DRUG UTILIZATION EVALUATION OF ANGIOTENSIN RECEPTOR BLOCKER (ARB) ALONG WITH THEIR ADRS IN A TERTIARY CARE HOSPITAL

DRUG UTILIZATION EVALUATION OF ANGIOTENSIN RECEPTOR BLOCKER (ARB) ALONG WITH THEIR ADRS IN A TERTIARY CARE HOSPITAL

  • RIYASAT RIYASAT College of Pharmacy, Teerthanker Mahaveer University
  • MD. SHAMIM
  • JIGAR HARIA
  • MOHAMMAD DAUD ALI
  • MD. SARFARAZ ALAM
  • MD. SARFARAZ AHMAD

Abstract

Objective: To evaluate the drug utilization of Angiotensin Receptor Blocker (ARB) along with their ADRs in a tertiary care Hospital. And to monitor, report of adverse drug reaction and drug interactions, if any.


Methods: The patients who meet the inclusion & exclusion criteria were enrolled into the study. The relevant data such as demographic details, drug name, dose, frequency, and laboratory data were collected from medical records of the patient and results were analyzed.


Result: A total of 100 patients were included in this study, the maximum utilization of antihypertensive drug (ARB) was telmisartan (90%) and widely use of ARBs in the age group of 41-50 years. A total 32 ADRs were observed and most probable ADRs included headache (42.8%), nausea (14.28%) and dizziness (12.5%).


Conclusion: Telmisartan was the most prescribed and utilized drug than the other drugs of ARBs. A total 100 patients were included in this study and enrolled in which the most therapy was dual therapy (41%) followed by single or monotherapy (38%), triple (18%) and tetra therapy (3%) of ARBs (telmisartan, olmesartan & azilsartan) with or without other class of antihypertensive drugs (Diuretics, CCBs, beta blockers and other). Maximum of ADRs were found in females and in the age group of 41-50 years of the total population of 32 patients, the most common ADRs headache, nausea and dizziness were reported. The majority of reactions were probable on causality assessment done by WHO-UMC and Naranjo’s scale having mild severity. So it can be concluded that considering risk factors, prevention and management of ADRs can significantly improve the therapeutic outcomes of the patients.

Keywords: Antihypertensive drugs, Angiotensin Receptor Blockers (ARBs), ADRs, Drug utilization, Telmisartan, Olmesartan, Azilsartan.

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Author Biographies

RIYASAT RIYASAT, College of Pharmacy, Teerthanker Mahaveer University

Department of Pharmacy Practice, College of Pharmacy, Teerthanker Mahaveer University. Delhi Road, NH 24, Bagadpur, Uttar Pradesh 244001, India.

MD. SHAMIM

1.     Department of Pharmacy Practice, College of Pharmacy, Teerthanker Mahaveer University. Delhi Road, NH 24, Bagadpur, Uttar Pradesh 244001, India.

2.     Department of Pharmacy, Lakhmi Chand Patwari pharmacy college, Baghpat. SH 57, Khekra, Uttar Pradesh, 250101, India.

JIGAR HARIA

Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University. Delhi Road, NH 24, Bagadpur, Uttar Pradesh 244001, India.

MOHAMMAD DAUD ALI

Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, Al Safa, Dammam 34222 , Saudi Arabia.

MD. SARFARAZ ALAM

Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

MD. SARFARAZ AHMAD

Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

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RIYASAT, R., M. SHAMIM, J. HARIA, M. D. ALI, M. S. ALAM, and M. S. AHMAD. “DRUG UTILIZATION EVALUATION OF ANGIOTENSIN RECEPTOR BLOCKER (ARB) ALONG WITH THEIR ADRS IN A TERTIARY CARE HOSPITAL”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 11, Sept. 2020, https://innovareacademics.in/journals/index.php/ijpps/article/view/39171.
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