• Ateufack Gilbert Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang P. O. box 67 Dschang Cameroon
  • Mikwangock Domegne Hauberline M. Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang P. O. box 67 Dschang Cameroon
  • Dongmo Feudjio Breuil R Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang P. O. box 67 Dschang Cameroon
  • Yousseu Nana William Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang P. O. box 67 Dschang Cameroon
  • Kamanyi Albert Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang P. O. box 67 Dschang Cameroon


Objective: Dissotis thollonii is used in Cameroonian ethnomedicine to cure diseases such as inflammations, pregnancy control, diarrhea and gastric ulcer. The aqueous and methanol leaf extracts were evaluated for their anti ulcerogenic and antiulcer activities.

Methods: The extracts were administered at the doses of 125, 250 and 500 mg/kg to evaluate their effects on gastric ulcer induced by the HCl/ethanol mixture, indomethacin and acetic acid in rats. Ranitidine, Maalox and Misoprostol were used as standard drugs. Histopathological examination and nitric oxide level was performed to evaluate the basic action mechanism of Dissotis thollonii.

Results: Oral administration of the plant dose-dependently prevented HCl/ethanol-induced gastric ulcers (72.15 to 100 % for aqueous extract and 68.78 to 89.60 % for methanol extract), Indomethacin (51.13 to 100 % for aqueous extract and-32.33 to 58.45 % for methanol extract). The extracts also promoted the healing and cicatrization process in chronic gastric ulcer induced by acetic acid and increased the NO level in plasma. Histological studies of the gastric wall revealed that ulcer control group exhibited severe damage of the gastric mucosa, compared to rats pre-treated with extracts, which comparatively showed gastric mucosal protection.

Conclusion: Dissotis thollonii possess protective and healing activities in rats. The anti ulcerogenic activity may be attributed to the stimulation of the prostaglandins synthesis and antiulcer property to increase NO level in plasma. Histological investigation of gastric lesion shows that the plant stimulates the cicatrizing process. These results supported the ethnomedicinal uses of Dissotis thollonii in the treatment of gastric ulcers.


Keywords: Dissotis thollonii, Anti ulcerogenic, Antiulcer


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How to Cite
Gilbert, A., M. D. Hauberline M., D. F. Breuil R, Y. N. William, and K. Albert. “ANTIULCEROGENIC AND ANTIULCER ACTIVITIES OF DISSOTIS THOLLONII (MELASTOMATACEAE) LEAVES IN RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 8, June 2015, pp. 62-69,
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