INVESTIGATION OF NIFEDIPINE SOLID DISPERSION WITH SOLVENT PVP K-30


Endang Diyah Ikasari, Achmad Fudholi, Sudibyo Martono, Marchaban .

Abstract


Objective: The objective of this study was to investigate solid dispersions of nifedipine and polyvinylpyrrolidone K-30 in different drug loads.

Methods: Solid dispersions with drug loads 20%, 30%, 50% were prepared by spray dried method. Drug-carrier interaction was analyzed with FT-IR, X-ray Powder Difractometry (XRPD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and In-vitro drug release.

Results: The results were as follows: (1) solid dispersions was granulated, yellow, and had a free flowing nature. (2) FT-IR spectra had no interaction between nifedipine with PVP K-30, (3) the assay of formulas met all the requirements of 90%-110%, (4) XRPD patterns of all PVP-based solid dispersions with nifedipine incorporated showed no distinctive peaks of crystalline nifedipine, (5) thermograms of these physical mixtures showed broad melting peak of nifedipine and shifted to the lower temperature indicating the partial miscibility of drug in carrier during DSC scan, (6) Scanning electron microscopy study releaved that the solid dispersion were spherical and porous in nature.

Conclusion: Dissolution behavior of solid dispersion based on the PVP K-30 was determined by dissolution of the carrier. A lower drug load will increase drug dissolution of solid dispersions.


Keywords


Spray dried method, Nifedipine, Amorphous solid dispersions, Dissolution, Polyvinylpyrrolidone K-30

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References


Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000;50:47–60.

Craig DQM. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm 2002;231:131–44.

Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J Pharm Sci 1971;60:1281–302.

Philo LMS, Shah S, Badarinath AV, Gopinath C. Formulation and evaluation of octreotide acetate loaded PLGA microspheres. Int J Pharm Pharm Sci 2013;5(3):625-21.

Srinarong P, Sander K, Marinella RV, Wouter LJH, Henderik WF. Effect of drug-carrier interaction on the dissolution behavior of solid dispersion tablets. Pharm Dev Technol 2009;14:1-9.

Forster A, Hempenstall J, Rades T. Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers. J Pharm Pharmacol 2001;53:303–15.

Matteucci ME, Brettmann BK, Rogers TL, Elder EJ, Williams RO, Johnston KP. Design of potent amorphous drug nanoparticles for rapid generation of highly supersaturated media. Mol Pharm 2007;4(5):782-93.

Vasanthavada M, Tong W-Q, Joshi Y, Kislalioglu MS. Phase behavior of amorphous molecular dispersions II: Role of hydrogen bonding in solid solubility and phase separation kinetics. Pharm Res 2005;22:440–8.

Friedrich H, Nada A, Bodmeier R. Solid state and dissolution rate characterization of co-ground mixtures of nifedipine and hydrophilic carriers. Drug Dev Ind Pharm 2005;31:719–28.

Kumar, Kiran M, Chinna E, VNL Sirisha. Solubility enhancement techniques of drug. Int Res J Pharm Appl Sci 2012;2(5):49-55.

Patil RM, Ajim HM, Mangesh TK, Anup MA, Dheeraj TB. Solid dispersion: strategy to enhance solubility. Int J Pharm Sci Rev Res 2011;8(2):71.

Cai T, Zhu L, Yu L. Crystallization of organic glasses: effects of polymer additives on bulk and surface crystal growth in amorphous nifedipine. Pharm Res 2011;28(10):2458-66.

Marsac PJ, Konno H, Taylor LS. A Comparison of the physical stability of amorphous felodipine and nifedipine system. Pharm Res 2006;23(10):2306-16.

Marsac PJ, Konno H, Rumondor ACF, Taylor LS. Recrystallization of nifedipine and felodipine from amorphous molecular level solid dispersions containing Poly (vinylpyrrolidone) and Sorbed Water. Pharm Res 2008;25(3):647-56.

Moffat AC, Osselton MD, Widdop B. Clarke’s analysis of drugs and poisons: Fourth Edition. Pharmaceutical Press, London; 2011.

Friedrich H, Nada A, Bodmeier R. Solid state and dissolution rate characterization of co-ground mixtures of nifedipine and hydrophilic carriers. Drug Dev Ind Pharm 2005;31:719–28.




About this article

Title

INVESTIGATION OF NIFEDIPINE SOLID DISPERSION WITH SOLVENT PVP K-30

Keywords

Spray dried method, Nifedipine, Amorphous solid dispersions, Dissolution, Polyvinylpyrrolidone K-30

Date

01-04-2015

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 7, Issue 4, 2015 Page: 389-392

Online ISSN

0975-1491

Authors & Affiliations

Endang Diyah Ikasari
Yayasan Pharmasi College of Pharmacy, Semarang 50193, Indonesia

Achmad Fudholi
Gadjah Mada University
Indonesia

Sudibyo Martono
Gadjah Mada University
Indonesia

Marchaban .
Gadjah Mada University
Indonesia


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