SESBANIA GRANDIFLORA: NEW NUTRACEUTICAL USE AS ANTIDIABETIC
Nutraceuticals are the emerging era in the treatment of diabetes mellitus, one of the seriously problematic due to leading the causes of death in all over the world. The newer anti-hyperglycemic drugs continue searching because the existing synthetic drugs have several limitations. Traditional medicinal plants are used in the treatment of diabetes mellitus more than a century, but only a few of these have proofed their safe and efficacious. The aim of this review article is focused Sesbania grandiflora one of the medicinal plants used for antioxidant activities. It contains several kinds of alkaloids, flavonoids, saponins, tannin, diterpenes, triterpenoids, glycosides and phenols. Many researchers have evaluated that these phytochemical substances have the major impact on diabetes mellitus. This review focuses on the hypoglycemic activity of this plant and clears that it has the potential to be considered as a candidate for preparing the new treatment of diabetes mellitus.
2. Majaz Q, Molvi Khurshid I, Nazim S, Asir Q, Shoeb Q. Nutraceuticals: Importance and advances in medicine and health. Int Res J Pharm 2012;3:71-3.
3. Chintale Ashwini G, Kadam Vaishali S, Sakhare Ram S, Birajdar Ganesh O, Nalwad Digambar N. Role of nutraceuticals in various diseases: A comprehensive review. Int J Res Pharm Chem 2013;3:290-9.
4. Brower V. A nutraceutical a day may keep the doctor away. EMBO Reports 2005;8:708-11.
5. Wargovich MJ, Morris J, Brown V, Ellis J, Logothetis B, Weber R. Nutraceutical use in late-stage cancer. Cancer Met Rev 2010;29:503-10.
6. Kuppusamy P, Yusoff MM, Maniam GP, Ichwan SJA, Soundharrajan I, Govindan N. Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharm Sinica B 2014;4:173-81.
7. Ahmad A, Ginnebaugh KR, Li Y, Padhye SB, Sarkar FH. Molecular targets of naturopathy in cancer research bridge to modern medicine. Nutrients 2015;7:321-34.
8. Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules 2010;15:7792-814.
9. Riqacci S, Stefani M. Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols. Expert Rev Neurother 2015;15:41-52.
10. Rama CS, Shirode AR, Mundada AS, Kadam VJ. Nutraceuticals-an emerging era in the treatment and prevention of cardiovascular diseases. Curr Pharm Biotechnol 2006;7:15-23.
11. Zuchi C, Amgrosio G, Luscher TF, Landmesser U. Nutraceuticlas in cardiovascular prevention: Lessons from studies on endothelial function. Cardiovasc Ther 2010;8:187-201.
12. Pandey M, Vijayakumar. Nutraceutical supplementation for diabetes: A review. Int J Pharm Pharm Sci 2011;3:33-40.
13. Daftardar S, Kaur G, Addepalli V. Nutraceutical approaches in the management of cardiovascular dysfunctions associated with diabetes mellitus. In: Turan B, Dhalla NS, editors. Diabetic Cardiomyopathy Advances in Biochemistry in Health and Disease. New York: Springer-Verlag; 2014. p. 377-96.
14. Kaur G, Mukundan S, Wani V, Kumar MS. Nutraceuticals in the management and prevention of metabolic syndrome. Austin J Pharm Ther 2015;3:1063.
15. World Health Organization. Global health estimates: Deaths by Cause, Age, Sex and Country, 2000-2012. World Health Organization: Geneva; 2014.
16. Moses RG. Combination therapy for patients with type 2 diabetes: Repaglinide in combination with metformin. Expert Rev Endocrinol Metab 2010;5:331-42.
17. Abo KA, Fred-Jaiyesimi AA, Jaiyesimi AEA. Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria. J Ethnopharmacol 2008;115:67-71.
18. Mustafa AA, Fawibe OO, Ajiboye AA, Agboola DA. Ethnobotanical survey of medicinal plants used in the treatment of diabetes in Irepodun local government area of Osun State, Nigeria. Greener J Biol Sci 2014;4:59-68.
19. Erasto P, Adebola PO, Grierson DS, Afolayan AJ. An ethnobotanical study of plants used for the treatment of diabetes in the Eastern Cape Province, South Africa. Afr J Biotechnol 2005;4:1458-60.
20. Semenya S, Potgieter M, Erasmus L. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa. J Ethnopharmacol 2012;141:440-5.
21. Kadir MF, Sayeed MSB, Shams T, Mia MMK. Ethnobotanical survey of medicinal plants used by Bangladeshi traditional health practitioners in the management of diabetes mellitus. J Ethnopharmacol 2012;144:605â€“11.
22. Ocvirk S, Kistler M, Khan S, Talukder SH, Hauner H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh-An ethnobotanical survey. J Ethnobiol Ethnomed 2013;9:43.
