• NIDHI YADAV Department of Zoology, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur
  • RAVI KANT UPADHYAY Department of Zoology, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur




Centipedes, venom glands, toxins, peptides, channel blockers, biochemical and pharmacological properties


The present review article explains venoms from various centipede species with their biomedical and pharmacological properties. Centipede venom is a natural source of bioactive proteins, peptides and other small molecules. These use venoms as defense arsenals to paralyze prey. This review paper sketch out important physiological effects like platelet aggregation, anticoagulant, phospholipase A2 and trypsin inhibiting activity. Centipede venom toxins selectively bind Kv2.1 channel and block them.  Centipede venom disrupts cardiovascular, respiratory, muscular and nervous systems by targeting the broadly distributed KCNQ channels. It also signifies toxin-voltage-gated integrations and its inhibition. These peptides can be used for developing drugs for treatments as well as bio-insecticides for agrochemical.


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Dugon MM, Arthur W.Prey orientation and the role of venom availability in the predatory behaviour of the centipede Scolopendra subspinipes mutilans (Arthropoda: Chilopoda) . J Insect Physiol. 2012; (58) :874-80.

Rádis-Baptista G, Konno K. Artharopod Venom Components and Their Potential Usage . Toxins (Basel) . 2020; (25):12:82.

Norris RF, Kogan M. Ecology of interactions between weeds and arthropods. Annu Rev Entomol. 2005; (50):479-503.

Undheim EA, Jenner RA, King GF.Centipede venoms as a source of drug leads. Expert Opin Drug Discov. 2016; (11):1139-1149.

Jenner RA, von Reumont BM, Campbell LI, Undheim EAB.Parallel Evolution of Complex Centipede Venoms Revealed by Comparative Proteo transcriptomic Analyses. MolBiolEvol. 2019; (36):2748-2763.

Balit CR, Harvey MS, Waldock JM, Isbister GK.Prospective study of centipede bites in Australia. J Toxicol Clin Toxicol. 2004; (42):41-8.

Bouchard NC, Chan GM, Hoffman RS. Vietnamese centipede envenomation. Vet Hum Toxicol. 2004; (46):312-3.

Ross EJ, Jamal Z, Yee J. Centipede Envenomation. In: Stat Pearls . Treasure Island (FL) . 2022 ; (24):

Chen M, Li J, Zhang F, Liu Z. Isolation and characterization of SsmTx-I, a Specific Kv2.1 blocker from the venom of the centipede Scolopendra subspinipes mutilans L. Koch. J Pept Sci. 2014; (20):159-64.

Liu ZC, Zhang R, Zhao F, Chen ZM, Liu HW, Wang YJ . Venomic and transcriptomic analysis of centipede Scolopendra subspinipes dehaani. J Proteome Res. 2012 ; (12):6197-212.

Luo L, Li B, Wang S, Wu F, Wang X, Liang P, Ombati R. Centipedes subdue giant prey by blocking KCNQ channels. Proc Natl Acad Sci U S A. 2018 ; (13):1646-1651.

Ombati R, Luo L, Yang S, Lai R. Centipede envenomation: Clinical importance and the underlying molecular mechanisms. Toxicon. 2018 ; (154):60-6

Liu ZC, Liang JY, Lan XQ, Li T, Zhang JR, Zhao F . Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica. Zool Res. 2020; (18):138-147

Hakim MA, Yang S, Lai R. Centipede venoms and their components: resources for potential therapeutic applications. Toxins (Basel) . 2015 ; (17):4832-51.

Sabiá Júnior EF, Menezes LFS, de Araújo IFS, Schwartz EF. Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites. Toxins (Basel) . 2019; (25): 563.

Garra G, Singer AJ, Leno R, Taira BR, Gupta N, Mathaikutty B, Thode HJ. Heat or cold packs for neck and back strain: a randomized controlled trial of efficacy. Acad Emerg Med. 2010 ; (17):484-9.

Cooper AM, Fox GA, Nelsen DR, Hayes WK. Variation in venom yield and protein concentration of the centipedes Scolopendra polymorpha and Scolopendra subspinipes. Toxicon. 2014 ; (82):30-51

Wang Y, Li X, Yang M, Wu C, Zou Z, Tang J, Yang X. Centipede venom peptide SsmTX-I with two intramolecular disulfide bonds shows analgesic activities in animal models. J Pept Sci. 2017 ; (23):384-391

Schwartz EF, Mourão CB, Moreira KG, Camargos TS, Mortari MR. Arthropod venoms: a vast arsenal of insecticidal neuropeptides. Biopolymers.2012; (4):385-405

Malta MB, Lira MS, Soares SL, Rocha GC, Knysak I, Martins R, Guizze SP, Santoro ML, Barbaro KC.Toxic activities of Brazilian centipede venoms.Toxicon. 2008; (52):255-63.

