PROMISING NEUROPROTECTIVE PLANTS FROM NORTH-EAST INDIA


Pankaj Phukan, Meenakshi Bawari, Mahuya Sengupta

Abstract


Neuroprotection is a broad term commonly used to refer therapeutic strategies that can prevent, delay or even reverse neuronal damage. Herbal medicines are widely used across the globe as economical, effective and safer alternative remedies. North-East (NE) India harbours a large number of medicinal plants, it falls under Indo-Burma global hotspot one of the 34 global biodiversity hotspots. In traditional practice of medicines, people here uses a variety of medicinal plants for the treatment of various ailments. The purpose of this manuscript is to review the plants with neuroprotective potential from NE India and to provide the reference for future study of new and alternative remedies for the treatment of neurological ailments.

 

 


Keywords


Neuroprotection, North-East India, Herbal Medicine, Neurotoxicity, Neuroprotective plant

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References


Pimplikar Sanjay W. Reassessing the amyloid cascade hypothesis of Alzheimer’s disease. Int J Biochem Cell Biol 2009;41(6):1261-8.

Reitz Christiane. Alzheimer’s disease and the amyloid cascade hypothesis: a critical review. Int J Alzheimer’s Dis 2012;2012:1-11.

D’Amelio Marcello, Sheng Morgan, Cecconi Francesco. Caspase-3 in the central nervous system: beyond apoptosis. Trends Neurosci 2012;35(11):700-9.

Bosch L Van Den, Damme P Van, Bogaert E, Robberecht W. The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta 2006;1762(11-12):1068-82.

Olney JW, Excitotoxicity: an overview. Can Dis Wkly Rep 1990;16(Suppl 1E):47-57.

Ndountse LT, Chan HM. Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity. Toxicol Lett 2009;184:50-5.

Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders, Sci 1993;262:689-95.

Perluigi Marzia, Coccia Raffaella, Butterfield D Allan. 4-Hydroxy-2-Nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxidants Redox Signalling 2012;17(11):1590-609.

Smitha Joshua A, Dasa Arabinda, Rayb Swapan K, Banika Naren L. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 2012;87:10-20.

Francis Paul T, Palmer Alan M, Snape Michael, Wilcock Gordon K. The cholinergic hypothesis of Alzheimer’s disease: a review of progress. J Neurol Neurosurg Psychiatry 1999;66:137-47.

Paithankar VV, Belsare SL, Charde RM, Vyas JV. Acorus Calamus: an overview, Int J Biomed Res 2011;2(10):518‐29.

Pattanaik Jina, Kumar Yogesh, Khatri Ravi Shankar. Acorus calamus Linn: a herbal tonic for central nervous system. J Sci Innovative Res 2013;2(5):950-4.

Howes MR, Houghton PJ. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behavior 2003;75:513-27.

Kumar Amit, Vandana. Medicinal properties of Acorus Calamus. J Drug Delivery Ther 2013;3(3):143-4.

Shukla PK, Khanna VK, Ali MM, Maurya R, Khan MY, Srimal RC. Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat. Hum Exp Toxicol 2006;25(4):187-94.

Chawla Amit, Chawla Payal, Mangalesh, Roy RC. Asparagus racemosus (Willd): biological activities & its active principles. Indo-Global J Pharm Sci 2011;1(2):113-20.

Negi JS, Singh P, Joshi GP, Rawat MS, Bisht VK. Chemical constituents of Asparagus. Pharmacogn Rev 2010;4(8):215–20.

Shao Y, Poobrasert O, Kennelly EJ, Chin CK, Ho CT, Huang MT, et al. Steroidal saponins from Asparagus officinalis and their cytotoxic activity. Planta Med 1997;63:258-62.

Sairam KS, Priyambada NC, Goel RK. Gastroduodenal ulcer protective activity of Asparagus racemosus: an experimental, biochemical and histological study. J Ethnopharmacol 2003;86(1):1-10.

Kamat JP, Boloor KK, Devasagayam T, Venkatachalam S. Antioxidant properties of Asparagus racemosus against damage induced by γ-radiation in rat liver mitochondria. J Ethnopharmacol 2000;71:425-35.

Venkatesan N, Thiyagarajan V, Narayanan S, Arul A, Raja S, Gurusamy S. Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals. J Pharm Pharm Sci 2005;8:39-46.

Thakur M, Connellan P, Deseo MA, Morris C, Praznik W, Loeppert R, et al. Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Wild. Int J Biol Macromol 2011;50:77-81.

Dhingra D, Kumar V. Pharmacological evaluation for antidepressant-like activity of Asparagus racemosus Wild in mice. Pharmacologyonline 2007;3:133-52.

Meena J, Ojha R, Muruganandam A, Krishnamurthy S. Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes. Neurosci Lett 2011;503:6-9.

Parihar M, Hemnani T. Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus. J Neural Transm 2004;111:1-12.

Laddawan Lalert, Hathairat Kruevaisayawan, Patcharada Amatyakul, Onrawee Khongsombat. Neuroprotective effects of the Asparagus racemosus root extract on ovariectomized rats. J Physiol Biomed Sci 2013;26(1):18-22.

Srivastava Shikha, Mishra Nidhi, Misra Upama. Bacopa monniera-a future perspective. IJPSDR 2009;1(3):154-7.

Sudharani D, Krishna KL, Deval K, Safia AK, Priya. Pharmacological profiles of Bacopa monnieri: a review. Int J Pharm 2011;1(1):15-23.

Nongnut Uabundit, Jintanaporn Wattanathorn, Supaporn Mucimapura, Kornkanok Ingkaninan. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease model. J Ethnopharmacol 2010;127:26-31.

Singh HK, Dhawan BN. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol 1997;29(5):359-65.

Nanteetip Limpeanchob, Somkiet Jaipan, Saisunee Rattanakaruna, Watoo Phrompittayarat, Kornkanok Ingkaninan. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. J Ethnopharmacol 2008;120:112-7.

