FORMULATION OF LEVOFLOXACIN AS ORODISPERSIBLE TABLETS USING A READY-MADE BLEND OF EXCIPIENTS COMPARED WITH CLASSIC FORMULATION STRATEGIES

  • Israa H. Al-ani Faculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, 19328 Jordan

Abstract

Objective: Orodispersible tablets are designed to undergo rapid dispersal when they are placed in the mouth prior to being swallowed. The aim of this study was to compare the performance of a ready-made excipients blend designed for orodispersible tablets with several other conventional methods for the manufacture of tablets using levofloxacin as the active pharmaceutical ingredient.

Methods: Several different formulas were prepared to compare the powder characteristics, and the resulting powders were compressed into tablets using the direct compression method. The result compressed tablets was then evaluated in terms of their physical characteristics and drug release properties.

Results: The results of these experiments showed that the use of ready-made blend provided several advantages over the conventional methods in terms of physical properties of the powders and tablets, as well as their drug release and dissolution properties.

Conclusion: The use of a ready-made powder blend in formulation of ODT of model drug levofloxacin had an advantage over the classic methods of formulation.

 

Keywords: Orodispersible tablets, Levofloxacin, Prosolv ODT

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References

1. Bandari S, Mittapalli R, Gannu R, Rao Y. Orodispersible tablets: an overview. Asian J Pharm 2008;2:2-12.
2. Ashish P, Mishra P, Main P. A review on-recent advancement in the development of rapid disintegrating tablet. Int J Life Sci Pharm Res 2011;1:7-16.
3. Dobetti L. Fast-melting tablets: developments and technologies. Pharm Technol Eur 2000;12:32–42.
4. Ghosh T, Ghosh A, Prasad D. A review on new generation orodispersible tablets and its future prospective. Int J Pharm Pharm Sci 2011;3:1-7.
5. Marais AF, Song M, De Villiers MM. Effect of compression force, humidity and disintegrant concentration on the disintegration and dissolution of directly compressed furosemide tablets using croscarmellose sodium as disintegrant. Trop J Pharm Res 2003;2:125-35.
6. Chowdary KPR, Rao N. Formulation and evaluation of nifedepine tablets employing nifedepine: pregelatinized starch dispersions. Indian Drugs 2000;37:122-5.
7. Chowdary KPR, Hymavathy R. Formulation and dissolution rates studies on dispersible tablets of Ibuprofen. Indian J Pharm Sci 2000;63:213-6.
8. Ishikawa T, Mukai B, Shiraishi S. Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M series) and low substituted-hydroxypropylcellulose or spherical sugar. Chem Pharm Bull 2001;59:959–64.
9. Fukami J, Ozawa A, Yoshihashi Y, Yonemochi E, Terada K. Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator: evaluation of wetting and disintegration of tablet on the basis of surface free energy. Chem Pharm Bull 2005;53:1536–9.
10. Rama Rao N, Chowdary KPR. Improvement of dissolution rates bioavailability of Piroxicam with pre-gelatinized starch. Indian J Pharm Sci 2001;63:36-40.
11. Rizk S, Barthelemy C, Duru C. Investigation on a new modified USP Xanthan with tablets disintegration properties. Drug Dev Ind Pharm 1997;23:19-26.
12. Indian Pharmacopoeia, Fourth edition. Vol-II. Controller of publication, Govt. of India, New Delhi; 1996. p. 736.
13. Mishra DN. Rapidly disintegrating oral tablets of meloxicam by direct compression method. Indian Drugs 2006;43:117-21.
14. Shinde G, Rathinaraj B. New generation of orodispersible tablets: recent advances and and future prospects. Int J Adv Pharm Sci 2011;2:17-28.
15. Deshmukh VN. Mouth dissolving drug delivery systems: a review. Int J Pharm Tech Res 2012;4:412-21.
16. Goudanaver P, Shah S, Hiremath D. Development and characterization of lamotrigine orodispersible tablets: inclusion complex with hydroxypropyle B cyclodextrin. Int J Pharm Pharm Sci 2012;3:1-7.
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How to Cite
Al-ani, I. H. “FORMULATION OF LEVOFLOXACIN AS ORODISPERSIBLE TABLETS USING A READY-MADE BLEND OF EXCIPIENTS COMPARED WITH CLASSIC FORMULATION STRATEGIES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, no. 11, Aug. 2015, pp. 252-5, https://innovareacademics.in/journals/index.php/ijpps/article/view/4845.
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