Rong M, Yang S, Wen B, Mo G, Kang D, Liu J.Peptidomics combined with cDNA library unravel the diversity of centipede venom. J Proteomics. 2015; (30):114:28-37

González-Morales L, Pedraza-Escalona M, Diego-Garcia E, Restano-Cassulini R, Batista CV, Gutiérrez Mdel C, Possani LD. Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis. J Proteomics. 2014; (5):224-37.

Undheim EA, Fry BG, King GF: Centipede venom. recent discoveries and current state of knowledge. Toxins (Basel) . 2015; (25):679-704.

Robles JT, Valverde FF, Cisneros LV, Villeda JH, Sánchez-Reyes A, Gutiérrez MDC. Mitochondrial activity disruption and local muscle damage induced in mice by Scolopendra polymorpha venom. J Venom Anim Toxins Incl Trop Dis. 2020; (29):20190079

Kimura LF, Prezotto-Neto JP, Távora Bde C, Antoniazzi MM, Knysak I, Gióia Guizze SP, Santoro ML, Barbaro KC. Local inflammatory reaction induced by Scolopendra viridicornis centipede venom in mice. Toxicon.2013; (76):239-46.

Távora BC, Kimura LF, Antoniazzi MM, Chiariello TM, Faquim-Mauro EL, Barbaro KC. Involvement of mast cells and histamine in edema induced in mice by Scolopendra viridicornis centipede venom. Toxicon. 2016; (121):51-60.

Zhu A, Aierken A, Yao Z, Vu S, Tian Y, Zheng J, Yang S, Yang F. A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel.. Toxicon. 2020; (178):41-49.

Ward MJ, Rokyta DR. Venom-gland transcriptomics and venom proteomics of the giant Florida blue centipede, Scolopendra viridis. Toxicon. 2018; (15):121-136.

Yang S, Wang Y, Wang L, Kamau P, Zhang H, Luo A, Lu X, Lai R. Target switch of centipede toxins for antagonistic switch. Sci Adv. 2020 ; (7):5734.

Du C, Li J, Shao Z, Mwangi J, Xu R, Tian H, . Centipede KCNQ Inhibitor SsTx Also Targets KV1.3. Toxins (Basel) . 2019 ; 1; (11):76

Hamanaka K, Mori A. Toxicity of venom from the mamushi, Gloydius blomhoffii, (Squamata, Crotalinae) to centipedes. Toxicon. 2020; (188):11-15.

Herzig V: Arthropod assassins: Crawling biochemists with diverse toxin pharmacopeias. Toxicon.2019 ; (158):33-37.

Fratini F, Cilia G, Turchi B, Felicioli A. Insects, arachnids and centipedes venom: A powerful weapon against bacteria. A literature review. Toxicon. 2017 ; (130):91-103

Kong, Y., Huang, S. L., Shao, Y., Li, S. & Wei, J. F.Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans. Journal of Ethnopharmacology . 2013 ; (145):182–186

Pemberton R.W. Insects and other arthropods used as drugs in korean traditional medicine. J. Ethnopharmacol. 1999 ; (65):207–216.

Khusro A, Aarti C, Barbabosa-Pliego A, Rivas-Cáceres RR, Cipriano-Salazar M.Venom as therapeutic weapon to combat dreadful diseases of 21st century: A systematic review on cancer, TB, and HIV/AIDS. Microb Pathog. 2018 ; (125):96-107.

Wang C, Shan B, Wang Q, Xu Q, Zhang H, Lei H. Fusion of Ssm6a with a protein scaffold retains selectivity on NaV 1.7 and improves its therapeutic potential against chronic pain. Chem Biol Drug Des. 2017 ; (89):825-833.

Peng K, Kong Y, Zhai L, Wu X, Jia P, Liu J, Yu H.Two novel antimicrobial peptides from centipede venoms. Toxicon.2010 ; (55 ):274-9.

Lan XQ, Zhao F, Wang QQ, Li JH, Zeng L, Zhang Y, Lee WH. Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans. Allergol Int. 2021 ; (70):121-128.

Lee JH, Kim IW, Kim SH, Kim MA, Yun EY, Nam SH, Ahn MY.Anticancer Activity of the Antimicrobial Peptide Scolopendrasin VII Derived from the Centipede, Scolopendra subspinipes mutilans. J Microbiol Biotechnol. 2015 ; (25):1275-80.

Park YJ, Lee HY, Jung YS, Park JS, Hwang JS, Bae YS. Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1. BMB Rep. 2015 ; (48):479-84.

Park YJ, Park B, Lee M, Jeong YS, Lee HY, Sohn DH, Song JJ, Lee JH.A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis.. Sci Rep. 2018 ; (2):14664.

Hou H, Yan W, Du K, Ye Y, Cao Q, Ren W. Construction and expression of an antimicrobial peptide scolopin 1 from the centipede venoms of Scolopendra subspinipes mutilans in Escherichia coli using SUMO fusion partner. Protein Expr Purif. 2013 ; (92):230-4.