Ravishankar B, Shukla VJ. Indian system of medicine: a brief profile. Afr J Tradit Complementary Altern Med 2007;4(3):319-37.

Basu NK, Pabrai PR. Chemical investigation of Celastrus paniculata Willd. J Am Pharm Assoc 2006;35(9):272-3.

Yasu LU, Yang S, Zou Z, Chen H, Zhen X, Zhongemei Z, et al. Evoninoate sesquiterpene alkaloids from the stem of Celastrus paniculatus. Heterocycl 2006;68(2):1241-7.

Tu YQ, Chen YZ, Wu DG, Zhang XM, Hao JX. Sesquiterpene polyol esters from Celastrus paniculatus. J Nat Prod 1991;54(2):1383-6.

Kumar MHV, Gupta YK. Antioxidant property of Celastrus paniculatus willd: a possible mechanism in enhancing cognition. Phytomed 2002;9(4):302-11.

Zheng C, Qin L. Chemical components of Centella asiatica and their bioactivities. J Chin Integr Med 2007;5:348-51.

Jamil SS, Nizami Q, Salam M, Urban L. Centella asiatica L. urban a review. Nat Prod Rad 2007;6:158-70.

Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol 2008;116:325-32.

Nasir MN, Abdullah J, Habsah M, Ghani RI, Rammes G. Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity. Phytomed 2012;19(3-4):311-6.

Rao SB, Chetana M, Uma Devi P. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiol Behavior 2005;86:449-57.

Orhan G, Orhan I, Sener B. Recent developments in natural and synthetic drug research for Alzheimer’s disease. Lett Drug Des Discovery 2006;3(4):268-74.

Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 2007;21(12):1142-5.

Suguna L, Sivakumar P, Chandrakasan G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol 1996;34(12):1208-11.

Somchit MN, Sulaiman MR, Zuraini A, Samsuddin L, Somchit N, Israf DA, et al. Antinociceptive and antiinflammatory effects of Centella asiatica. Indian J Pharmacol 2004;36(6):377-80.

Sampson JH, Raman A, Karlsen G, Navsaria H, Leigh I. In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomed 2001;8(3):230-5.

Cheng CL, Guo JS, Luk J, Koo MWL. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats. Life Sci 2004;74(18):2237-49.

Pingale SS. Evaluation of effect of Centella asiatica on CCL4 induced rat liver damage. Pharmacologyonline 2008;3:537-43.

Sudha S, Kumaresan S, Amit A, David J, Venkataraman BV. Anti-convulsant activity of different extracts of Centella asiatica and Bacopa monnieri in animals. J Nat Rem 2002;2(1):33-41.

Wijeweera P, Arnason JT, Koszycki D, Merali Z. Evaluation of anxiolytic properties of Gotukola-(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomed 2006;13(9-10):668-76.

Wang XS, Dong Q, Zuo JP, Fang JN. Structure and potential immunological activity of a pectin from Centella asiatica (L.) Urban. Carbohydr Res 2003;338(22):2393-402.

Gnanapragasam A, K Kumar Ebenezar, Sathish V, Govindaraju P, Devaki T. Protective effect of Centella asiatica on antioxidant tissue defense system against Adriamycin induced cardiomyopathy in rats. Life Sci 2004;76(5):585-97.

Venu Gopal Rao ML, Mastan SA. Antidiabetic effects of methanolic extract of Centella asiatica (Linn.) on induced hyperglycemic rats. Biosci Biotechnol Res Asia 2007;4(2):721-4.

Bunpo P, Kataoka K, Arimochi H, Nakayama H, Kuwahara T, Bando Y, et al. Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats. Food Chem Toxicol 2004;42(12):1987-97.

Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomed 2000;6(6):411-9.

Zaidan MR, Rain A Noor, Badrul AR, Adlin A, Norazah A, Zakiah I. In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. Trop Biomed 2005;22(2):165-70.

Senthilkumar N, Varma P, Gurusubramanian G. Larvicidal and adulticidal activities of some medicinal plants against the Malarial Vector, Anopheles stephensi(Liston). Parasitol Res 2009;104(2):237-44.

Naz E, Ahmad M. Evaluation of five indigenous medicinal plants of Sindh, Pakistan for their antifungal potential. Pakistan J Sci Industrial Res 2009;52(6):328-33.

Jayashree G, Muraleedhara G Kurup, Sudarslal S, Jacob VB. Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice. Fitoterapia 2003;74(5):431-4.

Chaudhuri S, Ghosh S, Chakraborty T. Use of a common Indian herb “Mandukaparni” in the treatment of leprosy. (Preliminary report). J Indian Med Assoc 1978;70(8):177-80.

Pointel JP, Boccalon H, Cloarec M. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38(1):46-50.

Mir H. Coriandrum sativum In: Application of plants in prevention and treatment of illnesses. Persian 1992;1:257-2.

Meloa EA, Filhob JM, Guerrac NB. Characterizations of antioxidant compounds in aqueous coriander extract (Coriandrum sativum L.). Lebensm-Wiss Technol 2005;38:15-9.

Matasyoh JC, Maiyo ZC, Ngure RM, Chepkorir R. Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum. Food Chem 2009;113:526-9.

Cortes-Eslava J, Gomez-Arroyo S, Villalobos-Pietrini R. Antimutagenicity of coriander (Coriandrum sativum) juice on the mutagenesis produced by plant metabolites of aromatic amines. Toxicol Lett 2004;153:283-92.

Eguale T, Tilahun G, Debella A, Feleke A, Makonnen E. In vitro and in vivo anthelmintic activity of crude extracts of Coriandrum sativum against Haemonchus contortus. J Ethnopharmacol 2007;110:428-33.

Emamghoreishi M, Heidari-Hamedani G. Sedative-Hypnotic activity of extracts and essential oil of Coriander seeds. Iran J Med Sci 2006;31(1):22-7.

Hosseinzadeh H, Madanifard M. Anticonvulsant effect of Coriander sativum L. seed extracts in mice. Iran J Pharm 2005;3:1-4.

