COMBINATION OF MOMORDICA CHARANTIA AND PHYLLANTHUS AMARUS FOR HEPATOPROTECTIVE ACTIVITY IN ETHANOL AND ANTI-TUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN RATS

  • PURNIMA ASHOK Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India
  • LAVANYA P. Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India
  • HEMANTH K. Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India
  • SANDESH K. M. Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India
  • YUVRAJ SINGH SURANA Department of Pharmacology, KLE College of Pharmacy, Bengaluru, Karnataka, India

Abstract

Objective: To evaluate the synergistic protective effect of Momordica charantia and Phyllanthus amarus combination (MC+PA) of doses 200 and 400 mg/kg on the liver in different experimental models of hepatotoxicity.


Methods: The hepatoprotective activity was evaluated in ethanol and anti-tubercular drugs (isoniazid-INH, rifampicin-RIF) induced hepatotoxicity models. Hepatotoxicity in both models was induced to all groups except the normal control. Intoxicated rats were treated with silymarin and various doses of MC+PA for 8 d in ethanol-induced and 21 d in INH+RIF induced hepatotoxicity models. At the completion of study, the biochemical markers and the anti-oxidant status (SOD and MDA) were measured and also the histopathological evaluation of the liver tissue was carried out.


Results: Combination therapy remarkably reduced the elevated profile of the biochemical markers and thereby improved the anti-oxidant status, thus exhibiting the synergistic hepatoprotective effect when compared with the positive control group (p<0.001). Histopathological evaluation demonstrated that MC+PA decreased the liver damage significantly in comparison with the positive group.


Conclusion: The current work suggests that the combined extract showed synergistic effects on ethanol and anti-tubercular drugs induced hepatotoxicity models by significantly decreasing the liver damage.

Keywords: Hepatoprotective, Hepatotoxicity, Ethanol, INH RIF, MC PA

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ASHOK, P., L. P., H. K., S. K. M., and Y. S. SURANA. “COMBINATION OF MOMORDICA CHARANTIA AND PHYLLANTHUS AMARUS FOR HEPATOPROTECTIVE ACTIVITY IN ETHANOL AND ANTI-TUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 8, June 2020, pp. 166-71, doi:10.22159/ijpps.2020v12i8.38020.
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