DRUG UTILIZATION EVALUATION OF ANGIOTENSIN RECEPTOR BLOCKER (ARB) ALONG WITH THEIR ADRS IN A TERTIARY CARE HOSPITAL
Objective: To evaluate the drug utilization of Angiotensin Receptor Blocker (ARB) along with their ADRs in a tertiary care hospital. And to monitor, report of adverse drug reaction and drug interactions, if any.
Methods: The patients who meet the inclusion and exclusion criteria were enrolled into the study. The pertinent data such as demographic details, drug name, dose, frequency, and laboratory data were gathered from medical records of the patient and results were analyzed.
Results: Total of 100 patients were included in this study, the maximum utilization of antihypertensive drug (ARB) was telmisartan (90%) and widely use of ARBs in the age group of 41-50 y. Total 32 ADRs were observed and most probable ADRs included headache (42.8%), Nausea (14.28%) and dizziness (12.5%).
Conclusion: Telmisartan was the most prescribed and utilized drug than the other drugs of ARBs. Maximum ADRs were noted in females, the most frequent ADRs headache, nausea and dizziness were reported. The majority of reactions were probable on causality assessment done by WHO-UMC and Naranjo’s scale having mild severity. So it can be concluded that considering risk factors, prevention and management of ADRs can drastically improve the therapeutic outcomes of the patients.
2. Egan Brent M, Kjeldsen Sverre E, Grassi Guidoc, Esler Murray, Mancia Guiseppe. The global burden of hypertension exceeds 1.4 billion people. J Hypertens 2019;37:1148-53.
3. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217–23.
4. Saeed AA, Al-Hamdan NA, Bahnassy AA, Abdalla AM, Abbas MA, Abuzaid LZ. Prevalence, awareness, treatment, and control of hypertension among Saudi adult population: a national survey. Int J Hypertens 2011;2011:174135.
5. Lawes CM, Vander Hoorn S, Rodgers A. Global burden of blood-pressure related disease, 2001. Lancet 2008;37:1513–8.
6. Al-Hamdan N, Saeed A, Kutbi A, Choudhry A, Nooh R. Characteristics, risk factors, and treatment practices of known adult hypertensive patients in Saudi Arabia. Int J Hypertens 2011;168739. DOI:10.4061/2010/168739.
7. Al-Nozha MM, Abdullah M, Arafah MR, Khalil MZ, Khan NB, Al-Mazrou YY, et al. Hypertension in Saudi Arabia. Saudi Med J 2007;28:77-84.
8. Ahmed AM, Hersi A, Mashhoud W, Arafah MR, Abreu PC, Al Rowaily MA, et al. Cardiovascular risk factors burden in Saudi Arabia: the Africa Middle East cardiovascular epidemiological (ACE) study. Saudi Heart Assoc 2017;29:235–43.
9. Rimoy GH, Justin Temu M, Nilay C. Prescribing patterns and cost of antihypertensive drugs in private hospitals in dar es Salaam. East Cent Afr J Pharm Sci 2008;11:69?73.
10. Gu Q, Paulose Ram R, Dillon C, Burt V. Antihypertensive medication use among
11. US adults with hypertension. Circulation 2006;113:213–21.
12. European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003;21:1011-53.
13. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003;42:1206–52.
14. Liu PH, Wang JD. Antihypertensive medication prescription patterns and time trends for newly diagnosed uncomplicated hypertension patients in Taiwan. BMC Health Serv Res 2008;8:133.
15. Guo JD, Liu GG, Christensen DB, Fu AZ. How well have practices followed guidelines in prescribing antihypertensive drugs: the role of health insurance. Value Health 2003;6:18-28.
16. Najla A Alshehri, Turky H Almigbal, Abdulaziz Alodhayani, Mohammed Ali Batais. Family and internal medicine resident’s awareness of and adherence to the Joint National Committee 8 (JNC 8) hypertension guidelines: a crosssectional study. Biomed Res 2017;28:5572-9.
17. Rachana PR, Anuradha HV, Shivamurthy M. Antihypertensive prescribing patterns and cost analysis for primary hypertension: a retrospective study. J Clin Diagn Res 2014;8:19?22.
18. Ali, Mohammad. Cost analysis and utilization of antihypertensive drug therapy in Saudi Arabia. J Pharm Health Services Res 2020. https://doi.org/10.1111/jphs.12372
19. Akhtar AK, Divya V, Pillai KK, Kiran D. Drug prescribing practices in pediatric department of a North Indian University Teaching Hospital. Asian J Pharm Clin Res 2012;5:146?9.
20. Essential Medicines and Health Products Information Portal, World Health Organization. Available From: http:// apps.who.int/medicinedocs/en/d/Js4882e/8.5.html [Last accessed on 19 Jul 2020].
21. Regitz Zagrosek V. Sex and gender differences in health-science and society series on sex and science. Eur Mol Biol Organization Repots 2012;7:596-603.
22. Ansari MS, F Al-otaibi. “Drug utilization based adrs monitoring of antihypertensive agents prescribed in al-quwayiyah general hospital, saudi arabia”. Int J Pharm Pharm Sci 2018;10:22-6.
23. Amy Barreras, Cheryle Gurk Turner. Angiotensin II receptor blockers. Proc (Bayl Univ Med Cent) 2003;16:123–6.
This work is licensed under a Creative Commons Attribution 4.0 International License.