23. Tarafdar RG, Nath S, Talukdar AD, Choudhury MD. Antidiabetic plants used among the ethnic communities of Unakoti district of Tripura, India. J Ethnopharmacol 2015;160:219-26.
24. Durmuskahya C, Ozturk M. Ethnobotanical survey of medicinal plants used for the treatment of diabetes in Manisa, Turkey. Sains Malaysiana 2013;45:1431-8.
25. Bahmani M, Zargaran A, Rafieian-Kopaei M, Saki K. Ethnobotanical study of medicinal plants used in the management of diabetes mellitus in the Urmia, Northwest Iran. Asian Pac J Trop Med 2014;7S1:S348-54.
26. Manosroia J, Mosesb ZZ, Manosroid W, Manosroia A. Hypoglycemic activity of Thai medicinal plants selected from the Thai/lanna medicinal recipe database MANOSROI II. J Ethnopharmacol 2011;138:92-8.
27. Padal SB, Sandhya Sri B, Raju JB. Ethno-medicine used against fever among the tribes of Visakhapatnam district, Andhra Pradesh, India. Int J Ethnobiol Ethnomed 2014;1:1-5.
28. Kashyap S, Mishra S. Phytopharmacology of Indian plant Sesbania grandiflora L. J Phytopharmacol 2012;1:63-75.
29. Orwa C, Mutua A, Kindt R, Jamnadass R, Simons A. Sesbania grandiflora. Agroforestree Database: a tree reference and selection guide; 2009.
30. Bhoumik D, Dwivedi J. A review on pharmacological activity of Sesbania grandiflora Linn. Columbia J Pharm Sci 2014;1:40-3.
31. Yadav P, Harisha CR, Prajapati PK. Pharmacognostical and physicochemical evaluation of Agasti leaf. Int J Ayurveda Res 2010;1:231-6.
32. Lakshmi T. Hadga (Sesbania grandiflora Linn.)-A unique Ayurvedic remedy. Int J Drug Dev Res 2011;3:1-3.
33. Venkataeshwarhu G, Shantha TR, Shiddamallayya N, Kishore KR. Traditional and Ayurvedic medicinal importance of agasthya leaves [Sesbania grandiflora (L) Pers.] WRT its pharmacognostic and physicochemical evaluation. Int J Res Ayurveda Pharm 2012;3:193-7.
34. Reeta M, Ravindra S, Akhilesh M, Rama Murthy A. Agastya (Sesbania grandiflora Linn.): Ayurvedic approach. Uni J Pharm 2013;2:1-5.
35. Dwivedi C, Chandrakar K, Singh V, Tiwari SP, Satapathy T, Kesharwani S, et al. Indian herbal medicines used for treatment of dementia: An overview. Int J Pharm 2014;1:553-71.
36. Gopalan C, Ramasastri BV, Balasubramanian SC. Nutritive value of indian foods national institute of nutrition (Indian council of Medical Research) Hyderabad, India; 2007. p. 18-48.
37. Al-Dawah NKJ, Al-Safi SMM, Aboktifa MA, Al-Zeiny SSM, Al-Shimmary BAA, Al-Bayati MTN, et al. Comparative of phytochemical and antimicrobial of Sesbania grandiflora leaves extract. Med J Babylon 2014;11:3.
38. Avalaskar AN, Itankar PR, Joshi VS, Agrawal M, Vyas J. Phytochemical and TLC studies of ethanolic extract of Sesbania grandiflora (Fabaceae). Int J Pharm Tech Res 2011;3:1346-9.
39. Arun A, Karthikeyan P, Sagadevan P, Umamaheswari R, Rex Peo R. Phytochemical screening of Sesbania grandiflora (Linn). Int J Biosci Nanosci 2014;1:33-6.
40. Hasan N, Osman H, Mohamad S, Chong WK, Awang K, Zahariluddin ASM. The chemical components of Sesbania grandiflora root and their antituberculosis activity. Pharmaceuticals 2012;5:882-9.
41. Arunabha M, Satish N. Study the immunomodulatory effects of combined extracts of Sesbania grandiflora flowers and Cocculus hirsutus leaves on the circulating antibody response. Am J Phytomed Clin Ther 2015;3:199-208.
42. Patil RB, Nanjwade BK, Manvi FV. Effect of Sesbania grandiflora and Sesbania sesban bark on Carragennan induce acute inflammation and adjuvant induced arthritis in rats. Int J Pharm Sci 2010;1:75-89.
43. Jothi Karumari R, Sumathi S, Vijayalakshmi K, Ezhilarasi Balasubramanian S. Anthelmintic efficacy of Sesbania grandiflora leaves and Solanum torvum fruits against the nematode parasite Ascaridia galli. Am J Ethnomed 2014;1;326-33.
44. Sreelatha S, Padma PR, Umasankari E. Evaluation of anticancer activity of ethanol extract of Sesbania grandiflora (Agati Sesban) against Ehrlich ascites carcinoma in Swiss albino mice. J Ethnopharmacol 2011;134:984-7.
