A STUDY OF VANCOMYCIN RESISTANT ENTEROCOCCI ISOLATED FROM URINARY TRACT INFECTIONS
Keywords:
Enterococci, Urinary Tract Infection, Vancomycin ResistanceAbstract
Objective: Vancomycin resistant enterococci (VRE) are becoming a major emergence problem concern in urinary tract infection (UTI). This study provides accurate and complete description of antimicrobial susceptibility pattern and to know the prevalence of VRE in this area.
Methods: A total of 3400 urine samples were collected and processed bacteriologically. The enterococci was isolated and identified by biochemical tests and Vitek 2. VRE was determined by disc diffusion, agar dilution and Vitek 2 automated machine. Statistical analysis was done by Graph Pad InStat Software.
Results: The 143 (4.2%) enterococci were isolated from UTI patients. The incidence was higher in young females and old males. E. faecalis (78%) is the most common isolate followed by E. faecium (15%). The rare species (9%) like E. durans, E. avium, E. gallinarum and E. hirae were also isolated. Fosfomycin (96.5%) and nitrofurantoin (93%) was the drug of choice for enterococcal UTI while linezolid (98.6%) also can be used to treat other enterococcal infections. Among the UTI 98.6% enterococci were susceptible to vancomycin.
Conclusion: Empirical therapy for enterococcal infections should be guided by local patterns of drug resistance. Linezolid, fosfomycin or nitrofurantoin may be considered to treat the patients with VRE.
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References
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