• Dr. Nidhi P. Sapkal
  • Nidhi Jaiswal


Objective:- To synthesize & evaluate taste-masked ionic liquid (IL) salts of loratadine.

Methods:-In present work pharmaceutically activeIL saltsof loratadine using selected counter-ions were synthesized.  The synthesized IL salts were characterized using melting point, Ultraviolet (UV) Spectroscopy, Fourier Transform Infra-Red (FTIR) Spectroscopy, Differential Scanning Calorimetry (DSC) & X-ray Diffraction (XRD). These salts were also evaluated for solubility, dissolution and palatability studies.

Result:- All synthesized  IL salts of loratadine exhibited melting points below 100 °C.  UV spectral data and FTIR data confirmed formation of new salt forms with selected counter-ions. Absence of sharp melting point peaks during DSC studies revealed amorphous nature of new salt forms. During XRD studies, loratadine-indomethacin salt yield completely amorphous compound while other counter-ions intensity of the characteristic peaks of loratadine was found to be reduced. Solubility studies revealed decreased solubility of  IL salts in water as compared to loratadine due to lipophilic nature of counter-ions i.e., from 35.85 mg/ml to 3.63 mg/ml, 15.39 mg/ml, 5.31 mg/ml & 3.71 mg/ml respectively. Dissolution studies further confirmed it by showing % drug release from 0.5% reduced to in range from 0.5 to 0.1% in 75 minutes considerably. Except for oleate, all of IL salts were found to be palatable by volunteers in range of 2.5 to 2.8 which is standard range for palatability.

Conclusion:- Results obtained in present work indicated that  IL salts of loratadine were synthesized successfully using selected counter-ions. They have better taste than pure loratadine & hence can be used in drug products intended for children.

Keywords: IL salts, Loratadine, counter-ions, taste masking.


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How to Cite
GONDANE, P., N. Sapkal, and N. Jaiswal. “SYNTHESIS AND EVALUATION OF TASTE-MASKED IONIC LIQUID SALTS OF LORATADINE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 11, Sept. 2020,
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