Abderahim A, El-Hilaly J, Israili ZH, Lyoussi B. Acute diuretic effect of continuous intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats. J Ethnopharmacol 2008;115:89-95.

Dhanapakiam P, Joseph JM, Ramaswamy VK. The cholesterol lowering property of Coriander seeds (Coriandrum sativum): Mechanism of action. J Environ Biol 2008;29(1):53-6.

Filomena S, Susana F, Andreia D. Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B. Phytomed 2011:1-6.

Catherine JD, Ian FH, Peter W, Lucy DL. Action of extracts of apiaceae on feeding behavior and neurophysiology of the field slug Deroceras reticulatum. J Chem Ecol 1999;25(9):2127-47.

Chithra V, Leelamma. Coriandrum sativum-effect on lipid metabolism in 1, 2-dimethyl hydrazine induced colon cancer. J Ethnopharmacol 2000;71:457-63.

Masoumeh E, Mohammad K, Maryam FA. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. J Ethnopharmacol 2005;96:365-70.

Pandey A, Bigoniya P, Raj V, Patel KK. Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity. J Pharm BioAllied Sci 2011;3(3):435-41.

Fernanda CM, Claudia ML, Marina PA. In vitro effect of Aloe vera, Coriandrum sativum and Ricinus communis fractions on Leishmania infantum and on murine monocytic cells. Vet Parasitol 2011;178:235-40.

Al-Mofleha A, Alhaider AA, Mossa JS. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environ Toxicol Pharmacol 2006;22:64-9.

Mansoor SA, Al-khamis KI, Mohammad WI. Post-coital antifertility activity of the seeds of Coriadrum sativum in rats. J Ethnopharmacol 1987;21:165-73.

Karunasagar D, Balarama Krishna MV, Rao SV, Arunachalam J. Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum sativum. J Hazard Mater 2005;118:133-9.

Mahendra P, Bisht S. Anti-anxiety activity of Coriandrum sativum assessed using different experimental anxiety models. J Pharmacol 2011;43(5):574-7.

Vekaria RH, Patel MN, Bhalodiya PN, Patel V, Desai TR, Tirgar PR. Evaluation of neuroprotective effect of Coriandrum sativum linn. against ischemic-reperfusion insult in brain. Int J Phytopharmacol 2012;3(2):186-93.

Vasudevan Mani, Milind Parle. Memory-enhancing activity of Coriandrum sativum in rats. Pharmacologyonline 2009;2:827-39.

Vijaya Bhargava K. Medicinal uses and pharmacological properties of Crocus sativus linn (saffron). Int J Pharm Pharm Sci 2011;3 Suppl 3:22-6.

Kataria D, Kumar C, Nerkar N, Gadiya RV, Abhyankar MM. Detail profile of Crocus sativus. Int J Pharma Bio Sci 2011;2(1):530-40.

Srivastava R, Ahmed H, Dixit RK, Dharamveer, Saraf SA. Crocus sativus L.: A comprehensive review. Pharmacogn Rev 2010;4(8);200-8.

Kazuho A, Minoru S, Yukihiro S, Hiroshi S. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Brain Res 1998;787:132-8.

Ahmad AS, Ansari MA, Ahmad M, Saleem S, Yousuf S, Hoda MN, et al. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behavior 2005;81:805-13.

Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Marqarity M, et al. Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem 2006;54(23):8762-8.

Pitsikas N, Boultadakis A, Georgiado G, Tarantilis PA, Sakellaridis N. Effects of the active constituents of Crocus sativus L, crocins, in an animal model of anxiety. Phytomed 2008;15:1135-9.

Mukherjee Pulok K, Kumar Venkatesan, Kumar N Satheesh, Heinrich Micheal. The Ayurvedic medicine Clitoria ternatea-from traditional use to scientific assessment. J Ethnopharmacol 2008;120:291-301.

Rai KS, Murthy KD, Karanth KS, Rao MS. Clitoria ternatea (Linn) root extract treatment during growth spurt period enhances learning and memory in rats. Indian J Physiol Pharmacol 2001;45(3):305-13.

Kulkarni C, Pattanshetty JR, Amruthraj G. Effect of alcoholic extract of Clitoria ternatea Linn. on central nervous system in rodents. Indian J Exp Biol 1988;26:957-60.

Taranalli AD, Cheeramkuzhy TC. Influence of Clitoria ternatea extracts on memory and central cholinergic activity in rats. Pharm Biol 2000;38(1):51-6.

Rai KS, Murthy KD, Karanth KS, Nalini K, Rao MS, Srinivasan KK. Clitoria ternatea root extract enhances acetylcholine content in rat hippocampus. Fitoterapia 2002;73(7-8):685-9.

Kumar Nitesh, Sakhya Sunil Kumar. Ethnopharmacological properties of Curcuma longa: a review. IJPSR 2013;4(1):103-12.

Monograph, Curcuma longa, Alternative Medicine Review Monographs; 2002. p. 119-25.

Rajakrishnan V, Viswanathan P, Rajasekharn KN, Menon VP. Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage. Phytother Res 1999;13(7):571-4.

Kim DS, Park SY, Kim JK. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci Lett 2001;303:57-61.

Yu ZF, Kong LD, Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice. J Ethnopharmacol 2002;83(1-2):161-5.

Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci 2006;78(18):2081-7.

Ghoneim AI, Abdel-Naim AB, Khalifa AE, EI-Denshary ES. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 2002;46(3):273-9.

Ramirez Bosca A, Soler A, Gutierrez MA, Alvarez JL, Almagro EQ. Antioxidant Curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age 1995;18(4):167-9.

Jadhav VM, Thorat RM, Kadam VJ, Salaskar KP. Chemical composition, pharmacological activities of Eclipta alba. J Pharm Res 2009;2(8):1129-31.