Chaparro-Aguirre E, Segura-Ramírez PJ, Alves FL, Riske KA, Miranda A, SilvaJúnior PI.Antimicrobial activity and mechanism of action of a novel peptide present in the ecdysis process of centipede Scolopendra subspinipes subspinipes. Sci Rep. 2019 ; (20):13631.

Ali SM, Siddiqui R, Sagathevan KA, Khan NA.Antibacterial activity of selected invertebrate species. Folia Microbiol (Praha) . 2021 ; (66):285-291.

Yoo WG, Lee JH, Shin Y, Shim JY, Jung M, Kang BC, Oh J, Seong J, Lee HK.: Antimicrobial peptides in the centipede Scolopendra subspinipes mutilans. Funct Integr Genomics. 2014 ; (14):275-83.

Choi H, Hwang JS, Lee DG.Identification of a novel antimicrobial peptide, scolopendin 1, derived from centipede Scolopendra subspinipes mutilans and its antifungal mechanism. Insect Mol Biol. 2014 ; (23):788-99.

Lee H, Hwang JS, Lee DG. Scolopendin, an antimicrobial peptide from centipede, attenuates mitochondrial functions and triggers apoptosis in Candida albicans. Biochem J. 2017; (20): 635-645.

Lee H, Hwang JS, Lee J, Kim JI, Lee DG. Scolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism. Biochim Biophys Acta. 2015 ; (1848):634-42.

Kwon YN, Lee JH, Kim IW, Kim SH, Yun EY, Nam SH, Ahn MY. Antimicrobial activity of the synthetic peptide scolopendrasin ii from the centipede Scolopendra subspinipes mutilans. J MicrobiolBiotechnol. 2013 ; (28):1381-5.

Park YJ, Kim HS, Lee HY, Hwang JS, Bae YS. A novel antimicrobial peptide isolated from centipede Scolopendra subspinipes mutilans stimulates neutrophil activity through formyl peptide receptor 2. Biochem Biophys Res Commun.2017 ; (9):352-357.

Primon-Barros M, José Macedo A. Animal Venom Peptides.Potential for New Antimicrobial Agents. Curr Top Med Chem. 2017 ; (17):1119-1156.

Smith JJ, Undheim EAB. True Lies: Using Proteomics to Assess the Accuracy of Transcriptome-Based Venomics in Centipedes Uncovers False Positives and Reveals Startling Intraspecific Variation in Scolopendra subspinipes. Toxins (Basel) .2018 ; (28):10:96.

Zhao F, Lan X, Li T, Xiang Y, Zhao F, Zhang Y, Lee WH. Proteotranscriptomic Analysis and Discovery of the Profile and Diversity of Toxin-like Proteins in Centipede. Mol Cell Proteomics. 2018 ; (17):709-720.

Ellsworth SA, Nystrom GS, Ward MJ, Freitas de Sousa LA, Hogan MP, Rokyta DR. Convergent recruitment of adamalysin-like metalloproteases in the venom of the red bark centipede (Scolopo cryptops sexspinosus) . Toxicon.2019 ; (168):1-15.

De Lucca Caetano LH, Nishiyama-Jr MY, de Carvalho Lins Fernandes Távora B, de Oliveira UC. Recombinant Production and Characterization of a New Toxin from Cryptopsi heringi Centipede Venom Revealed by Proteome and Transcriptome Analysis. Toxins (Basel) . 2021 ; ( 2):858.

Preet P. Peptides: a new therapeutic approach. Int J Curr Pharm Res. 2018 ; (10):29-34.

Ahluwalia, S., and N. Shah. “ Animal venom for treating breast cancer”. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; (6 ): 24-30.

Mohd, K. S., M. A.- kassim Hassan, W.- atirah Azemin, and S. Dharmaraj. “A review of potential anticancers from antimicrobial peptides” . International Journal of Pharmacy and Pharmaceutical Sciences. 2015; (7): 19-26.

Kumar RB, MX Suresh. Neurotox: a unique database for animal neurotoxins. Int J Pharm Pharm Sci 2015;7:351-4.

Asawale KY, MC Mehta, P S. Uike. Drug utilization analysis of anti-snake venom at a tertiary care centre in central Maharasthtra: a 3y retrospective study. Asian J Pharm Clin Res 2018;11:134-7.

Preet P. Peptides: a new therapeutic approach. Int J Curr Pharm Res 2018;10:29-34.



How to Cite

YADAV, N., and R. K. UPADHYAY. “CENTIPEDE VENOM TOXINS AND ITS BIOMEDICAL AND PHARMACOLOGICAL PROPERTIES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 14, no. 9, July 2022, doi:10.22159/ijpps.2022v14i9.45488.



Review Article(s)