• Abdilkadir Suleyman Addis Ababa University
  • Natesan Gnanasekaran Addis Ababa University Ethiopia.
  • Seifu Daniel Addis Ababa University


Objective: To study the antiglycemic and antidyslipidemic effects of an ethanolic extract of Aloe debrana leaf gel extract in streptozotocin-induced diabetic rats.

Methods: A. debrana leaves were collected from Enemore district; Gurage area Ethiopia. A. debrana gel was obtained from water-washed gel part of A. debrana leaves and homogenized. The resulting mucilaginous, thick and straw colored homogenate was lyophilized and extracted using 95% ethanol. Diabetes was induced in male Wistar rats by streptozotocin (53 mg/kg, i. p.). Diabetic rats were treated with glibenclamide (600µg/kg.) or A. debrana (300 mg/kg) for 28 consecutive days. The blood samples were collected at regular intervals to assess hypoglycemic effect of an ethanolic extract of A. debrana. At the end of the experiment, serum lipid profile were analyzed for all the experimental animals and compared with diabetic control.

Results: The ethanolic extract of A. debrana at 300 mg/kg has significant antiglycemic and antidislipidemic activities. The diabetic control animals exhibited a significant decrease in body weight compared with control animals. A. debrana inhibited streptozotocin-induced weight loss and significantly alter the lipid levels.

Conclusion: The ethanolic extract of A. debrana showed significant antiglycemic and antidislipidemic activities against streptozotocin-induced diabetes in rats.


Keywords: A. debrana, Antiglycemic, Antidyslipidemic


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Author Biography

Natesan Gnanasekaran, Addis Ababa University Ethiopia.

Associate Professor

Dept. of Medical Biochemistry

School of Medicine
College of Health Sciences


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How to Cite
Suleyman, A., N. Gnanasekaran, and S. Daniel. “AMELIORATION OF STREPTOZOTOCIN-INDUCED HYPERGLYCEMIA AND DYSLIPIDEMIA THROUGH ALOE DEBRANA”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 2, Dec. 2014, pp. 290-3,
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