Sharma Manik, Yusuf Muhammad, Hussain Showkat, Hussain Abrar. Phytochemical constituents and pharmacological activities of Eclipta alba linn (asteraceae): a review. Int Res J Pharm 2012;3(12):51-3.

Sawant M, Isaac JC, Narayanan S. Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk. Phytother Res 2004;18(2):111-3.

Lobo OJ, Banjid, Annamalai AR, Manavalan R. Evaluation of anti-aggressive activity of Eclipta alba in experimental animals. Pak J Pharm Sci 2008;21(2):195-9.

Pandey MK, Singh GN, Sharma RK, Lata S. Antibacterial activity of Eclipta alba (L.) Hassk. J Appl Pharm Sci 2011;01(07):104-7.

Chaudhary H, Dhuna V, Singh J, Kamboj SS, Seshadri S. Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: an in vitro study. J Ethnopharmacol 2011;136(2):363-7.

Hemalatha S, Ayyappan T, Shanmugan S, Nagavalli D, Shrivijaya kirubha T. Evaluation of antidiabetic and diuretic activity of polyherbal formulation. Indian J Traditional Knowledge 2006;5(4):468-70.

Sujata CG, Chaudhary RS, Chavan MJ. Antihelmenthic potential of Eclipta alba (L.) Hassk against Pheretima phosthoma. Int J Pharm Pharm Sci 2011;3(1):143­4.

Athokpam Rojini, Bawari Meenakshi, Choudhury Manabendra Dutta. A review on medicinal plants of Manipur with special reference to hepatoprotection. Int J Adv Pharm Res 2014;5(3):182-91.

Arunachalam G, Subramanian N, Pazhani GP, Ravichandran V. Anti-inflammatory activity of methanolic extract of Eclipta prostrate L. (Astearaceae). Afr J Pharm Pharmacol 2009;3(3):97-100.

Datta K, Anu TS, Mukherjee A, Bhat B, Ramesh B, Anand CB. Eclipta alba extract with potential for hair growth promoting activity. J Ethnopharmacol 2009;124:450-6.

Banji O, Banji D, Annamalai AR, Manavalan R. Investigation on the effect of Eclipta alba on animal models of learning and memory. Indian J Physiol Pharmacol 2007;51:274-8.

Mansoorali KP, Prakash T, Kotresha D, Prabhu K, Rao N Rama. Cerebroprotective effect of Eclipta alba against global model of cerebral ischemia induced oxidative stress in rats. Phytomed 2012;19:1108-16.

Dutta Jayashree. Phytochemicals analysis and tlc fingerprinting of methanolic extracts of three medicinal plants. Int Res J Pharm 2013;4(6):123-6.

Rahman MT, Gegum N. Analgesic activity of Enhydra fluctuans. Fitoterapia 2002;73(7-8):654-60.

Amin R, Mondol R, Habib MR, Hossain MT. Antimicrobial and cytotoxic activity of three bitter plants-Enhydra fluctuans, Andrographis peniculata and Clerodendrum viscosum. Adv Pharm Bull 2012;2(2):207-11.

Patil KS, Majumder P, Wadekar RR. Effect of Enhydra fluctuans Lour. leaf extract on phagocytosis by human neutrophils. J Nat Rem 2008;8(1):76-81.

Bhakta JN, Majumdar P, Munekage Y. Antimicrobial efficacies of methanol extract of Asteracantha longifolia, Ipomoea aquatic and Enhydra fluctuans against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Micrococcus luteus. Internet J Alternative Med 2009;7(2):125-35.

Kumar Swain Pramod, Jagnnath Patro V, Chandra Dinda Subas, Prasan Nayak Durga. Hepatoprotective activity of Enhydra fluctuans lour aerial parts against ccl4 induced hepatotoxicity in rats. Int J Res Ayurveda Pharm 2012;3(6):893-6.

Haldar Sagnik, Kar Biswakanth, Dolai Narayan, RB Suresh, Behera Biswaranjan, Haldar Pallab Kanti. In vivo anti-nociceptive and anti-inflammatory activities of Lippia alba. Asian Paicfic J Trop Dis 2012;2 Suppl 2:S667-S670.

Uddin SJ, Ferdous MM, Rouf R. Evaluation of anti-diarrheal activity of Enhydra fluctuans. Med Sci 2011;5(4):324-7.

Swain PK, Dinda1 SC, Nayak DP, Kar B, Patro VJ. Antioxidant activity of Enhydra fluctuans Lour. aerial parts. J Phytother Pharmacol 2012;1(2):23-34.

Sannigrahi S, Mazumder UK, Mondal A, Pal D, Mishra SL, Roy S. Flavonoids of Enhydra fluctuans exhibit anticancer activity against Ehrlich's ascites carcinoma in mice. Nat Prod Commun 2010;5(8):1239-42.

Roy SK, Mazumder U, Islam A. Pharmacological evaluation of Enhydra fluctuans aerial parts for central nervous system depressant activity. Pharmacologyonline 2011;1:632-43.

Taro N, Toshio F, Toshiyuki A. Chemistry of phenolic compounds of licorice & their estrogenic and cytotoxic activities. J Pure Appl Chem 2002;74(7):1199-206.

Lee CK, Park KK, Lim SS. Effects of licorice extracts against tumor growth & cisplatin induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull 2007;30:2191-5.

Kalaigandhi V, Poovendran P. Antimicrobial activity of Glycyrrhiza glabra against peptic ulcer produced Helicobacter pylori. Int J Curr Pharm Res 2011;3:93-5.

Latif M, Iqbal L, Fatima N. Evaluation of antioxidant & urease inhibition activity of roots of Glycyrrhiza glabra. Pakistan J Pharm Sci 2012;25:99-102.

Mazumdar PM, Patnayak SP, Parwani H. Evaluation of immunomodulatory activity of Glycyrrhiza glabra roots in combination with zinc. Asian Pac J Trop Med 2012;S15-S20.

