine output and quantity water content of expelled faecal matter per day. Assessment of Vipaka was done on the basis of consumption of food; consumption of water; the quantity of faecal matter, urine output and quantity water content of expelled faecal matter per day.
Results: Absolute values of Group B or test group exhibited significant increase in water consumption (p<0.01), wet faecal matter (p<0.05), dry faecal matter (p<0.001), and food conversion ratio (p<0.05), and non-significant increase in food consumption, urine output, faecal water, and body weight.
Conclusion: Based on the preliminary analysis it may be concluded that the drug Bridelia stipularis (L.) Blume possess Madhura vipaka (Sweet metabolic transformation).
2. Bhandary MJ, Chandrashekar KR. Herbal therapy for herpes in the ethnomedicine of coastal Karnataka. Indian J Traditional Knowledge 2011;10:528-32.
3. Oratai N, Patcharin S, Kornkanok Y, Narumon S. A survey of medicinal plants in mangrove and beach forests from peninsula, songkhla province, Thailand. J Med Plant Res 2012;6:2421-37.
4. Vagbhata Laghu. Ashtanga Hridaya. (Sarvangasundara commentary of arunadatta). Pt. Harisadasiva Sastri Paradakara. editor. Varanasi: Chaukhamba Sanskrit Samsthan; Reprint; 2011. p. 169.
5. Dhyani SC. Rasa-pancaka ayurvrdic principle of drug action. 2nd ed. Varanasi, India: Chaukhamba Krishnadas Academi Publisher; 2003. p. 76-80.
6. Bidhan Mahajon, Ravi Shankar B, Remadevi R. Assessment ‘vipaka’(metabolism) of a new medicinal plant in an animal model. Global J Res Med Plants Indigen Med 2014;11:434.
7. Atreyabhadrakapiyamadhyaya: Vaidya Jadavaji Trikamji. Charaka Samhita: Sootrasthana. Varanasi: Chowkhambha Sanskrit Series; 2014. p. 146.
8. Dravyadi Vijnaniya Adhyaya, KR Sreekantha Moorthy. Ashtanga sangraha of vagbhata: sootrasthana. 8th ed. Varanasi: Chaukhamba Orientalia; 2004. p. 326.
This work is licensed under a Creative Commons Attribution 4.0 International License.