45. Ghanshyam P, Chhayakanta P, Shankar MU, Sujata M, Gourishyam P, Kuman AA. Investigation of possible hypoglycemic and hypolipidemic effect of methanolic extract of Sesbania grandiflora. Int Res J Pharm 2012;3:275-80.
47. Nandi MK, Garabadu D, Krishnamurthy S, Singh TD, Singh VP. Methanolic fruit extract of Sesbania grandiflora exhibits anti-hyperglycemic activity in experimental type-2 diabetes mellitus model. Ann Biol Res 2014;5:50-8.
48. Radhika J, Christia R, Jothi G. Effect of the aqueous extract of Sesbania grandiflora Linn in alloxan induced diabetes in albino rats. World J Pharm Res 2014;3:677-85.
49. Doddola S, Pasupulati H, Koganti B, Prasad KV. Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. J Nat Med 2008;62:300-7.
50. Shyamala Gowri S, Vasabtha K. Free radical scavenging and antioxidant activity of leaves from agathi (Sesbania grandiflora) (L.) Pers. Am-Eur J Sci Res 2010;5:114-9.
51. Bhalke RD, Giri MA, Anarthe SJ, Pal SC. Antiulcer activity of the ethanol extract of leaves of Sesbania grandiflora (Linn.). Int J Pharm Pharm Sci 2010;2:206-8.
52. Roy A, Bhoumik D, Sahu RK, Dwivedi J. Anti-ulcer activity of aqueous extract of Sesbania grandiflora Linn stems in experimental animals. Indian J Res Pharm Biotechnol 2014;2:1254-6.
53. Pari L, Uma A. Protective effect of Sesbania grandiflora against erythromycin estolateinduces hepatotoxicity. Therapie 2003;58:439â€“43.
54. Tathe PR, Bheemachari, Uplanchiwar V, Modi A, Gahane A, Jain SK, et al. Hepatoprotective activity of fruit extract of Sesbania grandiflora, Pers. Pharmacologyonline 2010;3:423-30.
55. Ramesh T, Begum VH. Effect of Sesbania grandiflora on lung antioxidant defense system in cigarette smoke exposed rats. Int J Biol Chem 2007;1:141â€“8.
56. Kumaravel M, Karthiga K, Raviteja V, Rukkumani R. Protective effects of Sesbania grandiflora on kidney during alcohol and polyunsaturated fatty acid-induced oxidative stress. Toxicol Mech Methods 2011;21:418-25.
57. National Academy of Sciences, NAS. Tropical Legumes: Resources for the Future. National Academy Press: Washington DC; 1979. p. 331.
58. Hutagalung RI. The use of tree crops and their by-products for intensive animal production. In: Smith AJ, Gunn RG. editors. Intensive animal production in developing countries occasional publication No.4, British Society of Animal Production; 1981. p. 151-84.
59. Gurib-Fakim A. Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol Aspects Med 2006;27:1-93.
60. Sangeetha A, Sriram Prasath G, Subramanian S. Antihyperglycemic and antioxidant potentials of Sesbania grandiflora leaves studies in STZ induced experimental diabetic rats. Int J Pharm Sci Res 2014;5:2266-75.
61. Boonmee A, Reynolds CD, Sangvanich P. Alpha-glucosidase inhibitor proteins from Sesbania grandiflora flowers. Planta Med 2007;73:1197â€“201.
62. Prasanna G, Saraswathi NT. The therapeutic role of Sesbania grandiflora as an inhibitor of advanced glycation endproduct (AGE) formation and the discovery of lead compounds for managing hyperglycaemia. Planta Med 2013;79:PN84.
63. Sathish R, Madhavan R, Vasanthi HR, Amuthan A. In-vitro alpha-glucosidase inhibitory activity of abraga chendhooram, a Siddha drug. Int J Pharmacol Clin Sci 2012;1:79-81.
64. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol-Renal Physiol 2006;290:F625-31.
65. Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 2013;62:3307-15.
66. Zarena AS, Gopal S, Vineeth R. Antioxidant, antibacterial, and cytoprotective activity of agathi leaf protein. J Anal Methods Chem 2014. doi.org/10.1155/2014/989543. [Article in Press].
67. Kumaravel M, Karthiga K, Raviteja V, Rukkumani R. Protective effects of Sesbania grandiflora on kidney during alcohol and polyunsaturated fatty acid-induced oxidative stress. Toxicol Mech Methods 2011;21:418-25.
68. Pari L, Uma A. Protective effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. Therapie 2003;58:439-43.
69. Nandi MK, Garabadu D, Krishnamurthy S, Singh TD, Singh VP. Methanolic fruit extract of Sesbania grandiflora exhibits anti-hyperglycemic activity in experimental type-2 diabetes mellitus model. Ann Biol Res 2014;5:50.