Kalaigandhi V, Poovendran P. Antimicrobial activity of Glycyrrhiza glabra against peptic ulcer produced Helicobacter pylori. Int J Curr Pharm Res 2011;3(4):93-5.

Mirmala P, Selvaraj T. Anti-inflammatory & antibacterial activities of Glycyrrhiza glabra. J Agricu Technol 2011;7:815-23.

Yazdi A, Sardari S, Sayyah Md. Evaluation of anticonvulsant activity of leaves of Glycyrrhiza glabra grown in Iran as a possible renewable source for anticonvulsant compounds. Iran J Pharm Res 2011;10(1):75-82.

Yu XQ, Xue CC, Zhou ZW, Li CG, Du YM, Liang J, et al. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci 2008;82:68-78.

Muralidharan P, Balamurugan G, Babu Venu. Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract on hypoxic rats. Bangladesh J Pharmacol 2009;4:60-4.

Dhingra Dinesh, Parle Milind, Kulkarni SK. Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharmacol 2004;91:361-5.

Teltumbde AK, Wahurwagh AK, Lonare MK, Nesari TM. Effect of Yashtimadhu (Glycyrrhiza Glabra) on intelligence and memory function in male adolescents. Scholars J Appl Med Sci 2013;1(2):90-5.

Ma X, Tan C, Yuan Zhu DA, Gang DR, Peigen X. Huperzine A from Huperzia species-an ethnopharmacological review. J Ethnopharmacol 2007;113:15-34.

HB Singh, Singh Manish Kumar. Huperzia serrata: a promising medicinal pteridophyte from Northeast India. NeBIO 2010;1(1):27-34.

Liu JS, Zhu YL, Yu CM, Zhou YZ, Han YY, Wu FW, et al. The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity. Canadian J Chem 1986;64:837-9.

Liu L, Sun JX. Advances on study of organophosphate poisoning prevented by huperzine A. Wei Sheng Yan Jiu 2005;34:224-6.

Han Yan, Lin Li, Xi Can Tang. Treating senile dementia with traditional Chinese medicine. Clin Interventions Aging 2007;2(2):201-8.

Chang LW, Juang LJ, Wang BS, Wang MY, Tai HM, Hung WJ, et al. Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark. Food Chem Toxicol 2011;49:785-90.

Doi K, Kojima T, Makino M, Kimura Y, Fujimoto Y. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull 2001;49:151-3.

Jamshid M, Prakash RN. The histopathologic effects of Morus alba leaf extract on the pancreas of diabetic rats. Turk J Biol 2012;36:211-6.

Aditya RSJ, Ramesh CK, Riaz M, Prabhakar BT. Anthelmintic and antimicrobial activities in some species of mulberry. Int J Pharm Pharm Sci 2012;4 Suppl 5:335-8.

Shahid I, Umer Y, Sirajuddin, Kim WC, Raja AS, Kamal U. Proximate composition and antioxidant potential of leaves from three varieties of mulberry (Morus sp.): a comparative study. Int J Mol Sci 2012;13:6651-64.

Yadav AV, Kawale1 LA, Nade VS. Effect of Morus alba L. (mulberry) leaves on anxiety in mice. Indian J Pharmacol 2008;40 Suppl 1:32-6.

Venkatachalam VV, Kannan K, Ganesh S. Preliminary immunomodulatory activities of aqueous extract of Morus alba linn. Int J Chem Sci 2009;7 Suppl 4:2233-8.

Nematbakhsh M, Hajhashemi V, Ghannadi A, Talebi A, Nikahd M. Protective effects of the Morus alba L. leaf extracts on cisplatin induced nephrotoxicity in rats. Res Pharm Sci 2013;8 Suppl 2:71-7.

Tian J, Fu F, Geng M, Jiang Y, Yang J, Jiang W, et al. Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett 2005;374:92-7.

Kang TH, Oh HR, Jung SM, Ryu JH, Park MW, Park YK, et al. Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage. Biol Pharm Bull 2006;29:270-4.

Kang TH, Hur JY, Kim HB, Ryu JH, Kim SY. Neuroprotective effects of the cyanidin-3-O-β-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia. Neurosci Lett 2006;391:168-72.

Kim HG, Ju MS, Shim JS, Kim MC, Huh SHLY, Kim SY, et al. Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson’s disease models. Brit J Nutr 2010;104:8-16.

Niidome T, Takahashi K, Goto Y, Goh SM, Tanaka N, Kamei K. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. Neuroreport 2007;18:813-6.

Shama S Neelufar. A mine of medicinal uses: Ocimum sanctum, the holy basil. Int J Pharm Rev Res 2012;2(2):69-74.

Singh S, Majumdar KD. Analgesic activity of Ocimum sanctum and its possible mechanism of action. Pharm Biol 1995;33:188-92.

Ghangale GR, Mahale T, Jadhav ND. Evaluation of antiulcer activity of Ocimum sanctum in rats. Vet World 2009;2:465-6.

Singh S, Majumdar DK. Effect of fixed oil of Ocimum sanctum against experimentally induced arthritis and joint edema in laboratory animals. Int J Pharmacog 1996;34(3):218-22.

Jeba CR, Vaidyanathan R, Rameshkumar G. Immunomodulatory activity of aqueous extract of Ocimum sanctum in rat. Int J Pharm Biomed Res 2011;2:33-8.

Singh S, Aggarwal SS. Antiasthmatic and anti-inflammatory activity of Ocimum sanctum. Int J Pharmacogn 1991;29:306-10.

Jaggi RK, Madaan R, Singh B. Anticonvulsant potential of holy basil, Ocimum sanctum Linn and its cultures. Ind J Exp Biol 2003;41:1329-33.

Patil R, Patil R, Ahirwar B, Ahirwar D. Isolation and characterization of antidiabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part. Asian Pac J Trop Med 2011;4:278-82.

Singh B, Jaggi KR. Anti-inflammatory effect of Ocimum Sanctum Linn and its cultures. Indian J Pharm Sci 2003;65:425-8.

