PARTIAL AMORPHIZATION OF POORLY-SOLUBLE SIMVASTATIN USP USING MEDIA MILLING IN SYNERGISM WITH SPRAY-DRYING

  • Dr Harita R. Desai Assistant Professor of Pharmacy, Bombay College of Pharmacy
  • Archana Rajadhyax
  • Prof Purnima Amin

Abstract

Objective: The objective of the current study was to explore top down methods of size reduction like High speed homogenisation and media milling  in synergism with spray-drying in amorphization and solubility enhancement of BCS Class II antilipidemic drug  Simvastatin USP. 


Methods: Spray-dried micronized Simvastatin USP  was formulated by homogenisation and media milling of drug suspension in optimized stabilizer solution. Stabilizer combination, duration of homogenisation and ball milling and drug:stabilizer ratio were optimized.  The obtained dispersion was transformed into solid powder using spray-drying. The obtained Spray-dried micronized Simvastatin USP  was evaluated for visual morphology, Infrared spectroscopy, Differential Scanning Calorimetry, in vitro drug release studies, X-Ray diffractometry, Scanning Electron Microscopy, contact angle measurement, solubility studies, dispersibility studies and intrinsic dissolution rate testing.


Results:  Spray-dried micronized Simvastatin USP  was found to show amorphization of crystalline Simvastatin USP as confirmed by absence of drug peak in Differential scanning calorimetry and lowered signal intensity in X-Ray diffraction studies. Spray-dried micronized Simvastatin USP  was found to show enhanced drug hydrophilicity and solubility as confirmed by lowering in contact angle and increase in solubility and ease of dispersibility observations. In vitro dissolution testing and intrinsic dissolution rate testing were found to show increase in drug release from  11% to 79%  and 4 mg min -1 cm -2 to 17 mg min -1 cm -2 for drug and Spray-dried micronized Simvastatin USP  respectively.


Conclusion: Media milling  in synergism with spray-drying was found to be a prospective  solubility enhancement technique for poorly-soluble Simvastatin USP.

Keywords: Simvastatin, Solubility enhancement, media milling, spray-drying, stabilizer, amorphization, contact angle, homogenization

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Dr Harita R. Desai, Archana Rajadhyax, and Prof Purnima Amin. “PARTIAL AMORPHIZATION OF POORLY-SOLUBLE SIMVASTATIN USP USING MEDIA MILLING IN SYNERGISM WITH SPRAY-DRYING”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 12, no. 11, Sept. 2020, https://innovareacademics.in/journals/index.php/ijpps/article/view/39373.
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