ANTICATARACT POTENTIAL OF BARLERIA PRIONITIS: IN VIVO STUDY

  • Mohammed Atif SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY
  • Shaik Abdul Rahman SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY
  • Mohammed Ibrahim Ahmed SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY
  • Syed Baquer Mahmood SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY
  • Mohammed Azharuddin SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY

Abstract

Objective: The present study was formulated in order to evaluate the Anticataract potential of Barleria prionitis using Selenite and Galactose induced cataract models.

Methods: Barleria prionitis (Family-Acanthaceae), used in mythical system possessing antioxidant activity was evaluated for its Anticataract potential. The ability of Barleria prionitis to tweak the biochemical parameters was explored in these studies. Selenite cataract was incited in 10 days old pups by subcutaneous infusion of sodium Selenite (25 moles/kg of body weight). The rats in the test gathering were infused with Barleria prionitis (200 and 400 mg/kg body weight, p. o.) 4 h before the Selenite administration. The rate of cataract was watched when the rats initially opened their eyes on 16th day. Galactose cataract was actuated in rats by sustaining 30% Galactose in the eating regimen. Rats in the test gathering were sustained orally with 200 and 400 mg/kg of Barleria prionitis every day and rats in the control gathering got just vehicle. Cataract stages were evaluated at normal interims.

Results: In this study, morphological assessment demonstrated that Selenite treated gathering demonstrates increased opacities when contrasted with normal gathering. A fall in the glutathione level and a climb in the Malondialdehyde levels were seen in control rather than normal lenses. Administration of Barleria prionitis significantly restored the glutathione and Malondialdehyde levels. SOD, Catalase and Glutathione S transferase levels were significantly restored to normal levels (p<0.05 and p<0.01 respectively). Oral administration of Barleria prionitis significantly delayed the onset and progression of cataract in Selenite as well as Galactose induced cataract.

Conclusion: The Anticataract potential is evident from the slit lamp microscopic images. It can be said that Barleria prionitis significantly reversed the cataract parameters by virtue of its antioxidant potential, which may be useful for further molecular studies to determine the exact mechanism for its Anticataract potential.

 

Keywords: Barleria prionitis, Oxidative Stress, Antioxidant, Vitamin E

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Author Biography

Mohammed Atif, SHADAN COLLEGE OF PHARMACY, DEPARTMENT OF PHARMACOLOGY
DEPARTMENT OF PHARMACOLOGY, STUDENT

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How to Cite
Atif, M., S. A. Rahman, M. I. Ahmed, S. B. Mahmood, and M. Azharuddin. “ANTICATARACT POTENTIAL OF BARLERIA PRIONITIS: IN VIVO STUDY”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 2, Dec. 2014, pp. 100-5, https://innovareacademics.in/journals/index.php/ijpps/article/view/3908.
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