Kath RK, Gupta RK. Antioxidant activity of hydroalcoholic leaf extract of Ocimum sanctum in animal models of peptic ulcer. Indian J Physiol Pharmacol 2006;50:391-6.

Jyoti S, Satendra S, Sushma S, Anjana T, Shashi S. Antistressor activity of Ocimum sanctum (Tulsi) against experimentally induced oxidative stress in rabbits. Methods Find Exp Clin Pharmacol 2007;29:411-6.

Mahmood Samim, Sree Hari Yajamanam, Naziya Bano, Veeresh B, Madhav Reddy B. Neuroprotective effect of Ocimum sanctum Linn on rotenone induced Parkinsonism in rats. Int J Pharm Res Scholars 2014;3(1):772-84.

Venuprasad MP, Kumar Kandikattu Hemanth, Khanum Farhath. Neuroprotective effects of hydroalcoholic extract of Ocimum sanctum against H2O2 induced neuronal cell damage in SH-SY5Y cells via its antioxidative defence mechanism. Neurochem Res 2013;38:2190–200.

Jena Jitendra, Gupta Ashish Kumar. Ricinus communis linn: a phytopharmacological review. Int J Pharm Pharm Sci 2012;4(4):25-9.

Gupta Mahesh Kumar, Sharma PK, Ansari SH. In-vitro antioxidant activity of the successive extracts of Ricinus communis leaves. Int J Plant Sci 2006;1(2):229-31.

Sandhya kumary K, Bobby RG, Indira M. Antifertility effects of Ricinus communis Linn on rats. Phytother Res 2003;17:508-11.

Visen PKS, Shukla B, Patnaik GK, Tripathi SC, Kulshreshtha DK, Srimal RC, et al. Hepatoprotective activity of Ricinus communis leaves. In Pharm Biol 1992;30(4):241-50.

Saini Anil Kumar, Goyal Rohit, Gauttam Vinod Kumar, Kalia Ajudhia Nath. Evaluation of anti-inflammatory potential of Ricinus communis Linn leaves extracts and its flavonoids content in Wistar rats. J Chem Pharm Res 2010;2(5):690-5.

Mathur Abhishek, Verma Satish K, Yousuf Sajad, Singh Santosh K, Prasad GBKS, Dua VK. Antimicrobial potential of roots of Riccinus communis against pathogenic microorganisms. Int J Pharm Bio Sci 2011;2(1):545-8.

Shokeen P, Anand P, Murali YK, Tandon V. Antidiabetic activity of 50% ethanolic extract of Ricinus communis and its purified fractions. In Food Chem Toxicol 2008;46:3458-66.

Elimam AM, Elmalik KH, Ali FS. Larvicidal, adult emergence inhibition and oviposition deterrent effects of foliage extract from Ricinus communis L. against Anopheles arabiensis and Culex Quinquefasciatus in Sudan. In Trop Biomed 2009;26(2):130-9.

Rachhadiya Rakesh M, Kabra Mahaveer Prasad, Shete Rajkumar V. Evaluation of antiulcer activity of castor oil in rats. Int J Res Ayurveda Pharm 2011;2(4):1349-53.

Ferraz AC, Angelucci ME, Da Costa ML, Batista IR, De Oliveira BH, Da Cunha C. Pharmacological evaluation of Ricinine, a central nervous system stimulant isolated from Ricinus communis. Pharm Biochem Behav 1999;63(3):367-75.

Lee E, Eom JE, Kim HL, Kang DH, Jun KY, Jung DS, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of l-calpain. Eur J Pharm Sci 2012;46:17–25.

Jain Paras, Sharma HP. A potential ethnomedicinal plant: Semecarpus Anacardium linn-a review. IJRPC 2013;3(3):564-72.

Semalty Mona, Semalty Ajay, Badola Ashutosh, Joshi Geeta Pant, Rawat MSM. Semecarpus anacardium Linn: a review. Pharmacogn Rev 2010;4(7):88-94.

Bhitre MJ, Patil S, Kataria M, Anwikar S, Kadri H. Anti-inflammatory activity of the fruits of Semecarpus anacardium Linn. Asian J Chem 2008;20:2047-50.

Singh D, Aggarwal A, Mathias A, Naik S. Immunomodulatory activity of Semecarpus anacardium extract in mononuclear cells of normal individuals and rheumatoid arthritis patients. J Ethnopharmacol 2006;108:398-06.

Sharma A, Mathur R, Dixit VP. Hypocholesterolemic activity of nut shell extract of Semecarpus anacardium (Bhilawa) in cholesterol fed rabbits. Indian J Exp Biol 1995;33:444-8.

Sahoo AK, Narayanana N, Sahanaa S, Rajanb SS, Mukherjee PK. In vitro antioxidant potential of Semecarpus Anacardium L. Pharmacologyonline 2008;3:327-35.

Mohanta TK, Patra JK, Rath SK, Pal DK, Thatoi HN. Evaluation of antimicrobial activity and phytochemical screening of oils and nuts of Semecarpus anacardium. Sci Res Essay 2007;2:486-90.

Sharma A, Verma PK, Dixit VP. Effect of Semecarpus anacardium fruits on reproductive function of male albino rats. Asian J Androl 2003;5:121-4.

Semalty M, Semalty A, Joshi GP, Rawat MS. Herbal hair growth promotion strategies for alopecia. Indian Drugs 2008;45:689-700.

Shukla Sunil Dutt, Jain Sushma, Sharma Kanika, Bhatnagar Maheep. Stress induced neuron degeneration and protective effects of Semecarpus anacardium Linn and Withania somnifera Dunn in hippocampus of albino rats: an ultrastructural study. Indian J Exp Biol 2000;38:1007-13.

Farooq SM, Alla TR, Rao N Venkat, Prasad K, Shalam, Nandakumar K, et al. A study on CNS effects of milk extract of nuts of Semecarpus anacardium. linn, (Anacardiaceae). Pharmacologyonline 2007;1:49-63.

Jain Ankit, Choubey Shreya, Singour PK, Rajak H, Pawar RS. Sida cordifolia (Linn)-an overview. J Appl Pharm Sci 2011;01(02):23-31.

Mallikarjuna G, Prabhakaran V, Sree Lakshmi K. Pharmacological activities of Sida cordifolia: a review. Int J Phytopharmacol 2013;4(5):315-21.

Ghosal S, Chauhan RRPS, Mehta R. Alkaloids of Sidacordifolia L. Phytherapy Chem 1975;14:830-2.

Auddy B, Ferreira M, Blasina F, Lafon L, Arredondo F, Dajas F, et al. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for management of neurodegenerative diseases. J Ethno pharmacol 2003;84:131-8.

Franzotti EM, Santos CV, Rodrigues HM, Mourao RH, Andrade MR, Antoniolli AR. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia l (malva-branca). J Ethno Pharmacol 2000;72(1-2):273-8.

Kumar RS, Mishra SH. Anti-inflammatory and hepatoprotective activities of Sida cordifolia Linn. Ind J Pharmacol 1997;110-6.

Kotoky J, Das PN. Hepatoprotective activities of Sida cordifolia L roots against carbon tetrachloride intoxicated rats. J Med Arom PI Sci 2001;23:104-7.

Bhatia L, Bhatia V, Grover M. Nephroprotective effect of fresh leaves extract of Sida cordifolia L in gentamycin induced nephrotoxicity in rats. Int J Res Pharm Sci 2012;2(2):151-8.

Kaur Gagandeep, Kamboj Pradeep, Kalia AN. Antidiabetic and anti-hypercholesterolemic effects of aerial parts of Sida cordifolia L on Streptozotocin induced diabetic rats. Indian J Nat Prod Resour 2011;2(4):428-34.

Kalaiarasan S, Ahmed John. Phytochemical screening and antibacterial activity of Sida cordifolia L (Malvaceae) leaf extract. Int J Medicobiol Res 2011;1(2):94-8.

Franco CIF, Morais LCSL, Quintans-Junior LJ, Almeida RN, Antoniolli AR. CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L leaves. J Ethano 2005;98:275-9.

Khurana Navneet, Jain Pushpendra Kumar, Pounikar Yogesh, Patil Shailendra, Gajbhiye Asmita. Reversal of reserpine-induced orofacial dyskinesia and catalepsy by Sida cordifolia. Int J Pharmacol Pharm Technol (IJPPT) 2012;1(2):29-34.

Reddy DB, Reddy TC, Jyotsna G, Sharan S, Priya N, Lakshmipathi V, et al. Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, induces apoptosis in COLO-205 cell line. J Ethnopharmacol 2009;124:506-12.

Surya Prakash DV, Sree Satya N, Sumanjali Avanigadda, Meena Vangalapati. Pharmacological Review on Terminalia Chebula. Int J Res Pharm Biomed Sci 2012;3(2):679-83.

Cheng HY, Lin TC, Yu KH, Yang CM, Lin CC. Antioxidant and free radical scavenging activities of Terminalia chebula. Biol Pharm Bull 2003;26:1331-5.

Saleem A, Husheem M, Harkonen P, Pihlaja K. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz fruit. J Ethnopharmacol 2002;81:327-36.

Rao NK, Nammi S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz seeds in streptozotocin-induced diabetic rats. BMC Complement Altern Me 2006;6(17):1-6.

Kaur S, Grover IS, Singh M. Antimutagenicity of hydrolyzable tannins from Terminalia chebula in Salmonella typhimurium. Mutat Res 1998;419:169-79.

Kannan P, Ramadevi SR, Hopper W. Antibacterial activity of Terminalia chebula fruit extract. Afr J Microbiol Res 2009;3:180-4.

Suchalatha S, Shyamala Devi CS. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Indian J Exp Biol 2004;42:174-8.

Das ND, Jung KH, Park JH, Mondol MA, Shin HJ, Lee HS, et al. Terminalia chebula extract acts as a potential NF-κB inhibitor in human lymphoblastic T cells. Phytother Res 2011;25:927-34.

Chandrashekar R, Manohar VR, Rao SN. Acute anxiolytic effect of aqueous extract of fruits of Terminalia chebula (AETC) in mice. Int J Pharm Bio Sci 2012;3(4):673-7.

Nageswara Rao S, Palaksha MN, Satish S, Ravishankar. The effects of ethanolic extract in dried Ffruits of Terminalia chebula on learning and memory in mice. Asian J Biomed Pharm Sci 2013;3(20):59-62.

Bhakta Prasad Gaire, Nirmala Jamarkattel Pandit, Donghun Lee, Jungbin Song, Ji Young Kim, Juyeon Park, et al. Terminalia chebula extract protects OGD-R induced PC12 cell death and inhibits LPS induced microglia activation. Mol 2013;18:3529-42.

Wesley JJ, Christina AJ, Chidambaranathan N. Effect of alcoholic extract of Tinospora Cordifolia on acute and subacute Inflammation. Pharmacologyonline 2008;3:683-7.

Prince Stanely Mainzen P, Menon VP. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother Res 2003;17:410-3.

Gulati OD, Pandey DC. Anti-inflammatory activity of Tinospora cordifolia. Rheum 1982;17:76-83.

Gulati OD. Clinical trial of Tinospora cordifolia in Rheumatoid Arthritis. Rheum 1980;15:143-8.

Prince Stanely Mainzen P, Menon VP. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytother Res 2001;15:213-8.

Patil M, Patki P, Kamath HV, Patwardhan B. Anti-stress activity of Tinospora cordifolia (Wild) Miers. Indian Drugs 1997;34:211-5.

Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S. Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol 2012;141:918-26.

Jagetia GC, Rao SK. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in ehrlich ascites carcinoma bearing mice. Biol Pharm Bull 2006;29:460-6.

Rawal Avinash K, Muddeshwar Manohar G, Biswas Saibal K. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. BMC Complementary Altern Med 2004;4(11):1-9.

Antony A Shanish, Chinni Santhivardhan, Kannan Elango, Kosaraju Jayasankar, Kumar MN Satish, Roy Partha Deb. Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism. Indian J Pharmacol 2014;46(2):176-80.

Singh SS, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC. Chemistry and medicinal properties of Tinospora Cordifolia (Guduchi). Indian J Pharmacol 2003;35:83-91.

Bairy KL, Rao Y, Kumar KB. Efficacy of Tinospora cordifolia on learning and memory in healthy volunteers: a double blind, randomized, placebo controlled study. Iranian J Pharmacol Therap 2004;3:57-60.

Agarwal A, Malini S, Bairy KL, Rao MS. Effect of Tinospora Cordifolia on learning and memory in normal and memory deficit rats. Indian J Pharmacol 2002;34:339-49.

Chatterjee A, Prakash S. The Treatise on Indian Medicinal Plants. vol. 4. NISCAIR, New Delhi, India; 1995.

Ghani A, Haq SS, Masoodi FA, Broadway AA, Gani A. Physico-chemical, Morphological and pasting properties of starches extracted from water chestnuts (Trapa natans) from three lakes of Kashmir, India. Brazilian Arch Biol Technol 2010;53(3):731-40.

Agrahari AK, Khaliquzzama M, Panda SK. Evaluation of analgesic activity of methanolic extract of Trapa natans l. var. Bispinosa roxb. Roots. J Curr Pharm Res 2010;1:8-11.

Patel Samir, Banji David, Banji Otilia JF, Patel MM, Shah KK. Scrutinizing the role of aqueous extract of Trapa bispinosa as an immunomodulator in experimental animals. Int J Res Pharm Sci 2010;1(1):13-9.

Vyawahare NS, Ambikar DB. Evaluation of neuropharmacological activity of hydroalcoholic extract of fruits of Trapa bispinosa in laboratory animals. Int J Pharm Pharm Sci 2010;2(2):32-5.

Song MC, Yang HJ, Bang MH, Kim DK, Jeong TS, Kim JP, et al. Antioxidant and antiatherogenic activity of cis-Hinokiresinol from Trapa pseudoincisa. Arch Pharm 2007;30:1392-7.

Mei J, Yuan Y, Guo Q, Wu Y, Li Y, Yu H. Characterization and antimicrobial properties of water chestnut starch-chitosan edible films. Int J Biol Macromol 2013;61:169-74.

Razvy MA, Mohammad OF, Hoque A Mohammad. Environment friendly antibacterial activity of water chestnut fruits. J Biodiversity Environ Sci 2011;1(1):26-34.

Kar D, Maharana L, Si SC, Kar MK, Sasmal D. Antiulcer activity of ethanolic extract of fruit of Trapa bispinosa Roxb in animals. Der Pharm Lett 2010;2(2):190-7.

Kar D, Snigdha P, Maharana L, Dash G. Hepatoprotective activity of water chestnut fruit. Indian J Nat Prod 2004;20:17-21.

Adkar Prafulla, Dongare Amita, Ambavade Shirishkumar, Bhaskar VH. Trapa bispinosa Roxb: A review on nutritional and pharmacological aspects. Adv Pharmacol Sci 2014;2014:1-13.

Bhatiwal S, Jain A, Chaudhary J. Trapa natans (Water Chestnut): an overview. Int Res J Pharm 2012;3(6):31-3.

Patel S, Banji D, Banji OJF, Patel MM, Shah KK. Scrutinizing the role of aqueous extract of Trapa bispinosa as an immunomodulator in experimental animals. Int J Res Pharm Sci 2010;1(1):13-9.

Ambikar DB, Harle UN, Khandare RA, Bore VV, Vyawahare NS. Neuroprotective effect of hydroalcoholic extract of dried fruits of Trapa bispinosa Roxb on lipofuscinogenesis and fluorescence product in brain of D-galactose induced ageing accelerated mice. Indian J Exp Biol 2010;48:378-82.

Elsakka M, Grigorescu E, Stanescu U. New data referring to chemistry of Withania somnifera species. Rev Med Chir Soc Med Nat Iasi 1990;94:385-7.

Uddin Qamar, Samiulla L, Singh VK, Jamil SS. Phytochemical and pharmacological profile of Withania somnifera Dunal: a review. J Appl Pharm Sci 2012;02(01):170-5.

Dhuley JN. Effect of Ashwagandha on lipid peroxidation in stress-induced animals. J Ethnopharmacol 1998;60:173-8.

Bhattacharya SK, Satyan KS, Chakrabarti A. Effect of Trasina, An Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. Indian J Exp Biol 1997;35:297-9.

Mir Bilal Ahmad, Kharir Jabeena, Mir Nisar A, Hasan Tanvir-ul, koul Sushma. Botanical, chemical & pharmacological review of Withania somnifera (Indian ginseng): an Ayurvedic medicinal plant. Indian J Drugs Dis 2012;1(6):147-60.

Schliebs R, Liebmann A, Bhattacharya SK, Kumar A, Ghosal S, Bigl V. Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain. Neurochem Int 1997;30:181-90.

Singh Narendra, Pandey BR, Verma Pankaj. An overview of phytotherapeutic approach in p evention and treatment of Alzheimer’s Syndrome & Dementia. Int J Pharm Sci Drug Res 2011;3(3):162-72.




About this article

Title

PROMISING NEUROPROTECTIVE PLANTS FROM NORTH-EAST INDIA

Keywords

Neuroprotection, North-East India, Herbal Medicine, Neurotoxicity, Neuroprotective plant

Date

29-01-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 3, 2015 Page: 28-39

Online ISSN

0975-1491

Statistics

2005 Views | 226 Downloads

Authors & Affiliations

Pankaj Phukan
Assam University, Silchar
India

Meenakshi Bawari
Department of Biotechnology
India

Mahuya Sengupta
Department of Biotechnology
India


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